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  4. Recombinant Mouse Steroid hormone receptor ERR2 (Esrrb)

Recombinant Mouse Steroid hormone receptor ERR2 (Esrrb)

  • 货号：
    CSB-YP730742MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP730742MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP730742MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP730742MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP730742MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Esrrb; Err-2; Err2; Nr3b2Steroid hormone receptor ERR2; Estrogen receptor-like 2; Estrogen-related receptor beta; ERR-beta; Nuclear receptor subfamily 3 group B member 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-433
  • 氨基酸序列
    MSSEDRHLGS SCGSFIKTEP SSPSSGIDAL SHHSPSGSSD ASGGFGIALS THANGLDSPP MFAGAGLGGN PCRKSYEDCT SGIMEDSAIK CEYMLNAIPK RLCLVCGDIA SGYHYGVASC EACKAFFKRT IQGNIEYNCP ATNECEITKR RRKSCQACRF MKCLKVGMLK EGVRLDRVRG GRQKYKRRLD SENSPYLNLP ISPPAKKPLT KIVSNLLGVE QDKLYAMPPN DIPEGDIKAL TTLCELADRE LVFLINWAKH IPGFPSLTLG DQMSLLQSAW MEILILGIVY RSLPYDDKLA YAEDYIMDEE HSRLVGLLDL YRAILQLVRR YKKLKVEKEE FMILKALALA NSDSMYIENL EAVQKLQDLL HEALQDYELS QRHEEPRRAG KLLLTLPLLR QTAAKAVQHF YSVKLQGKVP MHKLFLEMLE AKV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5'TCAAGGTCA-3' localized on promoter and enhancer of targets genes regulating their expression or their transcriptional activity. Plays a role, in a LIF-independent manner, in maintainance of self-renewal and pluripotency of embryonic and trophoblast stem cells through different signaling pathways including FGF signaling pathway and Wnt signaling pathways. Upon FGF signaling pathway activation, interacts with KDM1A by directly binding to enhancer site of ELF5 and EOMES and activating their transcription leading to self-renewal of trophoblast stem cells. Also regulates expression of multiple rod-specific genes and is required for survival of this cell type. Plays a role as transcription factor activator of GATA6, NR0B1, POU5F1 and PERM1. Plays a role as transcription factor repressor of NFE2L2 transcriptional activity and ESR1 transcriptional activity. During mitosis remains bound to a subset of interphase target genes, including pluripotency regulators, through the canonical ESRRB recognition (ERRE) sequence, leading to their transcriptional activation in early G1 phase. Can coassemble on structured DNA elements with other transcription factors like SOX2, POU5F1, KDM1A and NCOA3 to trigger ESRRB-dependent gene activation. This mechanism, in the case of SOX2 corecruitment prevents the embryonic stem cells (ESCs) to epiblast stem cells (EpiSC) transition through positive regulation of NR0B1 that inhibits the EpiSC transcriptional program. Also plays a role inner ear development by controlling expression of ion channels and transporters and in early placentation.
  • 基因功能参考文献：
    1. The resulting cells express the components of the core transcriptional network of mESCs, including ESRRB, at high levels, which suggests the existence of naive-state hiPSCs that are similar to mESCs. We also demonstrate that these cells differentiate more readily into neural cells than do conventional hiPSCs. PMID: 29129686
    2. Taken together these observations suggest that ESRRbeta is a critical component in the onset of Ddilated cardiomyopathy by affecting contractility and calcium balance PMID: 28130335
    3. Findings indicate that the Gata6 promoter is activated by Esrrb in association with Ncoa3, and Dax1 inhibited activities of Esrrb and Ncoa3, resulting maintenance of the undifferentiated status of embryonic stem (ES) cells. PMID: 27601327
    4. mitotic Esrrb binding is highly dynamic, driven by specific recognition of its DNA-binding motif and is associated with early transcriptional activation of target genes after completion of mitosis PMID: 27723719
    5. JARID2 physically interacts with ESRRB, SALL4A, and PRDM14 PMID: 26523946
    6. interacts in trophoblast stem cells with the histone demethylase Lsd1 and with the RNA Polymerase II-associated Integrator complex PMID: 26206133
    7. The forced expression of Essrb (and Nanog) resulted in the dispensability of nucleostemin expression in embryonic stem cells. PMID: 25522312
    8. Daily regulation of Esrrb in photoreceptor cells may contribute to their adaptation to 24-h changes in metabolic demands. PMID: 25737630
    9. Loss of Errbeta affects body composition, neuropeptide levels, stress hormones, and centrally-modulated startle responses of mice. PMID: 24053666
    10. Esrrb selective deletion in the hindbrain alters neuropeptide Y expression, whole-body energy level and ingestive behavior. PMID: 23360481
    11. Dax1 functions as a negative regulator of Esrrb and Oct3/4, and these molecules form a regulatory loop for controlling the pluripotency and self-renewal capacity of embryonic stem cells. PMID: 23508100
    12. a direct Nanog target gene that can substitute for Nanog function in pluripotent cell PMID: 23040477
    13. a pivotal target of the Gsk3/Tcf3 axis regulating embryonic stem cell self-renewal PMID: 23040478
    14. Esrrb forms a heterodimer complex with Sox2 in ES cells to regulate transcriptional differences between mouse embryonic and epiblast stem cells. PMID: 23169531
    15. we present evidence that chondrolectin (Chodl) is expressed by fast motor neurons and that estrogen-related receptor beta (ERRbeta) is a candidate marker for slow motor neurons in the spinal cord PMID: 20437528
    16. ERRbeta is a critical regulator of rod photoreceptor function and survival PMID: 20534447
    17. Data demonstrate that estrogen-related receptor (ERR) beta is transiently induced, and ERRgamma is dramatically induced (and accumulates) in a differentiation-dependent manner in skeletal muscle cells. PMID: 19631715
    18. estrogen receptor beta knockout females exhibit lordosis behaviour equal to that of wild-type females PMID: 12969243
    19. ERbeta was predominantly localized in the magnocellular divisions of PVN. In the pregnant female brain. andcirculating sex steroids may differentially regulate the expression of ERbeta in the PVN of mice. PMID: 14715153
    20. Loss of primordial germ cells-specific expression of ERR-beta results in reduction of germ cell number in mouse embryos PMID: 15003627
    21. Nr3b2 controls epithelial cell fate and endolymph production by the stia vascularis. PMID: 17765677
    22. Esrrb is recruited near the Oct-Sox element in the Nanog proximal promoter, where it positively regulates Nanog expression. PMID: 18662995
    23. Esrrb coordinates with Nanog and Oct4 to activate the internal machinery of ES cells PMID: 18957414
    24. In ES cells, Esrrb targets many genes involved in self-renewal and pluripotency. This suggests that Esrrb may mediate reprogramming through the upregulation of ES-cell-specific genes. PMID: 19136965

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Chromosome.
  • 蛋白家族：
    Nuclear hormone receptor family, NR3 subfamily
  • 组织特异性：
    Highly expressed in undifferentiated ESCs. Expressed in immature horizontal cells and in rod photoreceptors at intermediate and late stages of differentiation. Expressed in endolymph-producing epithelial cells.
  • 数据库链接：

    KEGG: mmu:26380

    STRING: 10090.ENSMUSP00000105833

    UniGene: Mm.235550