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  4. Recombinant Mouse Signal transducer and activator of transcription 4 (Stat4)

Recombinant Mouse Signal transducer and activator of transcription 4 (Stat4)

  • 货号：
    CSB-YP022813MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP022813MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP022813MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP022813MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP022813MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Stat4; Signal transducer and activator of transcription 4
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-749
  • 氨基酸序列
    MSQWNQVQQL EIKFLEQVDQ FYDDNFPMEI RHLLAQWIET QDWEVASNNE TMATILLQNL LIQLDEQLGR VSKEKNLLLI HNLKRIRKVL QGKFHGNPMH VAVVISNCLR EERRILAAAN MPIQGPLEKS LQSSSVSERQ RNVEHKVSAI KNSVQMTEQD TKYLEDLQDE FDYRYKTIQT MDQGDKNSIL VNQEVLTLLQ EMLNSLDFKR KEALSKMTQI VNETDLLMNS MLLEELQDWK KRQQIACIGG PLHNGLDQLQ NCFTLLAESL FQLRQQLEKL QEQSTKMTYE GDPIPAQRAH LLERATFLIY NLFKNSFVVE RQPCMPTHPQ RPMVLKTLIQ FTVKLRLLIK LPELNYQVKV KASIDKNVST LSNRRFVLCG THVKAMSSEE SSNGSLSVEF RHLQPKEMKC STGSKGNEGC HMVTEELHSI TFETQICLYG LTINLETSSL PVVMISNVSQ LPNAWASIIW YNVSTNDSQN LVFFNNPPSV TLGQLLEVMS WQFSSYVGRG LNSEQLNMLA EKLTVQSNYN DGHLTWAKFC KEHLPGKTFT FWTWLEAILD LIKKHILPLW IDGYIMGFVS KEKERLLLKD KMPGTFLLRF SESHLGGITF TWVDQSENGE VRFHSVEPYN KGRLSALAFA DILRDYKVIM AENIPENPLK YLYPDIPKDK AFGKHYSSQP CEVSRPTERG DKGYVPSVFI PISTIRSDST EPQSPSDLLP MSPSAYAVLR ENLSPTTIET AMNSPYSAE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Carries out a dual signal transduction and activation of transcription.
  • 基因功能参考文献：
    1. The results show that STAT4 plays a critical role in mediating both Th1 and Th2 responses upon immunization with monophosphoryl lipid A. PMID: 27578456
    2. this study shows that STAT4 regulates the CD8(+) regulatory T cell/T follicular helper cell axis and promotes atherogenesis in insulin-resistant Ldlr(-/-) mice PMID: 29055004
    3. virus-specific effector and memory CD4 T cells formed independently of Tbet and STAT4, although a slight reduction in the number of antigen-specific CD4 T cells was apparent in mice lacking both transcription factors. PMID: 24231259
    4. expression associated with early Inflammation in diabetic wounds PMID: 28107529
    5. STAT4 has a pro-atherogenic role that is at least partially independent of Th1 cell-derived interferon-gamma PMID: 26386214
    6. Modulation of IL-12/STAT4 signaling may be a valuable therapeutic strategy to preserve islet/beta-cell viability in established diabetes PMID: 26555476
    7. This study found that stathmin plays an important role in adult hippocampal neurogenesis and spinogenesis. In addition, stathmin mutation led to impaired NMDA receptor-dependent and neurogenesis-associated memory PMID: 26818507
    8. STAT4 controls GM-CSF production by both Th1 and Th17 cells during experimental autoimmune encephalomyelitis. PMID: 26123499
    9. Data (including data from studies in knockout mice) suggest Stat4 deletion reduces inflammation in peri-vascular and visceral adipose tissue and this appears to contribute via direct or indirect effects to reduced atheroma formation. PMID: 26285907
    10. T-bet- and STAT4-dependent IL-33 receptor expression have roles in directly promoting antiviral Th1 cell responses PMID: 25829541
    11. Primary infections of mice with lymphocytic choriomeningitis virus (LCMV) demonstrated that T cell receptor stimulation induced responsiveness for IFN-gamma and CD25 induction through STAT4-independent pathways. PMID: 25336459
    12. STAT4 appears to be a critical transcription factor in defense against mycobacterial infection PMID: 12488562
    13. STAT4 deficiency protects against neointima formation following arterial injury in mice. PMID: 24933129
    14. IL-12 drives small airway remodeling via STAT4 signaling. PMID: 24922586
    15. These data demonstrate that STAT4 regulates the respiratory syncytial virus-specific CD8+ T cell response to secondary infection but does not independently regulate lung Th2 or Th17 immune responses. PMID: 24920804
    16. STAT4 is dispensable for antimonial-based chemotherapy. PMID: 24242758
    17. We have identified STAT4 as a key contributor to insulin resistance and AT inflammation in diet-induced obesity. PMID: 23939393
    18. STAT4 deficiency has no conspicuous effect on the development and fecundity of S. japonicum. PMID: 22164377
    19. loss of either STAT4 or T-box expressed in T cells increased Ifng promoter CpG methylation in both effector and memory Th2 cells. PMID: 23761633
    20. one mechanism for STAT4-dependent gene programming is in establishing a derepressed genetic state susceptible to transactivation by additional fate-determining transcription factors. PMID: 23772023
    21. These findings confirm the results of genetics studies on the role of STAT-4 in the development of systemic sclerosis. PMID: 21360510
    22. Mice that lacked STAT4 had impaired HSV-2-specific IFN-gamma production and delayed-type hypersensitivity responses. PMID: 22718836
