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  4. Recombinant Mouse T-box transcription factor TBX20 (Tbx20)

Recombinant Mouse T-box transcription factor TBX20 (Tbx20)

  • 中文名称：
    小鼠Tbx20重组蛋白
  • 货号：
    CSB-YP875359MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Tbx20重组蛋白
  • 货号：
    CSB-EP875359MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Tbx20重组蛋白
  • 货号：
    CSB-EP875359MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Tbx20重组蛋白
  • 货号：
    CSB-BP875359MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Tbx20重组蛋白
  • 货号：
    CSB-MP875359MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tbx20
  • Uniprot No.：
  • 别名：
    Tbx20; Tbx12T-box transcription factor TBX20; T-box protein 20
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-445
  • 氨基酸序列
    MEFTASPKPQ LSSRANAFSI AALMSSGGPK EKEAAENTIK PLEQFVEKSS CAQPLGELTS LDAHAEFGGG GGSPSSSSLC TEPLIPTTPI IPSEEMAKIA CSLETKELWD KFHELGTEMI ITKSGRRMFP TIRVSFSGVD PESKYIVLMD IVPVDNKRYR YAYHRSSWLV AGKADPPLPA RLYVHPDSPF TGEQLLKQMV SFEKVKLTNN ELDQHGHIIL NSMHKYQPRV HIIKKKDHTA SLLNLKSEEF RTFIFPETVF TAVTAYQNQL ITKLKIDSNP FAKGFRDSSR LTDIERESVE SLIQKHSYAR SPIRTYGEED VLGEESQTTQ SRGSAFTTSD NLSLSSWVSS SSSFPGFQHP QPLTALGTST ASIATPIPHP IQGSLPPYSR LGMPLTPSAI ASSMQGSGPT FPSFHMPRYH HYFQQGPYAA IQGLRHSSAV MTPFV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a transcriptional activator and repressor required for cardiac development and may have key roles in the maintenance of functional and structural phenotypes in adult heart.
  • 基因功能参考文献：
    1. Collectively, our proteomic, biochemical, genetic, and structural studies suggest that the physical interaction between TBX20 and CASZ1 is required for cardiac homeostasis, and further, that reduction or loss of this critical interaction leads to dilated cardiomyopathy (DCM) PMID: 28945738
    2. chromatin analysis reveals that endocardial TBX20 has roles in septation PMID: 27348591
    3. Cardiomyocyte Tbx20 induced overexpression activates multiple cardiac proliferative pathways, directly represses cell-cycle inhibitory genes p21, Meis1, and Btg2, promotes adult CM proliferation; and preserves cardiac performance after MI. PMID: 26841808
    4. Tbx20-mediated increases in cell proliferation, providing evidence for parallel regulatory pathways downstream of BMP/Smad1/5/8 signaling in promoting cardiomyocyte proliferation after birth PMID: 23751911
    5. Tbx20 is expressed in the developing endocardial cushions and valves throughout heart development. Ablation of Tbx20 in endocardial cells causes severe valve elongation defects and impaired cardiac function. PMID: 23824573
    6. a dual role for TBX20 as both a transcriptional activator and a repressor, and that each of these functions regulates genes with very specialized and distinct molecular roles PMID: 22328084
    7. Data show distinct functions for Tbx20 in regulation of cardiomyocyte lineage maturation and cell proliferation at embryonic and fetal stages of heart development. PMID: 22226977
    8. Genome-wide ChIP analysis of Tbx20-binding regions in the adult heart revealed that many of these genes were direct downstream targets of Tbx20 and uncovered a previously undescribed DNA-binding site for Tbx20. PMID: 22080862
    9. mice lacking Tbx20 in the atrioventricular canal myocardium fail to form the atrioventricular canal constriction, and the endocardial epithelial-mesenchymal transition (EMT) is severely perturbed. PMID: 21983003
    10. the BMP10-Tbx20 signaling cascade is important for ventricular wall development and maturation. PMID: 21890625
    11. Tbx20 represses Tbx2 in chamber myocardium, preventing repression of Nmyc1 and resulting in relatively high proliferation in the developing heart. PMID: 15843407
    12. Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development. PMID: 15843409
    13. Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation. PMID: 15843414
    14. Study suggests that Tbx20 programs a variety of hindbrain motor neurons for migration, independent of directionality, and in facial neurons is a positive regulator of the non-canonical Wnt signaling pathway. PMID: 17119020
    15. These data highlight unique features of Tbx20 and suggest mechanistic ways in which cardiac T-box factors might interact synergistically and/or competitively within the cardiac regulatory network. PMID: 19414016

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Prominently expressed in the extraembryonic mesoderm, developing heart, eye analage and motor neurons of hindbrain and spinal cord. Expressed in extraembryonic tissues such as the amnion and allantois.
  • 数据库链接：

    KEGG: mmu:57246

    STRING: 10090.ENSMUSP00000052591

    UniGene: Mm.31452