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  4. Recombinant Mouse Thymic stromal lymphopoietin (Tslp)

Recombinant Mouse Thymic stromal lymphopoietin (Tslp)

  • 货号：
    CSB-YP025141MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP025141MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP025141MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP025141MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP025141MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Tslp; Thymic stromal lymphopoietin; Thymic stroma-derived lymphopoietin
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    20-140
  • 氨基酸序列
    Y NFSNCNFTSI TKIYCNIIFH DLTGDLKGAK FEQIEDCESK PACLLKIEYY TLNPIPGCPS LPDKTFARRT REALNDHCPG YPETERNDGT QEMAQEVQNI CLNQTSQILR LWYSFMQSPE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.
  • 基因功能参考文献：
    1. this paper shows that IL-33 promotes gastrointestinal allergy in a TSLP-independent manner PMID: 28656964
    2. a new pathway for the activation of Treg involving in tumor-derived HMGB1 and TSLP, and have important implications for incorporating HMGB1 inhibitors into cancer immunotherapy. PMID: 29116372
    3. Effects of Linalyl Acetate on Thymic Stromal Lymphopoietin Production in Mast Cells. PMID: 30011850
    4. findings suggest a role of TSLP in directly promoting Th2 cell effector function and support the notion of TSLP as a key driver of Th2 PMID: 29339496
    5. Thymic stromal lymphopoietin and IL-33 promote skin inflammation and vaccinia virus replication in a mouse model of atopic dermatitis. PMID: 26830114
    6. the pathological mechanisms of particulate matter PM2.5 may be associated with allergic/steroidresistant airway inflammation, Tcell helper (Th)1/Th2 cytokine production and upregulation of TSLP expression in a murine model of allergic and steroid-resistant asthma. PMID: 28765890
    7. Results suggest combinatorial mechanisms involved in the tissue-selective regulation of thymic stromal lymphopoietin (TSLP) transcription in epidermal keratinocytes and intestinal epithelial cell(s) (IEC). PMID: 28115699
    8. these results suggest that TSLP-TSLPR signaling is pivotal in the induction of nasal respiratory immunity against pathogenic pneumococcal infection PMID: 27924821
    9. blockading the JAK/STAT pathway restrains inflammatory Th2 cell response induced by TSLP-DCs in allergic rhinitis. PMID: 28214951
    10. study concludes that IL-33 and TSLP are required for epithelial cell IL-25 expression, mucous metaplasia, and ILC2 expansion following early-life rhinovirus infection PMID: 28701507
    11. TSLP plays a role in dysfunction of airway epithelial adherens junctions E-cadherin in house dust mite (HDM)-induced asthma. Mice treated with an anti-TSLP mAb ameliorated airway inflammation, the decreasing and aberrant distribution of E-cadherin and beta-catenin as well as phosphorylation(p)-AKT induced by HDM. In vitro, HDM increased the expression of TSLP and E-cadherin dysfunction by PI3K/Akt signaling pathway. PMID: 28400057
    12. this study shows that TSLP is a key target of Mi-2beta in keratinocytes, and that loss of TSLP signaling in regulatory T cells prevents their activation PMID: 28092372
    13. These data demonstrate that multiple pathogenic strains of RSV induce IL-13-producing group 2 innate lymphoid cell proliferation and activation through a TSLP-dependent mechanism in a murine model and suggest the potential therapeutic targeting of TSLP during severe RSV infection. PMID: 27156176
    14. the effects of TSLP on myeloid cells are crucial in reducing the multiple organ failure that is associated with systemic inflammation. PMID: 26934097
    15. The inflammatory phenotype in barrier-defective skin is shaped by counterregulation between the TSLP/type 2 and IL-23/type 17 axes. PMID: 26993035
    16. this study shows that activation of primed TH2 cells occurs independently of group 2 innate lymphoid cells or their cytokines but that the effector function of both cell types was dependent on combinatorial exposure to IL-33, IL-25 and TSLP PMID: 27749840
    17. TNF-alpha and IL-1beta, which are partly produced by LPS-activated leukocytes, contribute to TSLP production via TLR4 activation in vivo. PMID: 27271511
    18. IL-33-ERK/JNK/p38/Egr-1/TSLP axis involved in allergic skin Th2 inflammation PMID: 26120956
    19. Suggest that TSLP may be involved in acute lung injury, and blockage of TSLP signaling using TSLPR-Ig improves ALI at least in part by regulation of dendritic cell functions. PMID: 26617780
    20. TSLP expression in the skin is mediated via RARgamma-RXR pathways. PMID: 26531761
    21. results highlight a previously unappreciated function of the immune system in controlling the early development of cancer and establish a fundamental role for TSLP and Th2 cells in tumor immunity against early-stage cancers. PMID: 26927668
    22. Thymic stromal lymphopoietin-induced interleukin-17A is involved in the development of IgE-mediated atopic dermatitis-like skin lesions in mice PMID: 26310839