    23. CWE was able to down-regulate IFN-gamma expression in activated T cells without altering IL-2 production, involving inhibition of p38, JNK, ERK1/2, and STAT4. PMID: 22053946
    24. Our results represent the first evidence that the SDF-1/CXCR4 axis upregualtes myocardial STAT3 activation PMID: 21821779
    25. Results highlight the critical role of Stat4 Th1 signals in autoimmune responses in suppressing Foxp3(+) Treg responses and altering the balance between Th17 and Tregs to favor autoimmune disease. PMID: 21525389
    26. gamma rays cause a decrease in IFN-gamma, IL-12p70, IL-12 receptor beta2, and STAT4 and an increase in IL-4 in natural killer cells PMID: 21219110
    27. Expression of tenascin-C is significantly attenuated in the airways of STAT4-/- mice, which may be due to the impaired secretion of TNF-alpha and IFN-gamma in these mice. PMID: 21205293
    28. Circulating IL-18 levels were elevated in Stat4-deficient compared to Stat4-intact mice, suggesting that this interleukin might contribute to the progression of lupus nephritis independent of Stat4. PMID: 20980973
    29. The present data suggest that IL-13-mediated asthma phenotypes, such as airway-hyperresponsiveness and non-eosinophilic inflammation, in the Th2 type asthma are dependent on the IL-12-STAT4-IFN-gamma axis. PMID: 20592486
    30. STAT4 and STAT6 play wide regulatory roles in T helper cell specification. PMID: 20620946
    31. The absence of (T helper) TH1 and elevation of TH2 responses in STAT4-/- mice had no role in protection against ocular herpes simpex virus type 1 infection but did have an effect on immunoglobulin-G (IgG)-subtype switching and early viral replication. PMID: 20104254
    32. role in IL-12 induction of T cell CCR5 PMID: 11739505
    33. STAT4 up-regulates AP-1-mediated IFN-gamma promoter activation without directly binding to the promoter sequence, providing a mechanistic explanation for IL-12/IL-18-induced synergistic enhancement of IFN-gamma gene expression. PMID: 11801649
    34. IFN-alphabeta alone induces tyrosine phosphorylation of STAT4 in murine splenocytes of different mouse strains. PMID: 12165484
    35. phosphorylation of STAT4 on both tyrosine and serine residues is important in promoting normal T(H)1 differentiation and IFN-gamma secretion PMID: 12213961
    36. demonstrated that IFN-alpha activates STAT4 directly and that this is required for IFN-gamma production during viral infections of mice, in concert with T cell receptor-derived signals PMID: 12242445
    37. Activated STAT4 plays an essential downstream role in the early events of IL-12-induced Th1 cell differentiation that is independent of its role in the support of IL-12R beta 2 chain signaling. PMID: 12370372
    38. Mucosal Ad-IFN-gamma gene transfer can effectively attenuate established allergen-induced airway inflammation and airway hyperreactivity, predominantly through an IL-12- and STAT4-dependent mechanism. PMID: 12396623
    39. STAT4 was not required for the host response during experimental vesicular stomatitis virus encephalitis. PMID: 12458040
    40. Role of signal transducer and activator of transcription 4 (Stat4) and Stat6 signaling in liver I/R injury. PMID: 12540779
    41. A role is outlined for Stat4 in the development of the local allergic airway response via a mechanism centered on the production of chemokines and enhanced accumulation of appropriate effector cells. PMID: 12646654
    42. GATA-3 expression in developing Th1 cells does not block Th1 development in cells coexpressing Stat4 but does so in cells coexpressing T-bet. PMID: 12648458
    43. Stat4 may play a role in autoantibody production in lupus-prone New Zealand Mixed 2410 mice that develop a severe glomerulosclerosis and rapidly progressive renal disease. PMID: 12707364
    44. mice that were STAT4 deficient are be protected from renal ischemia reperfusion injury PMID: 12709397
    45. Stat4-deficient New Zealand mixed 2328 (NZM) mice develop accelerated nephritis and increased mortality in the absence of high levels of autoantibodies including anti-double-stranded DNA Abs, and in the presence of relatively reduced levels of IFN-gamma. PMID: 12874250
    46. Naturally occurring alternative splicing forms of Stat4 were isolated (Stat4alpha and Stat4beta); each had distinct requirements in IL-12 responses. PMID: 12912921
    47. Stat4 and Stat6 regulate opposing programs of T helper differentiation PMID: 12965077
    48. STAT4 has a role in interleukin-12-induced chromatin remodeling of the CD25 locus PMID: 14660657
    49. Acetylcholine receptor-specific Th1 cells are nearly absent in wild-type and STAT4-deficient BALB/c mice; these animals are resistant to experimental myasthenia gravis. PMID: 14688314
    50. nonphosphorylated STAT4 dimers form in vivo before cytokine receptor-driven activation PMID: 14704793

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.
  • 蛋白家族：
    Transcription factor STAT family
  • 数据库链接：

    KEGG: mmu:20849

    STRING: 10090.ENSMUSP00000027277

    UniGene: Mm.1550