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  4. Recombinant Mouse Transcription factor SOX-4 (Sox4)

Recombinant Mouse Transcription factor SOX-4 (Sox4)

  • 中文名称：
    小鼠Sox4重组蛋白
  • 货号：
    CSB-YP022431MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Sox4重组蛋白
  • 货号：
    CSB-EP022431MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Sox4重组蛋白
  • 货号：
    CSB-EP022431MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Sox4重组蛋白
  • 货号：
    CSB-BP022431MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Sox4重组蛋白
  • 货号：
    CSB-MP022431MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Sox4
  • Uniprot No.：
  • 别名：
    Sox4; Sox-4; Transcription factor SOX-4
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-440
  • 氨基酸序列
    MVQQTNNAEN TEALLAGESS DSGAGLELGI ASSPTPGSTA STGGKADDPS WCKTPSGHIK RPMNAFMVWS QIERRKIMEQ SPDMHNAEIS KRLGKRWKLL KDSDKIPFIQ EAERLRLKHM ADYPDYKYRP RKKVKSGNAG AGSAATAKPG EKGDKVAGSS GHAGSSHAGG GAGGSSKPAP KKSCGPKVAG SSVGKPHAKL VPAGGSKAAA SFSPEQAALL PLGEPTAVYK VRTPSAATPA ASSSPSSALA TPAKHPADKK VKRVYLFGSL GASASPVGGL GASADPSDPL GLYEDGGPGC SPDGRSLSGR SSAASSPAAS RSPADHRGYA SLRAASPAPS SAPSHASSSL SSSSSSSSGS SSSDDEFEDD LLDLNPSSNF ESMSLGSFSS SSALDRDLDF NFEPGSGSHF EFPDYCTPEV SEMISGDWLE SSISNLVFTY
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif. Required for IL17A-producing Vgamma2-positive gamma-delta T-cell maturation and development, via binding to regulator loci of RORC to modulate expression.
  • 基因功能参考文献：
    1. Sox4 expression levels are markedly upregulated in livers of obese rodents and humans. Adenovirus-medicated overexpression of Sox4 in the livers of lean mice promotes liver steatosis, whereas liver-specific knockdown of Sox4 ameliorates triglyceride accumulation and improves insulin resistance in obese mice. PMID: 30181160
    2. Sox4 promoted tuft and enteroendocrine cell lineage allocation independently of Atoh1. These results challenge the longstanding model in which Atoh1 is the sole regulator of secretory differentiation in the intestine and are relevant for understanding epithelial responses to parasitic infection. PMID: 30055169
    3. SOX4 (and, to a lesser extent, SOX11 and -12) repressed transcription of the sex-determining gene Sox9 via an upstream testis-specific enhancer core (TESCO) element in fetal gonads. PMID: 28118982
    4. These data suggest that increased SOX4 expression inhibits insulin secretion and increased diabetes risk by the upregulation of STXBP6 and an increase in kiss-and-run exocytosis at the expense of full fusion. PMID: 26993066
    5. Taken together, our findings indicate that miR-363-3p is involved in CRC metastasis and functions as a tumor suppressor via negatively regulating Sox4. Therefore, the up-regulation of miR-363-3p in human CRC may have therapeutic benefits. PMID: 27084453
    6. Sox4 sense and natural antisense transcripts formed dsRNA aggregates in the cytoplasm of brain cells. Over expression of Sox4 NATs in NIH/3T3 cells generally did not alter the level of Sox4 mRNA expression or protein translation. Upregulation of a Sox4 NAT known as Sox4ot1 led to the production of a novel small RNA, Sox4_sir3. PMID: 26802803
    7. The microRNA-212/micro-132 cluster regulates B cell development by targeting Sox4. PMID: 26371188
    8. The expression of putative SOX4 target genes during myoblast differentiation is specifically regulated by the molecular switching of the co-activator KAT5 and the co-repressor HDAC1 on SOX4 transcriptional activation. PMID: 26291311
    9. Sox4 contributes to the regulation of Schwann cell myelination, and also indicates its involvement in the pathophysiology of peripheral neuropathies. PMID: 25899854
    10. Sox4 and Sox11 are down-regulated after the epoch of auditory hair cell development and thus make work as targets for the restoration of hearing and balance. PMID: 26504244
    11. These results demonstrate that SOX4 is essential for normal endocrine pancreas development both concomitant with, and downstream of, the endocrine fate decision. PMID: 25652387
