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  4. Recombinant Mouse Transgelin (Tagln)

Recombinant Mouse Transgelin (Tagln)

  • 中文名称：
    小鼠Tagln重组蛋白
  • 货号：
    CSB-YP023105MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Tagln重组蛋白
  • 货号：
    CSB-EP023105MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Tagln重组蛋白
  • 货号：
    CSB-EP023105MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Tagln重组蛋白
  • 货号：
    CSB-BP023105MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Tagln重组蛋白
  • 货号：
    CSB-MP023105MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tagln
  • Uniprot No.：
  • 别名：
    Tagln; Sm22; Sm22a; Transgelin; Actin-associated protein p27; Smooth muscle protein 22-alpha; SM22-alpha
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-201
  • 氨基酸序列
    ANKGPSYGM SREVQSKIEK KYDEELEERL VEWIVVQCGP DVGRPDRGRL GFQVWLKNGV ILSKLVNSLY PEGSKPVKVP ENPPSMVFKQ MEQVAQFLKA AEDYGVIKTD MFQTVDLYEG KDMAAVQRTL MALGSLAVTK NDGNYRGDPN WFMKKAQEHK RDFTDSQLQE GKHVIGLQMG SNRGASQAGM TGYGRPRQII S
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Actin cross-linking/gelling protein.
  • 基因功能参考文献：
    1. CKII-SIRT1-SM22alpha acts in a loop to reinforce the expression of SM22alpha, which limits the inflammatory response in vascular smooth muscle cells. PMID: 28419207
    2. Data (including data from studies using cells cultured from transgenic/knockout mice) suggest that expression and degradation of transgelin in myofibroblasts and keratinocytes are regulated by mechanical tension in cytoskeleton produced by myosin II motor in response to stiffness of culture matrix/extracellular matrix. PMID: 28898058
    3. Targeted elimination of TGFbetaR2 in TAGLN(+) cells impairs midline closure and prevents the correct subsequent patterning of the musculature and skeletal components. PMID: 28807903
    4. SM22alpha is a phosphorylation-regulated suppressor of IKK-IkappaBalpha-NF-kappaB signaling cascades. PMID: 25937534
    5. SM22alpha promotes ubiquitination and degradation of MKP3. SM22alpha facilitates AngII-induced contraction by maintenance of ERK1/2 signaling. PMID: 25515236
    6. TRAF6-SM22alpha-G6PD pathway is a novel mechanism underlying the association between glucose metabolism and VSMC survival, which is beneficial for vascular repair after injury but facilitates atherosclerotic plaque stability. PMID: 26291555
    7. Absent/lower SM22 alpha levels favor an increase in parietal epithelial cell transition cells and PECs expressing a progenitor marker, and a lower epithelial mesenchymal transformation rate versus SM22alpha+/+mice, where SM22 levels are increased in PECs. PMID: 25376243
    8. SM22alpha-regulated molecular pathways contribute to vascular pathology. PMID: 24735829
    9. Histological analysis did not reveal calcium deposits in the aortic roots of SM22alpha-Rankl ( tg ) mice PMID: 23052229
    10. Data show that formation of a Krupple-like factor KLF4, pELK-1, and histone de-acetylase 2 (HDAC2) multiprotein complex dependent on the SM22alpha G/C Repressor element. PMID: 22811558
    11. Data suggest that SM22alpha expression in renal tissues might be a hallmark of kidney diseases. PMID: 22205114
    12. We conclude that the de novo expression of SM22alpha in glomerular epithelial cells affects the course of crescentic glomerulonephritis. PMID: 21289056
    13. critical role for the Tsc1/Tsc2-mTORC1-S6K axis in the normal development of cardiovascular tissue PMID: 21212099
    14. SM22 downregulation can induce proinflammatory vascular smooth muscle cells through activation of ROS-mediated NF-kappaB pathways. PMID: 20224039
    15. The effects of dichloroacetate treatment on pulmonary artery smooth muscle cells and pulmonary hypertension in mice with SM22alpha-targeted overexpression of the serotonin transporter are reported. PMID: 19679640
    16. loss of transgelin gene expression may be an important early event in tumor progression and a diagnostic marker for breast and colon cancer development. PMID: 11773051
    17. Data show that SM22alpha plays a role in contractility, possibly by affecting actin filament organisation PMID: 15044015
    18. In hypercholesterolemic ApoE-deficient mice, genetic ablation of SM22alpha increased atherosclerotic lesion area & the proportion of proliferating SMC-derived plaque cells, identifing its role in the regulation of SMC phenotype during atherogenesis. PMID: 15044321
    19. a novel regulatory mechanism whereby Myocd participates in TGF-beta1 signal pathway through direct interaction with Smad3, which binds to the SBEs. PMID: 16224064
    20. Loss of transgelin is associated with ulcerative colitis-induced colon carcinogenesis PMID: 16402363
    21. Data sh ow that transgelin (SM22) is a novel repressor of 92-kDa type IV collagenase (MMP-9) expression. PMID: 16835221
    22. We conclude that TGF-beta signaling in the subset of cells that express SM22alpha is required for normal development. PMID: 16887142
    23. Analysis of these transgenes revealed that the CArG element in the telokin promoter is required for promoter activity in all tissues and that the CArG element. PMID: 17079332
    24. There is evidence for a pivotal role of SM22alpha in the regulation of Ca2+-independent vascular contractility. PMID: 17464194
    25. Smooth muscle protein 22alpha-mediated patchy deletion of Bmpr1a impairs cardiac contractility but protects against pulmonary vascular remodeling PMID: 18079409
    26. involved in calcium-independent smooth muscle contraction PMID: 18378184
    27. Loss of Bmpr1a, by decreasing MMP2 and/or MMP9 activity, can account for vascular dilatation and persistence of brain microvessels, leading to the impaired organogenesis documented in the brain. PMID: 18667463
    28. Wnt/beta-catenin signaling interacts with TGFbeta/Smad pathways to control SM22alpha gene transcription. PMID: 19344627

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Calponin family
  • 数据库链接：

    KEGG: mmu:21345

    STRING: 10090.ENSMUSP00000034590

    UniGene: Mm.283283