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  4. Recombinant Mouse Somatoliberin (Ghrh)

Recombinant Mouse Somatoliberin (Ghrh)

  • 中文名称：
    小鼠Ghrh重组蛋白
  • 货号：
    CSB-YP009412MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Ghrh重组蛋白
  • 货号：
    CSB-EP009412MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Ghrh重组蛋白
  • 货号：
    CSB-EP009412MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Ghrh重组蛋白
  • 货号：
    CSB-BP009412MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Ghrh重组蛋白
  • 货号：
    CSB-MP009412MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ghrh
  • Uniprot No.：
  • 别名：
    Ghrh; Somatoliberin; Growth hormone-releasing factor; GRF; Growth hormone-releasing hormone; GHRH
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Cytoplasmic domain
  • 表达区域：
    31-72
  • 氨基酸序列
    HVDAIFTTNY RKLLSQLYAR KVIQDIMNKQ GERIQEQRAR LS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone.
  • 基因功能参考文献：
    1. Growth hormone-releasing hormone agonist markedly improve therapeutic angiogenesis in hindlimb ischemia by increasing the viability and mobility of mesenchymal stem cells. PMID: 26868211
    2. The increased food intake observed in GHRH ablated animals is associated with increased locomotor and thermogenic activity. PMID: 25588992
    3. exerts survival and antiapoptotic effects in skeletal muscle cells through the activation of anabolic pathways and the inhibition of proteolytic routes PMID: 26110916
    4. In male mice GHRH deficiency brings about an increased physical activity and decreased anxiety- and depression-related behaviour, possibly related to increased TRH and decreased NE levels in the brain. PMID: 25028079
    5. These data suggest that ghrelin increases GHRH neuron excitability by increasing action potential firing rates and decreasing the strength of GABA inputs, leading to enhanced GHRH release; and that obestatin counteracts ghrelin actions. PMID: 21777303
    6. GHRH stimulated the NF-kappa b transcription factor, which is not only known to activate angiogenic factors but also the expression of genes involved in encoding enzymes in the prostaglandin-synthesis pathway such as COX-2 and the iNOS PMID: 20518847
    7. Findings establish a novel ontogenetic profile for GHRH neurons and suggest previously undiscovered roles for peripubertal gonadal factors in establishing population size in both sexes. PMID: 21159856
    8. treatment with a GHRH antagonist has positive effects on some aspects of aging, including an increase in telomerase activity. PMID: 21135231
    9. Review. Growth hormone-releasing hormone (GHRH) is a hypothalamic hormone that is essential for normal expansion of the somatotrope lineage during pituitary development. PMID: 12511850
    10. GHRH plays a crucial role in the development of experimental autoimmune encephalomyelitis. PMID: 12960295
    11. Efficient production of mature GHRH from pro-GHRH is a stepwise process mediated predominantly by furin at the N-terminal cleavage site followed by PC1/3 at the C terminus PMID: 14684599
    12. ablation of the GHRH gene causes isolated growth hormone deficiency in mice PMID: 15155578
    13. growth hormone (GH) deficiency responds to GH-releasing hormone (GHRH), even when this factor is absent during intrauterine development PMID: 15564325
    14. a splice variant of GHRH receptor designated SV1 may play a role in normal mouse physiology PMID: 16781787
    15. co-localization of peptides and enzyme in GHRH-eGFP neurons displays a sexual dimorphism at 3-month of age for neurotensin, & at 8-month for tyrosine hydroxylase, while the total number of GHRH-eGFP neurons does not exhibit gender difference at either age PMID: 17137749
    16. GHRH neurons are involved in aging of the GH axis. Aging had a subtle effect at the nerve terminal level in GHRH neurons, contrasting with the view that neuronal aging is accompanied by more widespread damage. PMID: 17328688

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Glucagon family
  • 数据库链接：

    KEGG: mmu:14601

    STRING: 10090.ENSMUSP00000029172

    UniGene: Mm.389327