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  4. Recombinant Mouse Somatotropin (Gh1)

Recombinant Mouse Somatotropin (Gh1)

  • 货号：
    CSB-YP009407MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP009407MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP009407MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP009407MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP009407MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Gh1; Gh; Somatotropin; Growth hormone
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    27-216
  • 氨基酸序列
    FPAM PLSSLFSNAV LRAQHLHQLA ADTYKEFERA YIPEGQRYSI QNAQAAFCFS ETIPAPTGKE EAQQRTDMEL LRFSLLLIQS WLGPVQFLSR IFTNSLMFGT SDRVYEKLKD LEEGIQALMQ ELEDGSPRVG QILKQTYDKF DANMRSDDAL LKNYGLLSCF KKDLHKAETY LRVMKCRRFV ESSCAF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
  • 基因功能参考文献：
    1. The results indicate that increased circulating GH is associated with a reduced ovarian primordial follicle reserve and increased pFoxO3a content in oocytes. PMID: 27771355
    2. These results indicate that up-regulation of GH in the lungs of DJ-1 KO mice may enhance the malignancy of B16F10 cells and nodule formation in pulmonary metastasis of melanoma. PMID: 27825319
    3. Confirmation of the impairment of GH-IGF-1 release in hyperphagic MC4R KO mice suggests a role for insulin in regulating both the release of GH, but also in mediating growth during periods of physiologically suppressed GH-IGF-1 levels PMID: 27558671
    4. When charged with hypoxia-ischemia, mutant brains with deleted IGF-1 receptor were broadly protected from cell damage, neuroinflammation and cerebral edema. PMID: 26762506
    5. Thiol-disulfide exchange reactions in hGH and related model peptides were influenced by higher order structure, by the size of the thiol reactant and by an Arg residue adjacent to Cys in the thiol reactant. PMID: 26887678
    6. Growth hormone deficient mice exhibited renal hypertrophy in tubular epithelial cells. PMID: 26997624
    7. observations demonstrate that germline loss of ghrelin-O-acyltransferase alters Growth Hormone release and patterning PMID: 26442444
    8. alter miR-19b concentrations in hematopoietic stem cells (HSCs) and affect HSC migration PMID: 26465715
    9. Moderate elevations in circulating GH and IGF-I can directly increase basal insulin secretion without impacting beta-cell mass, independent of changes in whole body insulin sensitivity and hyperlipidemia. PMID: 25936582
    10. Acylated ghrelin is not required for the surge in pituitary growth hormone observed in pregnant mice. PMID: 25645493
    11. STAT5 signaling is increased in the liver in GH-transgenic mice during the growth period, with a balance between positive and negative effectors resulting in accelerated but controlled growth. PMID: 25691498
    12. Our data indicate that FGF21 is important in the regulation of beta-cell proliferation and insulin synthesis, probably via modulation of GH signaling PMID: 25811804
    13. Hepatic GH actions normally serve to inhibit de novo lipogenesis (DNL), where loss of this inhibitory signal may explain, in part, the inappropriate increase in hepatic DNL observed in NAFLD patients. PMID: 26015548
    14. The effects of osteocalcin on testosterone and on induction of the growth hormone/insulin-like growth factor-1 axis, were investigated. PMID: 24691732
    15. The development of GH excess induced liver-, kidney-, and pituitary gland-alterations in GH transgenic mice are independent of IGF1 whereas GH- stimulated body growth depends on IGF1. PMID: 25017732
    16. The role of somatostatin in the expression of growth hormone in male and female mice is reported. PMID: 25551181
    17. Data suggest that Gh represses H6pd (hexose-6-phosphate dehydrogenase) through locally produced Igf1 (insulin-like growth factor 1); Gh directly represses Hsd11b1 (11-beta-hydroxysteroid dehydrogenase 1) mRNA rather than acting via Igf1 receptor. PMID: 24759003
    18. GH resistance dramatically exacerbates liver fibrosis in model of inflammatory cholestasis PMID: 25179284
    19. These results further support a role of GH/IGF-I in regulating mammary tumorigenesis but suggest the ultimate consequences of GH/IGF-I on breast tumor development are dependent on the diet and/or metabolic status. PMID: 25085903
    20. Exposure of mGH to UV light results in a wide spectrum of chemical modifications with immunogenic consequences. PMID: 24758742
    21. Ghrelin is a regulator of GH pulse amplitude in growing mice. PMID: 24949662
    22. robust GH-stimulated hepatic Igf1 gene transcription utilizes tissue-specific mechanisms of epigenetic regulation that are established independent of GH signaling. PMID: 24109593
    23. Data (including data from knockout mice) suggest that GH/GH receptor signaling in liver plays important roles in body size and body composition throughout life; in addition, liver-derived Igf1 (somatomedin) is important for normal body growth. PMID: 24517230
    24. The GH/IGF milieu does impact the growth of PTEN-deficient dysplastic prostatic cells. PMID: 23689346
