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  4. Recombinant Mouse Toll-interacting protein (Tollip)

Recombinant Mouse Toll-interacting protein (Tollip)

  • 货号：
    CSB-YP886395MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP886395MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP886395MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP886395MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP886395MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Tollip; Toll-interacting protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-274
  • 氨基酸序列
    ATTVSTQRG PVYIGELPQD FLRITPTQQQ QQIQLDAQAA QQLQYGGTVG TVGRLSITVV QAKLAKNYGM TRMDPYCRLR LGYAVYETPT AHNGAKNPRW NKVIQCTVPP GVDSFYLEIF DERAFSMDDR IAWTHITIPE SLKQGQVEDE WYSLSGRQGD DKEGMINLVM SYTSLPAAMM MPPQPVVLMP TVYQQGVGYV PIAGMPAVCS PGMVPMAMPP PAVAPQPRCN EEDLKAIQDM FPNMDREVIR SVLEAQRGNK DAAINSLLQM GEES
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates.
  • 基因功能参考文献：
    1. Tollip-deficiency may accelerate neuron death related to neurological disease such as Alzheimer's disease PMID: 27720815
    2. Green Tea Polyphenol EGCG Upregulates Tollip Expression by Suppressing Elf-1 Expression PMID: 28954885
    3. Tollip deficiency selectively leads to enlarged yet stable atherosclerotic plaques, increased circulating lipids, liver steatosis, and reduced inflammation. Compromised lipophagy and reduced expression of inflammatory mediators due to Tollip deficiency may be the underlying causes. PMID: 28396568
    4. This study demonstrated that a critical role of Tollip in the early phase of TLR4-mediated neuroinflammation. PMID: 27927222
    5. Tollip acts as a novel modulator of I/R injury by promoting neuronal apoptosis and ischaemic inflammation, which are largely mediated by suppression of Akt signalling. PMID: 26011492
    6. TOLLIP contributes to mortality following myocardial infarction through promoting inflammation and apoptosis PMID: 25765712
    7. Data show that histone lysine methyltransferase Ezh1 promotes toll-like receptor (TLR)-triggered inflammatory cytokine production by suppressing the Toll-interacting protein (Tollip), contributing to full activation of the innate immunity. PMID: 25687760
    8. Overall, our data show an essential role for Tollip on colitis susceptibility in mice. PMID: 24572204
    9. negative regulator of pathological cardiac hypertrophy by blocking the AKT signalling pathway PMID: 24285748
    10. Tollip cooperates with Smad7 to modulate intracellular trafficking and degradation of ubiquitinated TbetaRI, whereby negatively regulates TGF-beta signaling pathway. PMID: 23027871
    11. DNA and protein coimmunization induces regulatory dendritic cells through caveolin-1- and Tollip-mediated negative signaling. PMID: 22904311
    12. Low-dose lipopolysaccharide utilizes Tollip and interleukin (IL)-1 receptor-associated kinase (IRAK)-1 to induce mitochondrial reactive oxygen species to subsequently induce activating transcription factor (ATF)2 in chronic low-grade inflammatory disease. PMID: 22706082
    13. Tollip is a critical mediator responsible for the anti-inflammatory action of epigallocatechin-3-gallate in activated macrophages. PMID: 20511545
    14. Tollip controls the magnitude of inflammatory cytokine production in response to IL-1beta and LPS. PMID: 16428431

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Tollip family
  • 组织特异性：
    Detected in heart, brain, spleen, lung, liver, skeletal muscle, kidney, thymus, pancreas and testis.
  • 数据库链接：

    STRING: 10090.ENSMUSP00000001950

    UniGene: Mm.103551