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  4. Recombinant Mouse Syncoilin (Sync)

Recombinant Mouse Syncoilin (Sync)

  • 货号：
    CSB-YP863637MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP863637MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP863637MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP863637MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP863637MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Sync
  • Uniprot No.：
  • 别名：
    Sync; Sync1; Syncoilin; Syncoilin intermediate filament 1; Syncoilin-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-470
  • 氨基酸序列
    MASPEPLRGG DGARASREPH TEASFPLQES ESPKEAKTFN PEATLSLEGT VNLEDILYLG ASGDFEESFY EEEYEKPALT LFIDESRQPD EALGLEEPVR PEEMLSVEES VTPDEVQISE QPVEPAKSPT ACEGEMVATE GSLPAQPIPN TEEDPLSVED LERLEARFQQ CVQAVSQLEE ERDQLIHELV LLREPALQEV QQVHQDILAA YKLHAQAELE RDGLREEIRT VKQKLFKVTK ECVAYQYQLE CRQQDVAQFA DCREALTTRA AQLSEELTQL RDACQKQKEQ LQQQLEAPPT QSDGHFLQES RRLSTQFENL MAESRQGLEE EYEPQLLRLL ERKEAGTKAL QDTQAEIQEM REALRPLEAE ARQLQLQNRN LEDQITLVRQ KRDEEVQQYR EQLEEMEERQ RQLRSGVQVQ QQKNKEMERL RMSLAEELST YKAMLPKSLE QADAPTSQAG GVEAQSPGTV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Atypical type III intermediate filament (IF) protein that may play a supportive role in the efficient coupling of mechanical stress between the myofibril and fiber exterior. May facilitate lateral force transmission during skeletal muscle contraction. Does not form homofilaments nor heterofilaments with other IF proteins.
  • 基因功能参考文献：
    1. in the liver, syncoilin is predominantly expressed by activated Hepatic stellate cells and displays very low-expression levels in other liver cell types, making it a good marker of activated Hepatic stellate cells. PMID: 24043511
    2. A neuronal analysis of the syncoilin-null mouse (Sync(-/-)) revealed a reduced ability in accelerating treadmill and rotarod tests. PMID: 20587592
    3. The data show that absence of alpha-dystrobrevin or desmin leads to dynamic changes in syncoilin that may compensate for, or participate in, different muscle myopathies. PMID: 17629480
    4. Syncoilin may play a supportive role for desmin in the efficient coupling of mechanical stress between the myofibril and muscle fiber exterior. PMID: 18367591
    5. A second viable syncoilin knockout model and highlights the importance of further investigations to determine the role of syncoilin in skeletal muscle. PMID: 18594912
    6. Despite lacking an apparent structural role in striated muscle, the three syncoilin isoforms are differentially and strongly upregulated during muscle regeneration and atrophy in C57BL/6 mice, possibly suggesting an atypical role for syncoilin in muscle. PMID: 19070665

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  • 亚细胞定位：
    Cytoplasm, perinuclear region.
  • 蛋白家族：
    Intermediate filament family
  • 组织特异性：
    Detected strongly in skeletal muscle and heart and weakly in lung (at protein level). Highly expressed in skeletal muscle and lung and weakly in lung and testis.
  • 数据库链接：

    KEGG: mmu:68828

    STRING: 10090.ENSMUSP00000099659

    UniGene: Mm.132243