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  4. Recombinant Mouse Syndecan-3 (Sdc3), partial

Recombinant Mouse Syndecan-3 (Sdc3), partial

  • 货号：
    CSB-YP731058MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP731058MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP731058MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP731058MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP731058MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Sdc3; Kiaa0468; Syndecan-3; SYND3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cell surface proteoglycan that may bear heparan sulfate. May have a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism.
  • 基因功能参考文献：
    1. Syndecan-3 ablation unexpectedly improves regeneration in repeatedly injured muscle and in dystrophic mice, accompanied by the persistence of sublaminar and interstitial, proliferating myoblasts PMID: 27757223
    2. This study shows a novel role for syndecan-3 in inflammation PMID: 25015005
    3. Syndecan-3 limits cocaine intake by modulating the effects of glial-cell-line-derived neurotrophic factor, which uses syndecan-3 as an alternative receptor. PMID: 23736082
    4. This study showed that the melanocortin agonist Melanotan II (MTII) potently suppresses food intake and activates the hypothalamic paraventricular nuclei (PVN) in SDC-3(-/-) mice based on c-fos immunoreactivity PMID: 20923696
    5. Syndecan-3 may directly transduce Glial cell line-derived neurotrophic factor (GDNF) family ligands (GFL) signals or serve as a coreceptor, presenting GFLs to the signaling receptor RET. PMID: 21200028
    6. The Syndecan-3 interacts with Notch and is required for Notch processing by ADAM17/tumor necrosis factor-alpha-converting enzyme (TACE) and signal transduction. PMID: 20696709
    7. Identification of the core protein carrying the Tn antigen in mouse brain: specific expression on syndecan-3. PMID: 11831359
    8. Syndecan-3 mRNA transcripts are expressed by reactive astrocytes in the region surrounding the necrotic brain tissue, exhibiting peak levels at day 7 after cryo-injury. PMID: 12112370
    9. syndecan-3 acts as an important modulator of synaptic plasticity that influences hippocampus-dependent memory. PMID: 12359158
    10. Data support the hypothesis that syndecan-3 modulates melanocortin activity via facilitation of agouti-related protein. PMID: 12851299
    11. hydrolysis is gamma-secretase dependent and modulates cytosolic signaling PMID: 14504279
    12. Syndecan-3(-/-) mice exhibit a novel form of muscular dystrophy characterized by impaired locomotion, fibrosis, and hyperplasia of myonuclei and satellite cells, suggesting a role of syndecan-3 in muscle development PMID: 15371336
    13. syndecan-3 has a role in the regulation of body weight and in obesity PMID: 15520868
    14. Data show that massive cell death of cultured dorsal root ganglion (DRG) neurons from mice deficient in the N-syndecan gene as compared with wild-type controls. PMID: 18766019

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Syndecan proteoglycan family
  • 数据库链接：

    KEGG: mmu:20970

    STRING: 10090.ENSMUSP00000065877

    UniGene: Mm.206536