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  4. Recombinant Mouse Transcription factor SOX-21 (Sox21)

Recombinant Mouse Transcription factor SOX-21 (Sox21)

  • 中文名称：
    小鼠Sox21重组蛋白
  • 货号：
    CSB-YP800391MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Sox21重组蛋白
  • 货号：
    CSB-EP800391MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Sox21重组蛋白
  • 货号：
    CSB-EP800391MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Sox21重组蛋白
  • 货号：
    CSB-BP800391MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Sox21重组蛋白
  • 货号：
    CSB-MP800391MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Sox21; Transcription factor SOX-21
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-276
  • 氨基酸序列
    MSKPVDHVKR PMNAFMVWSR AQRRKMAQEN PKMHNSEISK RLGAEWKLLT ESEKRPFIDE AKRLRAMHMK EHPDYKYRPR RKPKTLLKKD KFAFPVPYGL GSVADAEHPA LKAGAGLHAG AGGGLVPESL LANPEKAAAA AAAAAARVFF PQSAAAAAAA AAAAAAGSPY SLLDLGSKMA EISSSSSGLP YASSLGYPTA GAGAFHGAAA AAAAAAAAAG GHTHSHPSPG NPGYMIPCNC SAWPSPGLQP PLAYILLPGM GKPQLDPYPA AYAAAL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play a role as an activator of transcription of OPRM1. Overexpression of SOX21 can up-regulate the OPRM1 distal promoter activity in mor-expressing neuronal cells.
  • 基因功能参考文献：
    1. the expression of Sox21 in hypothalamic-pituitary development was examined. PMID: 27616671
    2. Low SOX21 expression is associated with Glioma. PMID: 28687615
    3. Following elevation of the palatal shelves (E14.5), Sox2, Sox11 and Sox21 expression was present in the midline epithelial seam. We thus identify dynamic spatio-temporal expression of Sox gene family during the process of palatogenesis PMID: 27241892
    4. Study identifies CARM1, which methylates histone H3 at arginine 26 (H3R26), as an upstream regulator of Sox21 expression. These results indicate that heterogeneity in gene expression patterns biases cell fate in the mouse embryo as early as the 4-cell stage. PMID: 27015307
    5. results implicate Sox21 specifically in the promotion of spongiotrophoblast and giant cell differentiation and establish a new mechanism through which trophoblast sublineages are specified PMID: 26491013
    6. The effects of Sox21 gene deletion on hair lipids have been studied. PMID: 23171466
    7. results show that transcriptional induction of Sox21 is a rapid and general mediator of the effects of Sox2 on cell identity in a wide range of cell types PMID: 22902753
    8. Sox21 repressed Hes5 gene expression at the transcriptional level in hippocampus adult neurogenesis. PMID: 22956844
    9. Sox21, a counteracting partner of the SoxB1 family, controls fine-tuned cell fate decisions PMID: 21287267
    10. Findings suggest that bivalent genes, such as Sox21, are silenced by a complex set of redundant repressive machinery, which exit rapidly in response to appropriate differentiation signals. PMID: 20876214
    11. Data show that ectopic expression of Sox21 in ESC induces their differentiation into specific cell types, including those that express markers representative of neurectoderm and heart development. PMID: 20687156
    12. Overexpression of Sox21 results in a substantial repression of NGF-induced neurite outgrowth in PC12 cells. Y-box binding protein 1 not only binds to Sox21 but also partially restores NGF-induced neurite outgrowth of PC12 cells inhibited by Sox21. PMID: 15039105
    13. These results indicate that Sox21 is a master regulator of hair shaft cuticle differentiation and shed light on the possible causes of human hair disorders. PMID: 19470461

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    KEGG: mmu:223227

    UniGene: Mm.70950