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  4. Recombinant Mouse T-cell acute lymphocytic leukemia protein 1 homolog (Tal1)

Recombinant Mouse T-cell acute lymphocytic leukemia protein 1 homolog (Tal1)

  • 货号：
    CSB-YP023110MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP023110MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP023110MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP023110MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP023110MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tal1
  • Uniprot No.：
  • 别名：
    Tal1; Scl; Tal-1; T-cell acute lymphocytic leukemia protein 1 homolog; TAL-1; Stem cell protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-329
  • 氨基酸序列
    MTERPPSEAA RSDPQLEGQD AAEARMAPPH LVLLNGVAKE TSRAAPAEPP VIELGARSGA GGGPASGGGA ARDLKGRDAV AAEARLRVPT TELCRPPGPA PAPAPASAPA ELPGDGRMVQ LSPPALAAPA GPGRALLYSL SQPLASLGSG FFGEPDAFPM FTNNNRVKRR PSPYEMEISD GPHTKVVRRI FTNSRERWRQ QNVNGAFAEL RKLIPTHPPD KKLSKNEILR LAMKYINFLA KLLNDQEEEG TQRAKPGKDP VVGAGGGGAG GGIPPEDLLQ DVLSPNSSCG SSLDGAASPD SYTEEPTPKH TSRSLHPALL PAADGAGPR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation.
  • 基因功能参考文献：
    1. Tal1 plays an essential role in regulating neurotransmitter phenotype in the developing thalamic nuclei. PMID: 28685891
    2. Genome-wide analysis indicated that LMO2 is required at the hemangioblast stage to position the TAL1/LMO2/LDB1 complex to regulatory elements that are important for the establishment of the hematopoietic developmental program. PMID: 28973433
    3. TAL1 and GATA1 form a precisely organized complex at a compound motif consisting of a TG 7 or 8 bp upstream of a WGATAA motif across thousands of genomic locations PMID: 26503782
    4. SCL-LMO1 upregulated a stem cell gene signature in DN3 thymocytes. PMID: 25522233
    5. TAL1 binds specifically to many genomic locations in multilineage precursor and erythroid progenitor cells, before GATA1 is produced abundantly. PMID: 25319994
    6. Ectopic Runx1 expression rescues Tal-1-deficiency in the generation of primitive and definitive hematopoiesis. PMID: 23922928
    7. Tal1 has a role in severe renal disease and patchy alopecia in Hairpatches (Hpt) mice PMID: 23301070
    8. Only Scl but not Map17 could rescue the Scl(Delta40/Delta40) ES phenotype. PMID: 23319051
    9. Scl overexpression is sufficient to rescue the developmental defects caused by blocking the Hh and Notch pathways during the embryonic endothelial-to-hematopoietic transition. PMID: 23236128
    10. a novel role for GATA-4 and TAL1 to affect skeletal myogenic differentiation and EPO response via cross-talk with Sirt1. PMID: 22773876
    11. Studies revealed an unexpected repressive role for Scl, as loss of Scl resulted in the generation of ectopic cardiomyocytes in yolk sac vasculature and the endocardium; these results uncover remarkable developmental plasticity in embryonic vasculature and identify Scl as a key determinant of endothelial fate choice. PMID: 22863011
    12. Deletion of the Scl +19 enhancer increases the blood stem cell compartment without affecting the formation of mature blood lineages. PMID: 22401818
    13. characterisation of a CTCF-dependent insulator element at the 3' border of the murine Scl transcriptional domain PMID: 22396734
    14. GATA-1, SCL, and Klf1 form an erythroid core transcriptional network by co-occupying >300 genes PMID: 22357756
    15. found that DC-STAMP, a key regulator of osteoclast cell fusion, is a direct target gene of Tal1 and show that Tal1 represses DC-STAMP expression by counteracting the activating function of the transcription factors PU.1 and MITF PMID: 21990371
    16. Data show that thymic expression of the Tal1 and Lmo2 oncogenes results in rapid development of T-ALL, and similar to T-ALL patients, more than half the leukemic mice develop spontaneous mutations in Notch1. PMID: 21670468
    17. SCL-mediated transcriptional control of p21 is essential for terminal maturation of megakaryopoiesis PMID: 21596846
    18. DNA-binding activity of Tal1 is not required to cooperate with Lmo2 to cause leukemia in mice PMID: 21057528
    19. TAL1 coordinates expression of genes in most known red cell-specific processes. Novel motifs were also characterized that may help distinguish activated from repressed genes and suggest a new mechanism by which TAL1 may be recruited to DNA. PMID: 20566737
    20. SCL, LMO1, and Notch1 gain of function, together with an active pre-T-cell antigen receptor, might represent the minimum set of complementing events for the transformation of susceptible thymocytes into cancer cells PMID: 20516195
    21. TAL-1, a basic-helix-loop-helix transcription factor, plays a key role in the formation and functioning of both blood and endothelial systems. Review. PMID: 19527627
