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  4. Recombinant Mouse Speedy protein A (Spdya)

Recombinant Mouse Speedy protein A (Spdya)

  • 货号：
    CSB-YP683296MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP683296MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP683296MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP683296MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP683296MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Spdya
  • Uniprot No.：
  • 别名：
    Spdya; Spdy1; Speedy protein A; Protein expressed in male leptotene and zygotene spermatocytes 465; MLZ-465; Rapid inducer of G2/M progression in oocytes A; RINGO A; mSpy/Ringo A; Speedy-1; Spy1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-310
  • 氨基酸序列
    MRHNQMYCET PPTVTIHVKS GSNRSHQTRK PISLKRPILK DSWEASENNA QNNKSKRPRG PCLIIQRQEM TAFFKLFDDD LIQDFLWMDC CCKIADKYLL AMTFVYFKRA KFTINEHTRI NFFIALYLAN TVEEDEEEAK YEIFPWALGK NWRKLFPNFL KLRDQLWDRI DYRAIVSRRC CEEVMAIAPT HYIWQRERSV HHSGAVRNYN RDEVHLPRGP SATPVDCSLC GKKGRYVRLG LSSSSSSSSD TGELMEKDSQ ELHSAFSVDT AGDPPHTYSQ VANDHQSNKE NETNFVKKNK SVEWFAESEE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1 and CDK2. Contributes to CDK2 activation without promoting CDK2 phosphorylation, by inducing a conformation change of the CDK2 T-loop that obstructs the substrate-binding cleft prior to kinase activation. Interferes with CDKN1B-mediated inhibition of CDK2. Mediates cell survival during the DNA damage process through activation of CDK2.
  • 基因功能参考文献：
    1. Identified a telomere localization domain on Speedy A covering the distal N terminus and the Cdk2-binding Ringo domain, and this domain is essential for the localization of Speedy A to telomeres. PMID: 28031483
    2. RingoA is an important activator of Cdk2 at meiotic telomeres. PMID: 27025256
    3. the Spy1/RINGO family of proteins may play an essential role in regulating both normal and abnormal growth processes in the breast PMID: 18483240
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Speedy/Ringo family
  • 组织特异性：
    Expressed at a high level in testis. Also expressed in the adult ovary and in immature oocytes.
  • 数据库链接：

    KEGG: mmu:70891

    STRING: 10090.ENSMUSP00000118994

    UniGene: Mm.477599