Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Mouse Thioredoxin domain-containing protein 5 (Txndc5)

Recombinant Mouse Thioredoxin domain-containing protein 5 (Txndc5)

  • 货号：
    CSB-YP835570MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP835570MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP835570MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP835570MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP835570MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Txndc5; Tlp46; Thioredoxin domain-containing protein 5; Endoplasmic reticulum resident protein 46; ER protein 46; ERp46; Plasma cell-specific thioredoxin-related protein; PC-TRP; Thioredoxin-like protein p46
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    34-417
  • 氨基酸序列
    QEVEADS GVEQDPHAKH LYTADMFTHG IQSAAHFVMF FAPWCGHCQR LQPTWNDLGD KYNSMEDAKV YVAKVDCTAD SDVCSAQGVR GYPTLKFFKP GQEAVKYQGP RDFETLENWM LQTLNEEPAT PEPEAEPPRA PELKQGLYEL SANNFELHVS QGNHFIKFFA PWCGHCKALA PTWEQLALGL EHSETVKIGK VDCTQHYAVC SEHQVRGYPT LLWFRDGKKV DQYKGKRDLE SLRDYVQSQL QGSEAAPETV EPSEAPVMAA EPTGDKGTVL ALTEKSFEDT IAQGITFVKF YAPWCGHCKN LAPTWEELSK KEFPGLSDVT IAEVDCTAER NVCSKYSVRG YPTLLLFRGG EKVGEHNGGR DLDSLHSFVL RQAKDEL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast.
  • 基因功能参考文献：
    1. Hypoxia induced TXCNDC5 expression, which contributed to adiponectin expression, cytokine production and the cellular proliferation and migration of fibroblasts in rheumatoid arthritis. PMID: 23326410
    2. Txndc5 reflects the anti-steatotic properties of squalene and the sensitivity to lipid accumulation. PMID: 22796066
    3. ERp46 plays a protective role in palmitic acid -induced cell apoptosis by decreasing the endoplasmic reticulum stress response and might be a novel target for anti-diabetic drugs. PMID: 22935416
    4. Potential role for TXNDC5 in resistance to nitrosative stress. PMID: 20550962
    5. both ERp19 and ERp46 and their respective mRNAs are highly expressed in the liver as compared with other tissues PMID: 12930873
    6. PC-TRP was expressed at high levels in all plasma cells isolated from bone marrow or lamina propria. PMID: 14971039
    7. ERp46 may be an important component in the phenomenon of "glucose toxicity" involved in insulin production at the posttranslational level. PMID: 19622788

    显示更多

    收起更多

  • 亚细胞定位：
    Endoplasmic reticulum lumen.
  • 蛋白家族：
    Protein disulfide isomerase family
  • 组织特异性：
    Expressed at high levels in plasma cells and at very low levels in all other cells and tissues examined (at protein level).
  • 数据库链接：

    KEGG: mmu:105245

    STRING: 10090.ENSMUSP00000041839

    UniGene: Mm.28622