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  4. Recombinant Mouse Transcription factor jun-D (Jund)

Recombinant Mouse Transcription factor jun-D (Jund)

  • 货号：
    CSB-YP011974MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP011974MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP011974MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP011974MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP011974MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Jund; Jun-d; Jund1; Transcription factor jun-D
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-341
  • 氨基酸序列
    METPFYGEEA LSGLAAGASS VAGATGAPGG GGFAPPGRAF PGAPPTSSML KKDALTLSLA EQGAAGLKPG SATAPSALRP DGAPDGLLAS PDLGLLKLAS PELERLIIQS NGLVTTTPTS TQFLYPKVAA SEEQEFAEGF VKALEDLHKQ SQLGAATAAT SGAPAPPAPA DLAATPGATE TPVYANLSSF AGGAGPPGGA ATVAFAAEPV PFPPPPGALG PPPPPHPPRL AALKDEPQTV PDVPSFGDSP PLSPIDMDTQ ERIKAERKRL RNRIAASKCR KRKLERISRL EEKVKTLKSQ NTELASTASL LREQVAQLKQ KVLSHVNSGC QLLPQHQVPA Y
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor binding AP-1 sites.
  • 基因功能参考文献：
    1. Differentiation-mediated activation of JunD results in enhanced TUBB4a expression in P19 embryonal carcinoma cells. PMID: 25649943
    2. JunD provides protection in aging-induced endothelial dysfunction and may represent a novel target to prevent reactive oxygen species-driven vascular aging. PMID: 23410942
    3. Nfe2 modulates JunD binding to the Gcm1 promoter via acetylation PMID: 22174410
    4. 5-HT2B blockade enhances liver regeneration by inhibiting induction of TGF-beta1 expression by hepatic stellate cells that is dependent on 5-HT, ERK and JunD. PMID: 22120177
    5. Downregulation of JunD and cyclin D1 expression in myofibroblasts may be important regarding the mechanism of action of MTA in Mdr2-/- mice PMID: 21209952
    6. Study supports potential roles for jun D, jun B, and fra-1 in the dietary energy restriction regulation of AP-1 function in the Sencar mouse skin carcinogenesis model. PMID: 20232358
    7. protects cells from p53-dependent senescence and apoptosis PMID: 11106750
    8. Translation initiation from alternative AUG and non-AUG sites in human, mouse and rat. PMID: 12105216
    9. Transcriptional activation of Ifi202 gene by Rb/JunD may be important for the regulation of cell growth and survival. PMID: 12894219
    10. Data suggest that JunD is part of a regulatory network that controls proliferation to prevent pathological progression in chronic renal diseases. PMID: 12975469
    11. regulatory role of JunD in T lymphocyte proliferation and Th cell differentiation PMID: 15029240
    12. menin suppresses osteoblast maturation, in part, by inhibiting the differentiation actions of JunD PMID: 15563473
    13. junD promotes both adaptive-protective and maladaptive hypertrophy in heart, depending on its expression levels. PMID: 15655111
    14. JunD limits cardiomyocyte hypertrophy and protects the pressure-overloaded heart from cardiac apoptosis PMID: 16129800
    15. stimulation of splenic B cells with IL-4 or IL-21 induced high Bcl6 expression with induction of junD PMID: 16702165
    16. In conclusion, a signaling pathway for the development of fibrosis involves the regulation of TIMP-1 expression by phosphorylated JunD. PMID: 17133482
    17. These data identify junD proto-oncogene (JunD) and Fos-related antigen 2 (Fra-2) as the activator protein-1 (AP-1) factors responsible for the RANKL-induced upregulation of the mouse Tcirg1 gene expression. PMID: 17419679
    18. both UV and H(2)O(2 )induce the activation of c-Fos/JunD AP-1 complexes resulting in the prevention of cell death PMID: 17531086
    19. JunD counterbalances JNK1 activation and the downstream redox-dependent hepatic injury that results from I/R, and may do so by regulating NADPH oxidases PMID: 18182393
    20. JunD is involved in estrogen depletion-induced osteopenia via its action to suppress bone formation and to enhance bone resorption. PMID: 18240141
    21. JunD-menin complex plays significant roles in the androgen-dependent differentiation of the duct system in the mouse submandibular gland PMID: 18323693

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    BZIP family, Jun subfamily
  • 组织特异性：
    Brain and kidney.
  • 数据库链接：

    KEGG: mmu:16478

    STRING: 10090.ENSMUSP00000092901

    UniGene: Mm.419851