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  4. Recombinant Mouse Sororin (Cdca5)

Recombinant Mouse Sororin (Cdca5)

  • 货号：
    CSB-YP866574MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP866574MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP866574MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP866574MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP866574MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cdca5
  • Uniprot No.：
  • 别名：
    Cdca5Sororin; Cell division cycle-associated protein 5
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-264
  • 氨基酸序列
    MAERRTRSGG AAQRSGPRTS LTKPSKSSKR KSGSDLPNSF SEIWPRTTPA VPVRKAIVLK KIVAHAVEVP DVHTVRRSPR ISFILEKENN PPLKVPTKED LFKTCSVPGT PSSTPVLYTQ NVEPDSGEAE LDSRDLEMSQ KVRRSYSRLQ SLGCASTSTP GRRSFFGFEG PDDLPGVSPV VCSKLIETPK VPAKDLVPAR TKDLVPDSTK DLVPARTLPG ISPPVVKEKR KKKVPEILKS ELDKWAVAMN AEFEAAEQFE LLIE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair.
  • 基因功能参考文献：
    1. Results indicate that Sororin regulation during meiosis is distinct from its regulation in mitotic cells and may suggest that it interacts with a distinctly different partner to ensure proper chromosome dynamics in meiosis. PMID: 28050734
    2. Our results define Sororin as a determinant during mouse oocyte meiotic maturation by favoring DNA damage repair and chromosome separation, and thereby, maintaining the genome stability and generating haploid gametes. PMID: 27826797
    3. The s show that sororin is essential for embryonic development, cohesion maintenance, and proper chromosome segregation. PMID: 26903600
  • 亚细胞定位：
    Nucleus. Chromosome. Cytoplasm. Note=Associates with nuclear chromatin from S phase until metaphase and is released in the cytoplasm upon nuclear envelope breakdown.
  • 蛋白家族：
    Sororin family
  • 数据库链接：

    KEGG: mmu:67849

    STRING: 10090.ENSMUSP00000025704

    UniGene: Mm.23526