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  4. Recombinant Mouse TBC1 domain family member 15 (Tbc1d15)

Recombinant Mouse TBC1 domain family member 15 (Tbc1d15)

  • 中文名称：
    小鼠Tbc1d15重组蛋白
  • 货号：
    CSB-YP863458MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Tbc1d15重组蛋白
  • 货号：
    CSB-EP863458MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Tbc1d15重组蛋白
  • 货号：
    CSB-EP863458MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Tbc1d15重组蛋白
  • 货号：
    CSB-BP863458MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Tbc1d15重组蛋白
  • 货号：
    CSB-MP863458MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Tbc1d15; TBC1 domain family member 15; GTPase-activating protein RAB7; GAP for RAB7; Rab7-GAP
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-671
  • 氨基酸序列
    AAAGVVSGK IIYEQEGVYI HSSCGKANDQ DSLISGILRV LEKDAEVIVD WRPLDDALDS SSILCAGKDS SSVVEWTQAP KERAHRGSDQ QSSYEAEWDM VTTVSFKKKP HTNGDAPGHR NGKSKWSFLF SLADLKSVKQ SKEGMGWSYL VFCLKDDVML PALHFHQGDS KLLIESLEKY VVLCESPQDS RTLLVNCQNK SLSQSFENLL DEPAYGLIQK IKKDPYTATM VGFSKVTNYI FDSLRGSDPS THQRPPSEMA DFLSDAIPGL KINQQEEPGF EVITRIDLGE RPVVQRREPV SLEEWNKSLD PEGRLVAVES MKQKIFRGGL SHSLRKQAWK FLLGYFPWDS TKEERTQLQK QKTDEYFRMK LQWKSVSEAQ EKRNSRLRDY RSLIEKDVNR TDRTNKFYEG QDNPGLILLH DILMTYCMYD FDLGYVQGMS DLLSPLLYVM ENEVDAFWCF ASYMDQMHQN FEEQMQGMKT QLIQLSTLLR LLDSGFCSYL ESQDSGYLYF CFRWLLIRFK REFSFLDILR LWEVMWTELP CKNFHLLLCC AILESEKQQI MAKHYGFNEI LKHINELSMK IDVEDILCKA EAISLQMAQC KELPQAVCEI LGLQDSEITT PDSDTDENVG SPCPVSAFPS STLPILAASE AKDDSPTQTL ASPNACRLTP A
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6.
  • 基因功能参考文献：
    1. nigericin-induced mitochondria fission was rescued by knockdown of either dynamin-related protein 1 or TBC1 domain family member 15 (TBC1D15), which are two distinct mitochondria fission regulators, only TBC1D15 restored the activity of the STING pathway, which indicates that inflammasome-activating signals curtail STING pathway activation via TBC1D15. PMID: 28729291
    2. although only TBC1D15/Rab7-GAP altered Rab7-GTP levels, both Rab7-GAP and mVps39 regulate lysosomal morphology and play a role in maintaining growth factor dependence PMID: 20363736
    3. TBC1D15 may be involved in Rab7-mediated late endosomal trafficking PMID: 16055087
  • 亚细胞定位：
    Cytoplasm.
  • 组织特异性：
    Ubiquitous, with highest expression in heart, liver and testis and lower expression in brain, spleen, lung, kidney and skeletal muscle.
  • 数据库链接：

    KEGG: mmu:66687

    STRING: 10090.ENSMUSP00000020339

    UniGene: Mm.22252