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  4. Recombinant Mouse Spartin (Spg20)

Recombinant Mouse Spartin (Spg20)

  • 货号：
    CSB-YP819170MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP819170MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP819170MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP819170MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP819170MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Spart; Kiaa0610; Spg20; Spartin
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-671
  • 氨基酸序列
    MEREPENGEP AEIKIIKEAY EKAFMFVNKG LNTDELGQKE EAKNYYKQGI GHLLRGISIA AAEPGHTGPA WEAARQMQQK MKETLQNVRT RLEILEKGLA TSLRNDLQDV PKLYPEFPPK DACKKSPEQE SVSTAPQRAE VDGSASAACA GPSGAPSALP VPSPSCPAEA PPAYSPQAAE GHYTVSYGTD SGEFSSVGED FYRNRSQPPP LETLGLDADE LILIPNGVQI FFVNPAGEVS APSYPGYLRI VRFLDNSLDT VLNRPPGFLQ VCDWLYPLVP DRSPVLKCTV GAYMFPDTML QAAGCFVGVV LSSELPEDDR ELFEDLLRQM SDLRLQANWN REEDEFQIPG RSSHPSEPPK EASGTDVRQS SSSGSSIDQG SKDARHKGKR GKKTKDSSEE VNLSQIVPCE PSSEEKSKEL PEWSEKVAHN ILSGASWVSW GLVKGAEFTG KAIQKGASKL RERIQPEEKP VEVSPAVTRG LYIAKQATGG AAKVSQLLVD GVCTVANCVG KELAPHVKKH GSKLVPESLK RDKDGKSALD GAMVVAASSV QGFSTVWQGL ECAAKCIVNN VSAETVQTVR YKYGHNAGEA THNAVDSAIN VGLTAYNIDN IGIKAMVKKT AKQTGHTLLE DYQIVERPQR ESQGGATSTE GRRDIGKQVE EEKPGAGKKD K
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis.
  • 基因功能参考文献：
    1. Here we report the case of three patients of Filipino descent with Troyer syndrome. Whole exome sequencing (WES) identified a homozygous mutation c.364_365delAT which predicts p.Met122Valfs*2 in SPG20 PMID: 27112432
    2. findings evidence a positive correlation between SIRT1 and BCL6 expression increase in follicular lymphomas (FL) . SIRT1 methylation decreases in FL and diffuse large-B cell lymphomas (DLBCL)and this parallels the increase of KLF4, DAPK1 and SPG20 methylation PMID: 28324774
    3. spartin, via the ubiquitin-binding region, binds Lys-63-linked ubiquitin chains but does not bind Lys-48-linked ubiquitin chains. spartin's role in DALIS formation depends on key residues within its ubiquitin-binding region. PMID: 24523286
    4. alsin and spartin may interact each other physically PMID: 22982304
    5. a role for spartin in lipid droplets maintenance and in the regulation of cytokinesis PMID: 22619377
    6. SPG20 protein spartin associates with cardiolipin via its plant-related senescence domain and regulates mitochondrial Ca2+ homeostasis PMID: 21559443
    7. Our results suggest that spartin might be involved in endocytosis, vesicle trafficking, or mitogenic activity, and that impairment in one of these processes may underlie the long axonopathy in patients with Troyer syndrome. PMID: 16036216

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  • 亚细胞定位：
    Cytoplasm. Midbody.
  • 数据库链接：

    KEGG: mmu:229285

    STRING: 10090.ENSMUSP00000042367

    UniGene: Mm.235523