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  4. Recombinant Mouse Transcription factor CP2-like protein 1 (Tcfcp2l1)

Recombinant Mouse Transcription factor CP2-like protein 1 (Tcfcp2l1)

  • 中文名称：
    小鼠Tfcp2l1重组蛋白
  • 货号：
    CSB-YP667584MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Tfcp2l1重组蛋白
  • 货号：
    CSB-EP667584MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Tfcp2l1重组蛋白
  • 货号：
    CSB-EP667584MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Tfcp2l1重组蛋白
  • 货号：
    CSB-BP667584MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Tfcp2l1重组蛋白
  • 货号：
    CSB-MP667584MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tfcp2l1
  • Uniprot No.：
  • 别名：
    Tfcp2l1; Crtr1; Tcfcp2l1; Transcription factor CP2-like protein 1; CP2-related transcriptional repressor 1; CRTR-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-479
  • 氨基酸序列
    MLFWHTQPEH YNQHNSGSYL RDVLALPIFK QEEPQLSPEN GARLPPLQYV LCAATSPAVK LHEETLTYLN QGQSYEIRLL ENRKLGDFQD LNTKYVKSII RVVFHDRRLQ YTEYQQLEGW RWSRPGDRIL DIDIPLSVGI LDPRASPTQL NAVEFLWDPS KRASAFIQVH CISTEFTPRK HGGEKGVPFR VQIDTFKQNE SGDYSEHLHS ASCQIKVFKP KGADRKQKTD REKMEKRTAQ EKEKYQPSYE TTILTECSPW PDVPYQANNT PSPSYNGSPN SFGLREGNSS PNHPVEPLPL GSDHLLPSAS IQDAQQWLHR NRFSQFCWLF ASFSGADLLK MSRDDLVQVC GPADGIRLFN AIKGRNVRPK MTIYVCQELE QNQLPLPQKQ DDSGDNSLCV YHAIFLEELT TLELTEKIAS LYSIPPQHIH RVYRQGPAGI HVVVSNEMVQ NFQDESCFIL STLKAESNDG YHIILKCGL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor that facilitates establishment and maintenance of pluripotency in embryonic stem cells (ESCs). With Klf2, acts as the major effector of self-renewal that mediates induction of pluripotency downstream of LIF/Stat3 and Wnt/beta-catenin signaling. Required for normal duct development in the salivary gland and kidney. Coordinates the development of the kidney collecting ducts intercalated (IC) and principal (PC) cells, which regulate acid-base and salt-water homeostasis, respectively. Regulates the expression of IC genes including subunits B1 and D2 of the V-ATPase complex, Oxgr1, Ca12, Slc4a1, Aqp6 and IC-specific transcription factor Foxi1. Regulates also the expression of Jag1 and subsequent notch signaling in the collecting duct. Jag1 initiates notch signaling in PCs but inhibits notch signaling in ICs. Acts as a transcriptional suppressor that may suppress UBP1-mediated transcriptional activation. Modulates the placental expression of CYP11A1.
  • 基因功能参考文献：
    1. Thus, Tfcp2l1 is a critical regulator of intercalated cell-principal cell patterning in kidney collecting ducts, acting cell-autonomously in intercalated cells, and non-cell-autonomously in principal cells. PMID: 28577314
    2. TFCP2L1 depends on its N-terminus and CP2-like domain to maintain the undifferentiated state of mouse embryonic stem cells. PMID: 28982712
    3. we found that TFCP2L1 is hexamerized in solution via the C-terminal SAM-like domain. We also found that homo-oligomerization of SAM-like domain is dependent on the concentration of the proteins. PMID: 26906118
    4. study therefore establishes the pivotal role of Klf2 and Tfcp2l1 in mediating ESC self-renewal promoted by Wnt/beta-catenin signaling. PMID: 26321140
    5. Tfcp2l1 is the principal bridge between LIF/Stat3 input and the transcription factor core of naive pluripotency. PMID: 23942233
    6. Tfcp2l1 is at the intersection of LIF- and 2i-mediated self-renewal pathways and plays a critical role in maintaining embryonic stem cell identity. PMID: 23942238
    7. Cp2l1 expression is required for normal duct development in both the salivary gland and kidney. PMID: 17079272

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Grh/CP2 family, CP2 subfamily
  • 组织特异性：
    Highly expressed in placenta, testis, small intestine, kidney and stomach. Low levels of expression in lung, mesenteric lymph nodes, muscle, ovary, and thymus. No expression was detected in brain, heart, liver, and spleen. Expressed in eccrine glands in t
  • 数据库链接：

    KEGG: mmu:81879

    STRING: 10090.ENSMUSP00000027629

    UniGene: Mm.24621