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  4. Recombinant Mouse Tachykinin-4 (Tac4)

Recombinant Mouse Tachykinin-4 (Tac4)

  • 中文名称：
    小鼠Tac4重组蛋白
  • 货号：
    CSB-YP858775MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Tac4重组蛋白
  • 货号：
    CSB-EP858775MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Tac4重组蛋白
  • 货号：
    CSB-EP858775MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Tac4重组蛋白
  • 货号：
    CSB-BP858775MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Tac4重组蛋白
  • 货号：
    CSB-MP858775MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tac4
  • Uniprot No.：
  • 别名：
    Tac4; Tachykinin-4; Preprotachykinin-C; PPT-C) [Cleaved into: Hemokinin; HK1; Hemokinin-1; Hemokinin-I; HK-I)]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Cytoplasmic domain
  • 表达区域：
    56-66
  • 氨基酸序列
    RSRTR QFYGLM
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Hemokinin induces plasma extravasation, mast cell degranulation, muscle contraction, salivary secretion and scratching behavior. Increases sperm motility. Induces potent analgesic effects and may play a role in pain modulation. Promotes survival of bone marrow B lineage cells and of cultured LPS-stimulated pre-B cells and may act as an autocrine factor required for B-cell survival and proliferation. Lowers systemic arterial pressure following intravenous injection. Induces interferon-gamma production and may play a role in the inflammatory response. Shows potent affinity and specificity for the NK-1 receptor.
  • 基因功能参考文献：
    1. Our results provide the first evidence for an anxiolytic and anti-depressant-like actions of HK-1 through a presently unknown target-mediated mechanism PMID: 27621226
    2. hemokinin-1 plays a crucial pro-inflammatory role in the lung by increasing inflammatory cell activities, and might also be a specific regulator of lymphocyte functions. PMID: 25541043
    3. Hemokinin-1, but not substance P increases inflammation and hyperalgesia in the late phase of adjuvant-induced arthritis. PMID: 23626716
    4. These findings suggest that tachykinins and NK1 receptors play a key role in joint inflammation, rather than in nociceptive sensitization, in collagen antibody-induced arthritis A. PMID: 22687356
    5. HKs emerge as pivotal endogenous regulators of angiogenesis through neurokinin-1 receptor PMID: 22554585
    6. Our findings suggest a role for TAC4 in cell differentiation, and represent a regulatory bridge between the nervous system and the immune system. PMID: 20965576
    7. cultures from TAC4(-/-) bone marrow, sorted "fraction B" pro-B cells or purified long-term reconstituting stem cells, contain higher numbers of pro-B cells compared with controls, suggesting an inhibitory role for HK-1 on developing B cells PMID: 20660792
    8. Preprotachykinin (PPT)-C genes are expressed in uterine cells, oocytes, ovaries and embryos from mice, and may play a role in female reproductive function. PMID: 12773411
    9. HK-1 influences T-cell development, enhancing the proliferation of T-cell precursors and increased the number of thymocytes in fetal thymus organ cultures PMID: 12791665
    10. HK and SP are expressed at sites of chronic inflammation and share cell origin, receptor, and immunoregulatory function. PMID: 15153465
    11. Here we demonstrate the expression of mouse PPT-C (hemokinin 1 precursor) mRNA by CD11b+ macrophages, CD11c+ dendritic cells and in the microglial cell line EOC 13.31. PMID: 15342200
    12. B cell lysates routinely demonstrated a low or undetectable immunoreactive peptide. PMID: 16360135
    13. mouse hemokinin 1 and mouse hemokinin 1(2-11) are tachykinin NK(1) receptor-preferring uterotonic agonists in non-pregnant mice but lack action at the myometrial tachykinin NK(2) receptors present in late pregnant mice PMID: 18977217
    14. Results suggest that Hemokinin-1 is regulated by a unique transcription regulation system that likely governs its differential expression pattern and suggests a role for Hemokinin-1 distinct from Substance P. PMID: 19081134

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Tachykinin family
  • 组织特异性：
    Expressed in hematopoietic cells with highest levels in pre- and pro-B cells but not in later developmental stages. Also detected in uterus, skeletal muscle, brain, spleen, stomach, skin and lactating mammary gland and in cells of myeloid lineage includin
  • 数据库链接：

    KEGG: mmu:93670

    STRING: 10090.ENSMUSP00000021242

    UniGene: Mm.40085