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  4. Recombinant Mouse TRAF-interacting protein with FHA domain-containing protein A (Tifa)

Recombinant Mouse TRAF-interacting protein with FHA domain-containing protein A (Tifa)

  • 中文名称：
    小鼠Tifa重组蛋白
  • 货号：
    CSB-YP762365MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Tifa重组蛋白
  • 货号：
    CSB-EP762365MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Tifa重组蛋白
  • 货号：
    CSB-EP762365MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Tifa重组蛋白
  • 货号：
    CSB-BP762365MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Tifa重组蛋白
  • 货号：
    CSB-MP762365MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tifa
  • Uniprot No.：
  • 别名：
    Tifa; T2bp; TRAF-interacting protein with FHA domain-containing protein A; TRAF2-binding protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-184
  • 氨基酸序列
    MSTFEDADTE ETVTCLQMTI YHPGQQSGIF KSIRFCSKEK FPSIEVVKFG RNSNMCQYTF QDKQVSRIQF VLQPFKQFNS SVLSFEIKNM SKKTSLMVDN QELGYLNKMD LPYKCMLRFG EYQFLLQKED GESVESFETQ FIMSSRPLLQ ENNWPTQNPI PEDGMYSSYF THRSSPSEMD ENEL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Adapter molecule that plays a key role in the activation of proinflammatory NF-kappa-B signaling following detection of bacterial pathogen-associated molecular pattern metabolites (PAMPs). Promotes activation of an innate immune response by inducing the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism. TIFA-dependent innate immune response is triggered by ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria: ADP-Heptose is recognized by ALPK1, which phosphorylates TIFA at Thr-9, leading to TIFA homooligomerization and subsequent activation of proinflammatory NF-kappa-B signaling.
  • 基因功能参考文献：
    1. The increase in TIFA level appears to be a feed-forward mechanism involved in TLR4/MyD88-dependent signaling, leading to NF-kappaB activation and HMGB1 release PMID: 23722163
    2. TIFA is likely to mediate IRAK-1/TRAF6 interaction upon IL-1 stimulation PMID: 12566447
    3. We propose that ZCCHC11 is a unique TLR signal regulator, which interacts with TIFA after LPS treatment and suppresses the TRAF6-dependent activation of NF-kappaB. PMID: 16643855
  • 亚细胞定位：
    Cytoplasm.
  • 组织特异性：
    Highly expressed in the spleen and at lower levels in heart, brain, lung, liver, kidney and testes.
  • 数据库链接：

    KEGG: mmu:211550

    STRING: 10090.ENSMUSP00000054036

    UniGene: Mm.31852