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  4. Recombinant Mouse Tissue factor pathway inhibitor 2 (Tfpi2)

Recombinant Mouse Tissue factor pathway inhibitor 2 (Tfpi2)

  • 货号：
    CSB-YP023438MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP023438MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP023438MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP023438MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP023438MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tfpi2
  • Uniprot No.：
  • 别名：
    Tfpi2; Tissue factor pathway inhibitor 2; TFPI-2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    23-230
  • 氨基酸序列
    LTSVSAQG NNLEICLLPL DAGPCQALIP KFYYDRDQQK CRRFNYGGCL GNANNFHSRD LCQQTCGSIE KVPPVCRSEL KTYPCDKPNI RFFFNLNTMT CEPLRPGLCS RTINVFSEEA TCKGLCEPRK HIPSFCSSPK DEGLCSANVT RFYFNSRNKT CETFTYTGCG GNENNFYYLD ACHRACVKGW KKPKRWKIGD FLPRFWKHLS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin.
  • 基因功能参考文献：
    1. Tissue factor pathway Inhibitor 2 potencies differ between antifibrinolytic agents against human and mouse enzymes plasmin, factor XIa, and kallikrein PMID: 27797450
    2. A novel mouse model is presented and can be used to investigate the role of TFPI-2 in the process of atherosclerosis. PMID: 26603320
    3. Over-expression of TFPI-2 promotes atherosclerotic plaque stability, which may be related to inhibition of matrix metalloproteinases. PMID: 23608390
    4. Bovine TFPI2 was compared to mouse TFPI2. PMID: 12921785
    5. human and murine TFPI-2 have different functions in liver regulation during inflammation in the two species PMID: 14983234
    6. Our data suggest that TFPI-2 may be an important regulator of aberrant angiogenesis associated with tumor growth/metastasis, cardiovascular diseases, chronic inflammation, or diabetes. PMID: 17138934
    7. Deficiency for the histone methyltransferase EHMT2 or for the Polycomb group protein EED, leads to biallelic expression of Tfpi2 in the extra-embryonic lineages, whereas the other genes in the cluster maintain correct imprinting. PMID: 18480470
    8. Dynamic changes of Tfpi2 associated with Il-1beta and Tnf-alpha in the development of acute lung injury are reported. PMID: 18499235

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  • 亚细胞定位：
    Secreted.
  • 组织特异性：
    Highly expressed in placenta. Also expressed in liver and kidney.
  • 数据库链接：

    KEGG: mmu:21789

    STRING: 10090.ENSMUSP00000031674

    UniGene: Mm.25612