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  4. Recombinant Mouse Transcription factor LBX1 (Lbx1)

Recombinant Mouse Transcription factor LBX1 (Lbx1)

  • 中文名称：
    小鼠Lbx1重组蛋白
  • 货号：
    CSB-YP012777MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Lbx1重组蛋白
  • 货号：
    CSB-EP012777MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Lbx1重组蛋白
  • 货号：
    CSB-EP012777MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Lbx1重组蛋白
  • 货号：
    CSB-BP012777MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Lbx1重组蛋白
  • 货号：
    CSB-MP012777MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Lbx1
  • Uniprot No.：
  • 别名：
    Lbx1; Lbx1h; Transcription factor LBX1; Ladybird homeobox protein homolog 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-282
  • 氨基酸序列
    MTSKEDGKAA PGEERRRSPL DHLPPPANSN KPLTPFSIED ILNKPSVRRS YSLCGAAHLL AAADKHAPGG LPLAGRALLS QTSPLCALEE LASKTFKGLE VSVLQAAEGR DGMTIFGQRQ TPKKRRKSRT AFTNHQIYEL EKRFLYQKYL SPADRDQIAQ QLGLTNAQVI TWFQNRRAKL KRDLEEMKAD VESAKKLGPS GQMDIVALAE LEQNSEASGG GGGGGCGRAK SRPGSPALPP GAPQAPGGGP LQLSPASPLT DQRASSQDCS EDEEDEEIDV DD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and hypoglossal cord.
  • 基因功能参考文献：
    1. Chmp2b is one of the most highly regulated cell-autonomous targets of Lbx1 in the embryonic mouse neural tube PMID: 23284619
    2. Lbx1 is expressed in and required for the correct specification of three early dorsal interneuron populations and late-born neurons that form the substantia gelatinosa. Lbx1 plays a critical role in the development of sensory pathways in the spinal cord. PMID: 12062038
    3. Lbx1 is required for correct dorsal-ventral patterning of the neural tube. Lbx1/Pax3 double-mutant mice showed a completely open neural tube. PMID: 12358782
    4. Inactivation of the Lbx1 gene in mice resulted in defects in heart looping, changes in gene expression pattern, and increased cell division; Pax3 and Lbx1 participate in negative regulatory feedback PMID: 12522123
    5. Corl1 interacted with Lbx1 and cooperatively repressed transcription, suggesting that it acts as a transcriptional corepressor for Lbx1 in regulating cell fate determination in the dorsal spinal cord. PMID: 15528197
    6. Lbx1 and Tlx3 are opposing switches in determining GABAergic versus glutamatergic transmitter phenotypes. PMID: 16234809
    7. Homeobox gene Lbx1 is essential for imposing a somatosensory fate on relay neurons in the hindbrain. PMID: 17475798
    8. Functional analysis of homeodomain-containing transcription factor Lbx1 in satellite cells of mouse skeletal muscle is reported. PMID: 18003701
    9. The respiratory rhythm generation within the pre-Botzinger complex (preBotC) is presumably functional in Lbx1 mutant mice with additional neurochemical drive. PMID: 18945911

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed in the dorsal part of the spinal cord and hindbrain and in presumptive myogenic cells in lateral regions of differentiating somites.
  • 数据库链接：

    KEGG: mmu:16814

    STRING: 10090.ENSMUSP00000096997

    UniGene: Mm.116815