Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Mouse Transcriptional activator Myb (Myb)

Recombinant Mouse Transcriptional activator Myb (Myb)

  • 货号：
    CSB-YP015261MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP015261MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP015261MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP015261MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP015261MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Myb; Transcriptional activator Myb; Proto-oncogene c-Myb
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-636
  • 氨基酸序列
    MARRPRHSIY SSDEDDEDIE MCDHDYDGLL PKSGKRHLGK TRWTREEDEK LKKLVEQNGT DDWKVIANYL PNRTDVQCQH RWQKVLNPEL IKGPWTKEED QRVIELVQKY GPKRWSVIAK HLKGRIGKQC RERWHNHLNP EVKKTSWTEE EDRIIYQAHK RLGNRWAEIA KLLPGRTDNA IKNHWNSTMR RKVEQEGYLQ EPSKASQTPV ATSFQKNNHL MGFGHASPPS QLSPSGQSSV NSEYPYYHIA EAQNISSHVP YPVALHVNIV NVPQPAAAAI QRHYNDEDPE KEKRIKELEL LLMSTENELK GQQALPTQNH TCSYPGWHST SIVDQTRPHG DSAPVSCLGE HHATPSLPAD PGSLPEESAS PARCMIVHQG TILDNVKNLL EFAETLQFID SFLNTSSNHE SSGLDAPTLP STPLIGHKLT PCRDQTVKTQ KENSIFRTPA IKRSILESSP RTPTPFKHAL AAQEIKYGPL KMLPQTPSHA VEDLQDVIKQ ESDESGIVAE FQESGPPLLK KIKQEVESPT EKSGNFFCSN HWAENSLSTQ LFSQASPVAD APNILTSSVL MTPVSEDEDN VLKAFTVPKN RPLVGPLQPC SGAWEPASCG KTEDQMTASG PARKYVNAFS ARTLVM
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.
  • 基因功能参考文献：
    1. This study provides evidence that c-Myb might serve as a new target for the prevention of aminoglycoside-induced hair cells loss. PMID: 28112219
    2. these results identify a key role for miR-150 in memory CD8 T cells through a c-Myb-controlled enhanced survival circuit. PMID: 28903040
    3. Myb knockdown in Setbp1 and Setbp1 missense mutations-induced AML cells also efficiently induced their differentiation in culture and significantly prolonged the survival of their secondary recipient mice. PMID: 27863435
    4. These findings reveal miR-301b as a new controller of inflammatory response by repressing c-Myb function to inhibit the anti-inflammatory response to bacterial infection, representing a novel mechanism for balancing inflammation. PMID: 27670114
    5. Data suggest that the upregulations of Myb and Peg3 are likely the key anti-cancer events of EGCG in vivo. PMID: 27461468
    6. deficiency alters the expression of a crucial subset of TAL1- and NOTCH1-regulated genes, including the MYB and MYC oncogenes, respectively. PMID: 28790107
    7. MYB acts on MAPK signaling by directly regulating transcription of the gene encoding the negative modulator SPRY2. PMID: 27748374
    8. This work provides important mechanistic insight into how spatiotemporal expression of the Rag genes is tightly controlled during B lymphocyte development to prevent mistimed dsDNA breaks and their deleterious consequences. PMID: 28373291
    9. These results Myb as a critical component of the gene regulatory network controlling effector Treg cell differentiation and function. PMID: 28099866
    10. Production of dendritic-like cells and resident monocytes was not affected by the c-MybE308G mutation. PMID: 28445549
    11. Myb expands the ISC pool within which CRC is initiated while co-operating with TSG loss PMID: 26300002
    12. c-Myb regulates proliferation/differentiation of adventitial Sca1+ vascular smooth muscle progenitor cells by transcriptional activation of myocardin. PMID: 27174098
    13. the key role of the transcription factor c-Myb in regulating the T-bet-mediated anti-viral program, is reported. PMID: 28423310
    14. p38 and NOX1 are essential for the protective effect of c-Myb and that NOX1 acts upstream of p38 activation. PMID: 27107996
    15. These findings reveal that miR-150 acts as a pivotal regulator of pressure overload-induced cardiac fibrosis by regulating c-Myb. PMID: 27184887
    16. MYB and C/EBPalpha activities are inter-dependent in controlling Flt3 expression to influence lineage commitment of multipotential progenitors. PMID: 26382271
    17. Myb regulates Cyclin E1 expression in normal gastrointestinal tract epithelial cells and is required during intestinal tumorigenesis PMID: 25934694
    18. Identify regulatory link between Nkx2-1, miR-200c, and the transcription factors Nfib and Myb, adding new players to the regulatory mechanisms driven by Nkx2-1 in lung epithelial cells that may have implications in lung development and tumorigenesis. PMID: 25763778
    19. Myb has a role in K14+ epithelial cells in the preservation of mouse adult skin integrity and function in a process involving TGFbeta and collagen type I PMID: 25807069
    20. results of this study demonstrate that the c-Myb transcription factor is involved in the regulation and promotion of endochondral bone formation PMID: 25845979
    21. The transcription factor c-Myb (Myb) is expressed preferentially by immature natural killer cells, is a direct target of miR-15/16, and is increased in 15a/16-1 floxed knockout natural killer cells. PMID: 26268657