    22. The phenotypic and molecular consequences of inactivation of Tal1 expression ex vivo, are characterized. PMID: 20194619
    23. SCL impedes G(0)-G(1) transition in hematopoietic stem cells and regulates their long-term competence PMID: 19850742
    24. distinct lineage-restricted potential of SCL-labelled early progenitors demonstrates that primitive erythroid cell fate specification is initiated during mid gastrulation PMID: 19631738
    25. lethal deletion of phenotype rescued by human SCL locus PMID: 12010791
    26. Results suggest that GATA-2, Fli-1 and Elf-1 are key components of an enhanceosome responsible for activating SCL transcription and establishing the transcriptional programme required for HSC formation. PMID: 12065417
    27. SCL has a role in the differentiation of the GATA population of V2 interneurons PMID: 12112475
    28. Results demonstrate that hematopoietic and endothelial cells develop via distinct, sequential generation of FLK1 and SCL-expressing cells. PMID: 12403720
    29. SCL/Tal1 has a role in determining hematopoietic lineage as part of endothelial differentiation PMID: 12485991
    30. SCL/tal-1 is essential for the genesis of hematopoietic stem cells (HSCs), but its continued expression is not essential for HSC functions PMID: 12540851
    31. SCL is critical for megakaryopoiesis and erythropoiesis, but is dispensable for production of myeloid cells during adult hematopoiesis PMID: 12552125
    32. the dosage of SCL determines pT alpha gene expression in immature T cells PMID: 12566462
    33. Data show that a nuclear complex containing TAL1 and LIM domain-binding protein Ldb1 transactivates the protein 4.2 (P4.2) gene. PMID: 14560005
    34. Given the presence of SCL in both the developing brain and in post-mitotic neurons, it seems likely that the function of SCL in neuronal differentiation may differ from its function in maintaining the differentiated state of the mature neuron. PMID: 14614907
    35. demonstrated a severe multilineage defect in repopulation capacity by SCL-deleted bone marrow cells; transplantation defect of SCL-deleted cells was observed within 4 weeks, indicating a defect in a multipotent progenitor or short-term repopulating HSCs PMID: 14726374
    36. the up-regulation or down-regulation of SCL directs hematopoietic stem cells toward myeloid or lymphoid lineage, respectively, although SCL does not affect their long-term repopulating capacity. PMID: 14726394
    37. SCL is a nucleation factor within a higher-order complex required to activate glycophorin A expression PMID: 14749362
    38. Data demonstrate that two geographically distinct but functionally related enhancers regulate scl(tal-1) transcription in hematopoietic progenitors and endothelial cells. PMID: 14966269
    39. tal1/scl induces leukemia by repressing E47/HEB PMID: 15193261
    40. Results identify residues in the helix-loop-helix (HLH) domain of SCL/Tal-1 that are critical for hematopoietic specification. PMID: 15314159
    41. SCL-dependent phase of hematopoietic stem cells development ends before Tie2Cre-mediated gene ablation becomes effective PMID: 15677556
    42. Scl-/- endothelial cells display a growth deficiency in monolayer cultures PMID: 15677567
    43. Results show striking coexpression of SCL and its immediate downstream neighbor, MAP17, suggesting that they share regulatory elements. PMID: 15923636
    44. SCL-independent erythropoiesis can proceed in the adult PMID: 16024775
    45. association with SCL, core-binding factor, runt domain, alpha subunit 2 represses gene expression in the early stages of erythroid differentiation PMID: 16287841
    46. multiple functions of Stem cell leukaemia in the regulation of both astrocyte versus oligodendrocyte cell fate acquisition and V2b versus V2a interneuron cell fate acquisition in the p2 domain of the developing vertebrate spinal cord PMID: 16292311
    47. Loss of either p16(ink4a) or p19(arf) cooperates with Tal1 to induce leukemia in mice. Tal1 stimulates cell cycle entry independent of the ink4a/arf locus, but its ability to induce apoptosis is Ink4a/Arf-dependent. PMID: 16407836
    48. SCL +19 enhancer targets a mesodermal progenitor capable of generating hematopoietic, vascular, and osteoblastic progeny. PMID: 16537906
    49. A crucial role for Scl in the development of Scl-expressing neurons, including gamma-aminobutyric acid (GABA)ergic interneurons is demonstrated. PMID: 16623824
    50. Expression of selected transgenes in myeloid, megakaryocytic, erythroid, and c-kit-expressing lineage-negative bone marrow cells can be directed through SCL regulatory elements. PMID: 16675709

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Erythroid and myeloid cells.
  • 数据库链接：

    KEGG: mmu:21349

    STRING: 10090.ENSMUSP00000030489

    UniGene: Mm.239869