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  4. Recombinant Mouse Stathmin (Stmn1)

Recombinant Mouse Stathmin (Stmn1)

  • 中文名称：
    小鼠Stmn1重组蛋白
  • 货号：
    CSB-YP022857MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Stmn1重组蛋白
  • 货号：
    CSB-EP022857MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Stmn1重组蛋白
  • 货号：
    CSB-EP022857MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Stmn1重组蛋白
  • 货号：
    CSB-BP022857MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Stmn1重组蛋白
  • 货号：
    CSB-MP022857MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Stmn1; Lag; Lap18; Pr22; Stathmin; Leukemia-associated gene protein; Leukemia-associated phosphoprotein p18; Metablastin; Oncoprotein 18; Op18; Phosphoprotein p19; pp19; Prosolin; Protein Pr22; pp17
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-149
  • 氨基酸序列
    ASSDIQVKE LEKRASGQAF ELILSPRSKE SVPDFPLSPP KKKDLSLEEI QKKLEAAEER RKSHEAEVLK QLAEKREHEK EVLQKAIEEN NNFSKMAEEK LTHKMEANKE NREAQMAAKL ERLREKDKHV EEVRKNKESK DPADETEAD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear.
  • 基因功能参考文献：
    1. These findings suggest that during embryo implantation, knockdown of Stmn1 suppresses decidualisation by inhibiting the expression of p-Akt, HIF-1alpha and VEGF, thus leading to impaired embryo implantation. PMID: 27456758
    2. The data suggest that STMN1 mediates the progesterone production by modulating the promoter activity of Star and Cyp11a1. PMID: 27270953
    3. EGFR suppression of mitotic regulators including Rcc2 and Stathmin 1 are a mechanism for catagen induction in mouse skin PMID: 26661905
    4. We identified stathmin as a key molecule aiding in septin-independent cytokinesis, demonstrated that stathmin supplementation is sufficient to override cytokinesis failure in SEPT7-null fibroblasts PMID: 25122120
    5. Overexpressing stathmin reduces complement receptor 3-mediated phagocytosis and cellular activation, implicating a pivotal inhibitory role for stathmin in classically activated macrophages. PMID: 26082487
    6. Stathmin cooperates with p27(kip1) to control the early phase of G1 to S phase transition and that this function may be of particular relevance in the context of tumor progression. PMID: 25486569
    7. The protein profiles during murine embryo implantation were clarified. Stathmin 1 might be a potential regulator of embryo implantation. PMID: 25866183
    8. Results show an important role for stathmin during adult neurogenesis in the subgranular zone of the mouse hippocampus; propose that stathmin controls the transition from neuronal precursors to early postmitotic neurons PMID: 24909416
    9. Stathmin mutations disrupt changes in microtubule stability, GluA2 localization, synaptic plasticity and memory. PMID: 25007915
    10. Stmn deletion does not prolong the lifespan of spinal muscular atrophy-like mice, suggesting that stathmin dysregulation and microtubule disruption are not a cause but rather a consequence of SMA pathology. PMID: 23268200
    11. stathmin expression is dispensable for tumor onset, at least in mice, thus making stathmin a virtually exclusive marker of aggressive disease and a promising therapeutic target for advanced cancers. PMID: 23029098
    12. results demonstrate the mechanism of stathmin-dependent control of MT dynamics, Rho signaling, and permeability PMID: 22700873
    13. Stathmin phosphorylates the microtubule network during T cell activation, resulting in increased microtubule growth rate dependent on the presence of stathmin. PMID: 22529300
    14. GRPR and stathmin control in opposite directions both cued fear extinction and neural activities of the amygdala and prefrontal cortex PMID: 22312434
    15. Stathmin, which alters microtubule dynamics, plays an essential role in maintenance of postnatal bone mass by regulating both osteoblast and osteoclast functions in bone. PMID: 21557310
    16. These results provide evidence that stathmin-1 expression in uNK cells at the maternal-fetal interface may help modulate uterine natural killer cell function and may be beneficial for a successful pregnancy. PMID: 21281784
    17. Aberrant stathmin levels may play a detrimental role in spinal muscular atrophy. PMID: 20176735
    18. results suggest that up-regulation of stathmin1 in the dentate gyrus, secondary to PACAP deficiency, may create abnormal neuronal circuits that cause abnormal behavior PMID: 20062533
    19. STMN1 expression is enhanced by TCDD, and may be involved in accelerated eye opening, probably by stimulating proliferation of corneal epithelial cells. PMID: 20385220
    20. The Ggamma-globin-Tag model and other SV40/T-antigen driven transgenic mouse models may be useful for testing potential therapies directed at stathmin-1 in human prostate tumors. PMID: 20058236
    21. Data support a model in which stathmin functions in interphase to control the partitioning of tubulins between dimer and polymer pools by setting the number of microtubules per cell. PMID: 19515833
    22. findings suggest that stathmin plays an essential role in the maintenance of axonal integrity PMID: 11839567
    23. downregulation in response to genotoxic stress and interaction of E2F PMID: 12446714
    24. stathmin expression is necessary for the proliferation and differentiation of early megakaryoblasts and its suppression in the later stages of megakaryocytic maturation is necessary for polyploidization. PMID: 12763137
    25. Vezf1 is involved in the regulation of angiogenesis, at least in part, through the expression of stathmin/OP18 in ECs. PMID: 15031128
    26. stathmin expression is disregulated, and Hsp25, Hsp27, and peroxiredoxin 6 are upregulated in a mouse model of familial amyotrophic lateral sclerosis PMID: 15509539
    27. stathmin plays a permissive role in GnRH cell motility, possibly via modulation of cadherins expression. PMID: 15625246
    28. Data show that cytoplasmic expression of p27(kip1) affects microtubule stability following cell adhesion on extracellular matrix, and that this activity is due to its ability to bind and impair the function of the MT-destabilizing protein stathmin. PMID: 15652749
    29. We studied whether stathmin was expressed in pathological conditions associated with myelin dysfunction. PMID: 15659612
    30. Stathmin is required for the induction of long-term potentiation in afferent inputs to the amygdala and is essential in regulating both innate and learned fear. PMID: 16286011
    31. The NF-Y site at -65 accounts for greater than 60% of the Op18 gene expression. PMID: 16757134
    32. Stathmin expression is highest when the prostate is undergoing morphogenesis or tumorigenesis and these processes may be regulated through differential phosphorylation. PMID: 17455228
    33. The inhibition of stathmin expression and function may be useful in limiting the spread of malignant gliomas within the brain. PMID: 18593927
    34. findings implicate stathmin as the critical molecular component linking the BLA-associated neural circuitry with innate parental behaviors and adult social interactions PMID: 18794533
    35. Loss of STMN1 is correlated with expression changes to genes encoding proteins functioning in cell motility pathways. PMID: 19643027
    36. Data suggest that regulation of NDRG1 and stathmin by phosphorylation at specific Ser/Thr residues may participate in the cellular response induced by proteasome inhibitors. PMID: 19688729

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Stathmin family
  • 组织特异性：
    Highly expressed in the lateral nucleus of the amygdala.
  • 数据库链接：

    KEGG: mmu:16765

    STRING: 10090.ENSMUSP00000030636

    UniGene: Mm.378957