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  4. Recombinant Mouse Steroid receptor RNA activator 1 (Sra1)

Recombinant Mouse Steroid receptor RNA activator 1 (Sra1)

  • 货号：
    CSB-YP022648MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP022648MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP022648MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP022648MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP022648MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Sra1
  • Uniprot No.：
  • 别名：
    Sra1; Steroid receptor RNA activator 1; Steroid receptor RNA activator protein; SRAP
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-232
  • 氨基酸序列
    MMRCPAGGAE VEMAELYVKP GNKERGWNDP PQFSYGLQTQ TGGPKRTPLT KRVAAPQDGS PRAPETSGPP PVDHPPPSSK ASRPPPMGSC PATGVEPPSS PVIESETLIE DVLRPLEQAL EDCHGHTKKQ VCDDISRRLA LLREQWAGGK LSIPVKKRMA LLVQELLHHQ WDAADDIHRS LMVDHVTEVS QWMVGVKRLI AEKKSLSSEE TKEEKFTVEP ENQTIPGFQQ PS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis.
  • 基因功能参考文献：
    1. Visfatin upregulated CD36 and SRA expression and downregulated ABCA1 and ABCG1 expression, subsequently increased ox-LDL uptake and decreased cholesterol efflux, and finally promoted foam cell formation via the PI3K- and ERK-dependent pathways. PMID: 26536203
    2. The results of this study demonstrated that SRA could attenuate microglia mediated inflammation injury in ICH. In addition, SRA mediated negative feedback mechanism in neuroimmune homeostasis. PMID: 25481196
    3. these data are the first to indicate a functional role for SRA in adipose tissue biology and glucose homeostasis in vivo. PMID: 24675075
    4. Dax1 augmentation of LRH-1-mediated Oct4 activation is dependent upon steroid receptor RNA activator PMID: 20943815
    5. DEAD-box RNA helicase p68 (DDX5) and its associated noncoding RNA, steroid receptor RNA activator (SRA), form a complex with CTCF that is essential for insulator function PMID: 20966046
    6. Steroid receptor RNA activator stimulates proliferation as well as apoptosis in vivo PMID: 14517287
    7. Results identify a pseudouridine synthase, mPus1p, as a coactivator for retinoic acid receptor (mRAR)gamma when coexpressed with steroid receptor RNA activator. PMID: 15327771
    8. both MARCO and SR-A could be involved in the positioning and differentiation of macrophages, possibly through interaction with endogenous ligands PMID: 16339556
    9. These findings reveal novel functions of SRA and Dax-1 in steroidogenesis and adrenal biology. PMID: 19188450

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    SRA1 family
  • 数据库链接：

    KEGG: mmu:24068

    STRING: 10090.ENSMUSP00000133360

    UniGene: Mm.29058