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  4. Recombinant Mouse T-box transcription factor TBX19 (Tbx19)

Recombinant Mouse T-box transcription factor TBX19 (Tbx19)

  • 中文名称：
    小鼠Tbx19重组蛋白
  • 货号：
    CSB-YP858151MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Tbx19重组蛋白
  • 货号：
    CSB-EP858151MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Tbx19重组蛋白
  • 货号：
    CSB-EP858151MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Tbx19重组蛋白
  • 货号：
    CSB-BP858151MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Tbx19重组蛋白
  • 货号：
    CSB-MP858151MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tbx19
  • Uniprot No.：
  • 别名：
    Tbx19; Tpit; T-box transcription factor TBX19; T-box protein 19; T-box factor; pituitary
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-446
  • 氨基酸序列
    MSELATQKAG EGTVSRLLNV VESELQAGRE KGDPTEKQLQ IILEDAPLWQ RFKEVTNEMI VTKNGRRMFP VLKISVTGLD PNAMYSLLLD FVRTDSHRWK YVNGEWVPAG KPEVSSHSCV YIHPDSPNFG AHWMKAPISF SKVKLTNKLN GGGQIMLNSL HKYEPQVHIV RVGGAHRMVM NCSFPETQFI AVTAYQNEEI TALKIKYNPF AKAFLDAKER NHLKDVPEAI SESQHVTYSH LGGWILSNPD GVCTAANSNY QYATPLPLPA PHTHHGCEHY AGLRGHRQAP YPSAYMHRNH SPSVNLIESS SNNLQVFSGP DSWTSLSSTP HASILSVPHS NGPINPGPSP YPCLWTISNG GGGPVASGSE VHASTSGTIL LGNPAVTSPS SLLPTQATTS AGVEVLGEPS LTSIAVSTWT AVASHPLPGW GGPGGAGRHS SSSLDS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional regulator involved in developmental processes. Can activate POMC gene expression and repress the alpha glycoprotein subunit and thyroid-stimulating hormone beta promoters.
  • 基因功能参考文献：
    1. The coordinate expression of Etv1 with POMC cell differentiation and its interaction with the highly cell-restricted Tpit factor indicate that Etv1 participates in a combinatorial code for pituitary cell-specific gene expression. PMID: 21622576
    2. Review. Association of 2 mutations with an ACTH deficiency is consistent with the role of tbx19 in differentiation of POMC cells. PMID: 11916612
    3. TPIT has a role in expression of the pro-opiomelanocortin gene and terminal differentiation of the pituitary corticotroph lineage, and its mutation causes early onset pituitary ACTH deficiency PMID: 12651888
    4. Tpit has a role as a negative regulator of gonadotroph differentiation in developing mouse PMID: 12651892
    5. Tpit and NeuroD1 are not essential for early corticotroph commitment. There are different levels of control for commitment of POMC lineages compared to cell survival or to cell-specific transcription of POMC. PMID: 15666791
    6. the M86R TPIT mutation is defining an important surface of the T domain for multiple protein interactions and for transcription PMID: 17652218

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    KEGG: mmu:83993

    STRING: 10090.ENSMUSP00000027859

    UniGene: Mm.190649