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  4. Recombinant Mouse T-cell immunoglobulin and mucin domain-containing protein 2 (Timd2), partial

Recombinant Mouse T-cell immunoglobulin and mucin domain-containing protein 2 (Timd2), partial

  • 中文名称：
    小鼠Timd2重组蛋白
  • 货号：
    CSB-YP840265MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Timd2重组蛋白
  • 货号：
    CSB-EP840265MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Timd2重组蛋白
  • 货号：
    CSB-EP840265MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Timd2重组蛋白
  • 货号：
    CSB-BP840265MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Timd2重组蛋白
  • 货号：
    CSB-MP840265MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Timd2
  • Uniprot No.：
  • 别名：
    Timd2; Tim2; T-cell immunoglobulin and mucin domain-containing protein 2; TIMD-2; T-cell immunoglobulin mucin receptor 2; TIM-2; T-cell membrane protein 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Probable receptor for SEMA4A involved in the regulation of T-cell function. The interaction with SEMA4A enhances T-cell activation.
  • 基因功能参考文献：
    1. We concluded that pro-apoptotic effects on Th1 population through galectin-9-Tim-3 pathway and the up-regulation of Tim-2 on Th2 cells might be critical to Th2-biased response of host with schistosomiasis japonica. PMID: 22469568
    2. TIM-2 signaling influences both proliferation and antibody production of B cells during the early phase of collagen-induced arthritis PMID: 21426565
    3. TIM-2 can function as an iron uptake pathway. PMID: 21886823
    4. The increased expression of the pro-inflammatory and proapoptotic genes, a higher number of apoptotic cells, and increased injury and mortality of the TIM2-deficient mice suggest a protective role of TIM2 in cisplatin-induced nephrotoxicity. PMID: 20702592
    5. TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis. PMID: 16203866
    6. expression of TIM-2 significantly impairs the induction of NFAT and AP-1 transcriptional reporters PMID: 17015678
    7. The mTIM-1 structure identified a homophilic TIM-TIM adhesion interaction, whereas the mTIM-2 domain formed a dimer that prevented homophilic binding. PMID: 17363299
    8. There are Tim2-binding molecules on hepatocytes. Tim2-hFc inhibited differentiation & proliferation of hepatocytes in fetal liver primary culture. Down-regulation of Tim2 expression by siRNA enhanced expression of liver differentiation marker genes. PMID: 17465005
    9. Tim-2 negatively regulates the Th2 differentiation of Ag-primed T-cells and the development of EC during the effector phase. PMID: 17532058

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Immunoglobulin superfamily, TIM family
  • 数据库链接：

    KEGG: mmu:171284

    STRING: 10090.ENSMUSP00000060891

    UniGene: Mm.234654