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  4. Recombinant Mouse Thymidine phosphorylase (Tymp)

Recombinant Mouse Thymidine phosphorylase (Tymp)

  • 货号：
    CSB-YP025392MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP025392MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP025392MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP025392MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP025392MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tymp
  • Uniprot No.：
  • 别名：
    Tymp; Ecgf1; Thymidine phosphorylase; TP; EC 2.4.2.4; TdRPase
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-471
  • 氨基酸序列
    MAAPGTPPPS ASGGGGGEPR QLPELIRLKR DGGHLREADI RNFVHAVIDG RAQDTQIGAM LMAIRLQGMN LEETSVLTRA LAESGQQLEW PKAWHQQLVD KHSTGGVGDK VSLVLAPALA ACGCKVPMIS GRSLGHTGGT LDKLESIPGF GVTQSPEQML HILEEVGCCI VGQSAKLVPA DGILYAARDV TATVDSVPLI TASILSKKAV EGLSTLVVDV KFGGAAVFPD QEKARELAKM LVRVGVSLGL KVAAALTAMD NPLGRSVGHT LEVEEALLCL DGAGPPDLRD LVIRLGGAIL WISGQAETQD QGAARVAAAL DDGSARRRFQ LMLSAQGVDP GLAKALCSGS PTQRRQLLPH AREQEELLAP ADGIVECVRA LPLARVLHDL GAGRSRAGQP IRPGVGAEVL VDVGQCLSRG TPWLRVHLDG PALSSQQRRT LQGALVLSDR APFKVPSPFA ELVLPPTIAQ P
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
  • 基因功能参考文献：
    1. data identify TYMP as an astrocyte-derived permeability factor, and suggest TYMP and VEGFA together promote blood-brain barrier breakdown. PMID: 25805644
    2. TYMP participates in multiple platelet signaling pathways and regulates platelet activation and thrombosis. Targeting TYMP might be a novel antiplatelet and antithrombosis therapy. PMID: 25287063
    3. The PyNpase levels in mouse bladder tissue were significantly higher in BBN-treatment bladder cancer groups than in those in the control group PMID: 17681069
    4. Thymidine phosphorylase and UPP1 double knockout mice showed increased thymidine and deoxyuridine in tissues and developed encephalopathy. PMID: 19028666
  • 蛋白家族：
    Thymidine/pyrimidine-nucleoside phosphorylase family
  • 数据库链接：

    KEGG: mmu:72962

    STRING: 10090.ENSMUSP00000023285

    UniGene: Mm.287977