    25. growth hormone resistance in adipocytes reduced lipolysis and increased body fat. PMID: 23782652
    26. Growth hormone seems to be necessary for the increased adipose p53 expression and for insulin resistance of obese mice. PMID: 23913444
    27. In vivo knockdown of SIRT1 in the liver restored the fasting-induced decrease in serum IGF-I levels and enhanced the GH-dependent increase in IGF-I levels, indicating that SIRT1 negatively regulates GH-dependent IGF-I production in the liver. PMID: 23980167
    28. the increased expression of FGF21 during chronic undernutrition inhibits GH action on chondrocytes by activating LEPROT and LEPROTL1. PMID: 23940039
    29. Data from mouse strain (Y*; created by genetic recombination) suggest neural GH of hypothalamic preoptic area is involved in mechanism by which sex chromosome dosage affects appetite regulation, increase in body weight, and susceptibility to obesity. PMID: 23861378
    30. The prolonged exposure to Growth hormone induces in the liver alterations in signaling pathways involved in cell growth, proliferation and survival. PMID: 23428905
    31. Specific removal of GHR in adipose tissue is sufficient to increase adipose tissue and decrease circulating adipsin. PMID: 23349524
    32. Microarray revealed 116 genes to be up or down regulated in the cochlea between young and old animals, the most prominent being prolactin (108.2 fold increase) and growth hormone (43.94 fold increase). PMID: 23010755
    33. Increased adiposity and insulin level is associated with the suppression of pulsatile GH secretion during weight gain. PMID: 23708999
    34. Data indicate a putative hypoxia response element (HRE) in the growth hormone (GH) promoter at the region -176 bp to -172 bp that contains a copy of the hypoxia-inducible factor-1 (Hif-1) binding motif (5'-ACGTG-3'). PMID: 23639351
    35. Targeted deletion of growth hormone (GH) receptor in macrophage reveals novel osteopontin-mediated effects of GH on glucose homeostasis and insulin sensitivity in diet-induced obesity. PMID: 23595986
    36. STAT5 proteins prevent progressive fatty liver disease and the formation of aggressive hepatocellular carcinoma in the setting of hyperactivated GH signaling. They play a key role in controlling systemic inflammation and regulating organ and body size. PMID: 22031092
    37. Reciprocal relationships between GH signaling and longevity discovered in mutant mice are discussed in this review and apply also to normal mice and other mammalian species. PMID: 21852148
    38. CST inhibited GH and adrenocorticotropin-hormone axes in a gender-dependent fashion. PMID: 21971153
    39. Elevated endogenous GH promotes lean mass and whole-body lipid oxidation but has minimal effects on adiposity PMID: 21990313
    40. GH-induced hepatic FGF21 production is mediated by FFA released from adipose tissues, and elevated FGF21 in turn acts as a negative feedback signal to terminate GH-stimulated lipolysis in adipocytes PMID: 21849508
    41. Data suggest that the induction of isoforms of the GH molecule in cells of the immune system may be an important mechanism of adaptation and/or protection of lymphoid cells under conditions of oxidative stress. PMID: 21741628
    42. Hepatic STAT5/GR signaling is crucial for the maintenance of systemic lipid homeostasis. PMID: 21725989
    43. Data show that the pituitary gland contributes to the sexually dimorphic patterns of growth hormone secretion that play an important role in differences in growth and metabolism between the sexes. PMID: 21098290
    44. sterol regulatory element-binding protein (SREBP)-1a links growth hormone action to lipid metabolism in hepatocytes PMID: 20863500
    45. Nadir-to-peak distribution of plasma GH concentration in mice was similar to other mammals, and that nycthemeral and sex differences existed as well. We found handling stress to be a potent immediate downregulator of circulating GH. PMID: 21045135
    46. Despite normal plasma free fatty acids and minimal obesity, absent growth hormone activation leads to steatosis because activated STAT5 prevents hepatic steatosis. PMID: 21084450
    47. the actions of GH on ZEB2 and P- and E-cadherin expression play a role in the pathogenesis of microalbuminuria of DN. PMID: 20682777
    48. The serum balance in liver IGF-1-deficient mice that favors GH over IGF-1 diminished the effects of ablated ovarian function on numbers of osteoclast precursors in the marrow and viability of osteocytes within the cortical matrix PMID: 19619004
    49. Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice PMID: 20231469
    50. loss of STAT5 sensitizes hepatocytes to bile acid-induced damage and apoptosis caused by disruption of GH-induced transcription of Igf-1 and down-regulation of hepatoprotective genes. PMID: 20162728

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Somatotropin/prolactin family
  • 数据库链接：

    KEGG: mmu:14599

    STRING: 10090.ENSMUSP00000099360

    UniGene: Mm.343934