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  4. Recombinant Mouse T-box transcription factor TBX4 (Tbx4)

Recombinant Mouse T-box transcription factor TBX4 (Tbx4)

  • 货号：
    CSB-YP023256MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP023256MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP023256MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP023256MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP023256MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tbx4
  • Uniprot No.：
  • 别名：
    Tbx4; T-box transcription factor TBX4; T-box protein 4
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-552
  • 氨基酸序列
    MLQDKGLSESEEAFRAPGPALGEASNTSTTNAPEPALATPGLSGAALSSPPGQGADVAAA AAAAAEQTIENIKVGLHEKELWKKFHEAGTEMIITKAGRRMFPSYKVKVTGMNPKTKYIL LIDIVPADDHRYKFCDNKWMVAGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTN NHLDPFGHIILNSMHKYQPRLHIVKADENNAFGSKNTAFCTHVFPETSFISVTSYQNHKI TQLKIENNPFAKGFRGSDDSDLRVARLQSKEYPVISKSIMRQRLVSSQLSAKPDVSPLHS AHQALQHYQYENGAHMQFAAAEPQDLPLNTFPTQRDSSLFYHCLKRRDSARHLDLPCKRS YLETPSSVGDDHYFRSPPPYDQQMLSPSYCSEVTPREACMYSSSGPEIAGVSAVDDLPPP PLSCNMWTSVSPYTSYSVQTMETVPYQPFPAHFTATTVMPRLPTIAAQSAQPPGNAHFSV YNQLSQSQVRERGPSASFPRERGLPGMCERKPPSPHLNTANEFLYSQSFSLTRESSLQYH SGMGTVENWTDG
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional regulator that has an essential role in the organogenesis of lungs, pelvis, and hindlimbs.
  • 基因功能参考文献：
    1. TBX4 is a mesenchymal transcription factor that drives accumulation of myofibroblasts and the development of lung fibrosis PMID: 27400124
    2. Although postnatal deletion of Tbx4 in oocytes does not obviously impair fertility, it is possible that the reduction in primordial germ cells observed in Tbx4 homozygous null mutant embryos could affect long-term fertility in adults. PMID: 24089201
    3. Candidate gene approach identifies multiple genes and signaling pathways downstream of Tbx4 in the developing allantois PMID: 22952711
    4. Mice deficient in Tbx4 and Tbx5 show severely reduced lung branching at mid-gestation. PMID: 22876201
    5. Tbx4 expression and lineage reveal that various distinct appendages, such as the allantois, hindlimb, and external genitalia, all arise from a single mesenchymal expression domain. PMID: 21932311
    6. It was shown that, firstly, Pitx1 influences hindlimb outgrowth by regulating Tbx4 expression levels and that, subsequently,Pitx1 shapes hindlimb bone and soft tissue morphology independently of Tbx4. PMID: 22071103
    7. Study find that Tbx4 is the primary effector of HL identity for both skeletal and muscle development. PMID: 20975709
    8. Tbx4 is reported to play a key role in separation of the respiratory tract and the esophagus. PMID: 20182749
    9. Deletion of Tbx4 in hindlimbs specifically affects muscle and tendon patterning without disrupting skeletal development, thus suggesting that distinct cues regulate these processes. PMID: 20152185
    10. show that AmphiTbx4/5 is able to initiate limb outgrowth and, in contrast, that the genomic locus lacks the regulatory modules required for expression that would result in limb formation PMID: 19995988
    11. Tbx4 is not sufficient to determine limb-specific morphologies but have a roles in initiating limb outgrowth. PMID: 15621531
    12. Tbx4 is not required for hindlimb identity or post-bud hindlimb outgrowth. PMID: 17164415
    13. dual hindlimb enhancers provide a flexible genomic mechanism for altering the strength and location of Tbx4 expression during normal development PMID: 18579682

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    KEGG: mmu:21387

    STRING: 10090.ENSMUSP00000000096

    UniGene: Mm.275336