    22. results show that a p63(-) Myb(+) population of airway epithelial cells represents a distinct intermediate stage of differentiation PMID: 25103188
    23. The discrimination of HSC subpopulations based on c-Myb protein levels is not reflected in the levels of c-myb mRNA, there being no more than a 1.3-fold difference comparing c-Myb(low) and c-Myb(high) HSCs. PMID: 25329760
    24. c-Myb plays an essential, novel role in establishing the long-lived plasma cell population in the bone marrow via responsiveness to chemokine migration cues. PMID: 26077717
    25. C-Myb(+) erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophages. PMID: 25902481
    26. c-Myb plays an important role in H-Ras-induced MKP-3 transcription PMID: 24978307
    27. these results suggest that the KIX domains of CBP, and especially p300, are principal mediators of c-Myb-dependent gene activation and repression that is required for definitive hematopoiesis. PMID: 24340053
    28. Findings indicate that c-Myb is involved in regulating the differentiation program of myogenic progenitor cells as its expression blocks myoblast fusion. PMID: 24204667
    29. GFI1B, EVI5, MYB are additional mouse genes that cooperate with the human BCL6 gene to promote the development of lymphomas. PMID: 23910958
    30. a mutant mouse model demonstrates how c-Myb with p300 is required for oncogene-induced acute myeloid leukemia PMID: 24596419
    31. Data indicate that Myb and BCL11A cooperate with DNMT1 to achieve developmental repression of embryonic and fetal beta-like human transgenic globin genes in the adult erythroid environment. PMID: 24371119
    32. of c-Myb, is detected preferentially in nonSUMOylated protein and has a negative effect on stress-induced SUMOylation of c-Myb. Stress-activated p38 MAPKs phosphorylate Thr(486) in c-Myb, attenuate its SUMOylation PMID: 24257756
    33. Ebf1 and c-Myb antagonize Rag transcription by negatively regulating the binding of Foxo1 to the Rag locus. PMID: 24068669
    34. MYB has an early, crucial and conserved role in multiciliogenesis, and it promotes a novel S-like phase in which centriole amplification occurs uncoupled from DNA synthesis, and then drives later steps of multiciliogenesis through induction of Foxj1. PMID: 24048590
    35. The interaction between Myb and p300 was shown to be essential for cellular differentiation and lineage hierarchies in hematopoiesis. PMID: 23618903
    36. Myb is an epigenetic master regulator of stem cells that differentially regulates their fate in the brain and intestine stem cell niches. (Review) PMID: 23696366
    37. c-MYB overexpression and siRNA for c-Myb affected SPHK1 expression, confirming the important regulatory role of c-MYB in SPHK1 expression. PMID: 23328083
    38. This study confirmed the presence of c-MYB protein in differentiated ameloblasts, odontoblasts, osteoblasts, cementoblasts and alveolar fibroblasts, suggesting integration of c-MYB into regulatory networks during postnatal stages of odontogenesis. PMID: 23167465
    39. Maintenance of Gata3 protein levels by Myb and Notch signaling is linked to the ability to retain T-cell identity in response to PU.1. PMID: 23444353
    40. These results demonstrate that c-myb plays a pivotal role in the regulation of multiple stages in adult myelogenesis. PMID: 22918254
    41. analysis of the three murine leukemia virus integration regions within 100 kilobases upstream of c-myb that are proximal to the 5' regulatory region of the gene through DNA looping PMID: 22811527
    42. Verapamil can inhibit fertilization in vitro through regulating Myb expression in sperm. PMID: 21166174
    43. a c-Myb-Bmi1 transcription-regulatory pathway is required for p190(BCR/ABL) leukemogenesis. PMID: 21960247
    44. The dynamic expression of miR-150 is required for normal natural killer T (NKT) cell development through controlling the proper levels of c-Myb expression. PMID: 22287707
    45. study found Myb was required for development of hematopoietic stem cells and all CD11b(high) monocytes and macrophages, but was dispensable for yolk sac (YS) macrophages and for the development of YS-derived F4/80(bright) macrophages in several tissues PMID: 22442384
    46. c-erbB(2) and c-myb may induce oocyte maturation through mediating a pathway involving the activation of MPF. PMID: 21793718
    47. Lgr5 expression is lost commensurate with Myb deletion in organoids. PMID: 21997934
    48. c-Myb is tightly regulated by proteosomal degradation during cardiovascular-directed differentiation of embryonic stem cells, expanding early-stage VEGFR2+ progenitors capable of retinoic acid-responsive smooth muscle cell formation. PMID: 22116818
    49. c-Myb expression is positively correlated with cell proliferation in prenatal odontogenesis. PMID: 21762405
    50. c-Myb and GATA-1 act in concert to achieve correct megakaryocytic differentiation. PMID: 21668739

    显示更多

    收起更多

  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    KEGG: mmu:17863

    STRING: 10090.ENSMUSP00000020158

    UniGene: Mm.473872