    12. SOX4 is a new regulator of liver development and that it exerts a pleiotropic control on bile duct development in cooperation with SOX9. PMID: 26033091
    13. Sox4-deficient mice age prematurely and are cancer resistant. PMID: 25043184
    14. Mutation of murine Sox4 untranslated regions results in partially penetrant perinatal lethality. PMID: 25189881
    15. Sox4 and Tcf7l1 form a functional axis that promotes the progression of BCR-ABL-positive acute lymphoblastic leukemia. PMID: 24997151
    16. At the molecular level, Sox4 orchestrates a unique gene regulatory program, and its function was predominantly mediated through a conventional Sox4-binding motif as well as an unconventional GA-binding protein alpha chain binding motif. PMID: 24786772
    17. Overexpression of CaD in Sox4-silenced C2C12 cells rescued the differentiation process. These results clearly demonstrate that CaD, regulated by Sox4 transcriptional activity, contributes to skeletal muscle differentiation. PMID: 24046453
    18. Sry-related HMG box-4 (SOX4) is required for normal mouse renal development in vivo PMID: 23559562
    19. PML-RARalpha co-operates with Sox4 in acute myeloid leukemia development in mice. PMID: 23144197
    20. Our studies indicate that Sox4 is an epigenetically regulated gene that likely integrates multiple signaling systems for mediating palatal fusion, palatal extension and/or the maintenance of the neural stem cell niche in the rugae. PMID: 23566091
    21. Sox4 is identified as a master regulator of EMT by governing the expression of the epigenetic modifier Ezh2. PMID: 23764001
    22. Data suggest that Notch signaling suppresses Sox4 expression in early developing retina but not during later period of development; histone H3 methylation at Sox4 gene is low during retinal development but increases markedly in adult retina. PMID: 23313252
    23. Sox4 is required for the survival of pro-B cells and may functionally interact with c-Kit and Bcl2. PMID: 23345330
    24. SOX4 gene expression was up-regulated in murine BCR-ABL1-driven pre-BALL by tyrosine kinase inhibitor treatment. It binds to and transcriptionally activates promoters of multiple components within the PI3K/AKT & MAPK signaling pathways. PMID: 23152540
    25. Sox4 was induced by TGF-beta and negatively regulated the transcription factor GATA-3, the master regulator of function of T helper type 2 TH2 cells, by two distinct mechanisms. PMID: 22751141
    26. Sox4 and CREB cooperate and contribute to increased proliferation of hematopoietic progenitor cells. PMID: 22627767
    27. a concerted rearrangement of two interface amino acids enables Sox4 to accommodate primary and secondary motifs, the structural adaptations lead to altered dinucleotide preferences that mutually reinforce each other PMID: 22181698
    28. Overexpression of Sox4 and Sox11 promotes neurogenesis from adult neural stem cells (NSCs), whereas ablation of Sox4/Sox11 prevents in vitro and in vivo neurogenesis from adult NSCs. PMID: 22378879
    29. In situ hybridization reveals Tbx3 and Sox4 to co-localize extensively in the embryo including the atrioventricular and outflow tract cushion mesenchyme and a small area of interventricular myocardium. PMID: 21538160
    30. Sox4 protein directly function as pro-survival factors during spinal cord development in neural cell types PMID: 20646169
    31. Sox transcription factors are expressed in the developing pancreas and in the islets of Langerhans and Sox4is required for the normal development of pancreatic islets. PMID: 16306355
    32. Prolonged Sox4 expression in cells of the oligodendrocyte lineage is incompatible with the acquisition of a fully mature phenotype. PMID: 17515609
    33. These results implicate the transcription factor Sox4 in regulation of bone formation, by acting upstream of Osx and independent of Runx2. PMID: 17652162

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed in both gamma-delta T-cells and Cd4+ Cd8+ double-positive (DP) alpha-beta T-cells. Expressed in the ovaries and the thymus.
  • 数据库链接：

    KEGG: mmu:20677

    STRING: 10090.ENSMUSP00000100013

    UniGene: Mm.240627