    23. production by monocyte-derived dendritic cells requires the integration of signals from dectin-1, the IL-1 receptor, and endoplasmic reticulum stress response stress signaling pathways PMID: 26573878
    24. The short TSLP isoform ameliorates experimental colitis in mice and prevents endotoxin shock. The long TSLP isoform is proinflammatory and is only expressed during inflammation. PMID: 26014813
    25. Suggest that Treg defects in ApoE(-/-) mice might partially be attributed to the disruption of TSLP-TSLPR-LAP signaling in epithelial cells and dendritic cells. PMID: 25544178
    26. expression of, and immune activation by, TSLP contributes significantly to the immunopathology of experimental autoimmune encephalomyelitis. PMID: 25753260
    27. These results demonstrate a role for TSLP and IL-25 in the atopic march from skin sensitization to food allergic responses and provide a model system for the generation of potential therapeutic interventions PMID: 25365222
    28. basophils and TSLP have pivotal roles in Th2 development in the skin during the sensitization phase of food allergy. PMID: 24860117
    29. Thymic stromal lymphopoietin plays divergent roles in the pathogenesis of atopic and nonatopic asthma phenotypes by either enhancing Th2 responses or curtailing T-helper 17 responses. PMID: 24961817
    30. TSLP signaling in CD41 T cells is required for not only TH2 memory cell formation in vivo but also the recall response of the memory cells to local antigen challenge. PMID: 25441291
    31. constitutively expressed by hepatocytes and increased during halothane-induced liver injury PMID: 24723460
    32. TN DC represent a dermal DC subset that should be considered in future studies of TSLP-dependent contact sensitization and skin immune responses. PMID: 25057004
    33. Report glyphosphate-rich air samples stimulate airway inflammation via IL-33/TSLP/IL-13 pathways. PMID: 25172162
    34. TSLP levels peak early but are sustained during the first 48 h of sepsis. PMID: 24990542
    35. chronic exposure to natural airborne allergens triggers a network of innate and adaptive type 2 immune responses and airway pathology, and IL-33 and thymic stromal lymphopoietin most likely play key roles in this process. PMID: 25015831
    36. Skin Tslp initiates Th2 responses through an orchestrated immune cascade. PMID: 24284909
    37. plays an important role as a master switch of allergic inflammation because it promotes Th2-type immune responses by inducing the activation of dendritic cells. PMID: 24599138
    38. Increased density of intraepithelial mast cells in patients with exercise-induced bronchoconstriction regulated through epithelially derived thymic stromal lymphopoietin and IL-33. PMID: 24220317
    39. Epicutaneous sensitization on a disrupted skin barrier is associated with accumulation of TSLP-elicited basophils, which are necessary and sufficient to promote antigen-induced intestinal food allergy. PMID: 24560412
    40. promotes mutualistic T-cell responses following intestinal bacterial colonization PMID: 23515135
    41. RG1 has the inhibitory effect of TSLP production and caspase-1 activity in AR experimental model. PMID: 24053327
    42. The structure of the mouse TSLP-mediated signaling complex reveals how TSLP establishes extensive interfaces with its cognate receptor (TSLPR). PMID: 24632570
    43. These results suggest that Nickel allergy may be triggered by a TSLP/TSLPR-mediated interaction between epithelial and immune cells PMID: 24670797
    44. TSLP stimulation can induce cellular senescence during airway remodeling in asthma. Inhibiting the signaling pathways of cellular senescence overcomes TSLP-induced airway remodeling PMID: 24167583
    45. These results indicate that the progesterone suppresses Th17 cell responses, and enhances the development of Treg cells, through TSLP-dependent mechanisms, and play a role in female asymptomatic gonococcal infections. PMID: 23835188
    46. these data suggest that TSLP uniquely participates in local immunity in the respiratory tract and modulation of TSLP levels may promote long-term CD8 T cell immunity in the mucosa when other prosurvival signals are limiting. PMID: 24489089
    47. Report mouse cell line producing high levels of TSLP which can be used in high-throughput screening for anti-allergy agents. PMID: 24252242
    48. TSLP expression is enhanced by the absence of microbiota in mice with defective skin barriers PMID: 23698100
    49. Findings show that keratinocyte-derived TSLP activates sensory neurons directly to evoke itch behaviors. PMID: 24094650
    50. TSLP expression in CCR2-/- mice may contribute to the propensity of these mice to develop exaggerated Th2-type immune responses PMID: 23472158

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  • 亚细胞定位：
    Secreted.
  • 数据库链接：

    KEGG: mmu:53603

    STRING: 10090.ENSMUSP00000025237

    UniGene: Mm.143716