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  4. Recombinant Mouse Signal transducing adapter molecule 2 (Stam2)

Recombinant Mouse Signal transducing adapter molecule 2 (Stam2)

  • 货号：
    CSB-YP022793MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP022793MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP022793MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP022793MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP022793MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Stam2; Hbp; Signal transducing adapter molecule 2; STAM-2; Hrs-binding protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-523
  • 氨基酸序列
    MPLFTANPFE QDVEKATNEY NTTEDWSLIM DICDRVGSTP SGAKDCLKAI MKRVNHKVPH VALQALTLLG ACVANCGKIF HLEVCSRDFA TEVRSVIKNK AHPKVCEKLK SLMVEWSEEF QKDPQFSLIS ATIKSMKEEG VTFPSAGSQT VAAAAKNGTS LNKNKEDEDI AKAIELSLQE QKQQYTETKA LYPPAESQLN NKAARRVRAL YDFEAVEDNE LTFKHGELIT VLDDSDANWW QGENHRGTGL FPSNFVTTDL STEVETATVD KLNVIDDDVE EIKKSEPEPV YIDEGKMDRA LQILQSIDPK ESKPDSQDLL DLEDVCQQMG PMIDEKLEEI DRKHSELSEL NVKVLEALDL YNKLVNEAPV YSVYSKLHPA HYPPAAAGVP VQTYPVQSHG GNYLGHGIHQ VSVAQNYNLG PDPMGSLRSL PPNMNSVTAH TVQPPYLSTG QDTVSNPSYM NQSSRLQAAA GTAAYTQPVG MSTDVSSFQN TASGLPQLAG FPVAVPAPVA AQPQASYHQQ PLL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.
  • 基因功能参考文献：
    1. Stam2 is expressed in the nervous tissue, heart, digestive and endocrine system during embryo development. PMID: 22143071
    2. STAM proteins function in a multivalent complex that sorts ubiquitinated proteins into the multivesicular body pathway. PMID: 12551915
    3. SH3 domains of STAM2 and Grb2 retain the moderate characteristics of recognizing their ligand proteins like other SH3 domains for signal protein binding PMID: 13129930
  • 亚细胞定位：
    Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族：
    STAM family
  • 组织特异性：
    Ubiquitously expressed, with highest levels in testis.
  • 数据库链接：

    KEGG: mmu:56324

    STRING: 10090.ENSMUSP00000099820

    UniGene: Mm.263639