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  4. Recombinant Mouse Transient receptor potential cation channel subfamily V member 2 (Trpv2), partial

Recombinant Mouse Transient receptor potential cation channel subfamily V member 2 (Trpv2), partial

  • 货号：
    CSB-YP894348MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP894348MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP894348MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP894348MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP894348MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Trpv2; Grc; Transient receptor potential cation channel subfamily V member 2; TrpV2; Growth factor-regulated calcium channel; GRC; Osm-9-like TRP channel 2; OTRPC2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH.
  • 基因功能参考文献：
    1. data suggest that knockout of the TRPV2 channel may attenuate macrophage-dependent pro-inflammatory processes and result in better cardiac recovery. TRPV2 may thus represent a novel therapeutic target for treatment of patients undergoing an acute MI PMID: 28481959
    2. We conclude that TRPV2 function, as a stretch-activated channel, regulates the development of cardiomyocyte hypertrophy in response to increased afterload. PMID: 28009703
    3. These findings suggest that TRPV2 activation via actin reorganization induced by Gq and G12/13 signaling is involved in LPI-stimulated GLP-1 secretion in enteroendocrine L cells. PMID: 28533434
    4. Expression of TRPV2 was dramatically increased during the differentiation of brown adipocytes. TRPV2 might be involved in the modulation of brown adipocyte differentiation partially via a calcineurin pathway. PMID: 27318696
    5. TRPV2 channels are demonstrated here to play a key role in cation influx and dysregulation in dystrophin deficient cardiomyocytes, enhanced in stretching conditions PMID: 26803937
    6. TRPV2KO mice show cold intolerance and impaired BAT thermogenesis. PMID: 26882545
    7. TRPV2-knockout mice have impaired cardiac functional response to exercise. PMID: 26356305
    8. TRPV2 channels play a predominant role in fluid flow mechanosensitivity over that of TRPC1 and TRP melastatin (TRPM) 7. PMID: 26207028
    9. TRPV2 is involved in a stretch-activated calcium influx pathway in dystrophic cardiomyopathy, contributing to the defective cellular Ca2+ handling in this disease. PMID: 25616416
    10. We found that NA indeed potentiated TRPV3 while inhibited TRPV2 and TRPV4 PMID: 25752528
    11. This study evaluated the role of Trpv2 in arthritis and the pharmacological effects of Trpv2 agonists. PMID: 25869297
    12. This study suggests that TRPV2 coupled with IGF-IR localizes to growing olfactory axons in the olfactory sensory neurons. PMID: 25451840
    13. Compared to Wt mice, reduced severity of colitis in TRPV2-/- mice may be due to less intestinal inflammation via reduced recruitment of macrophages. PMID: 24965783
    14. Cannabidiol rapidly increased TRPV2 expression and caused the translocation of TRPV2 to the cell membrane. PMID: 24641282
    15. Sarcolemmal TRPV2 accumulation appears to have considerable pathological impact on Dilated cardiomyopathy (DCM) progression. PMID: 23786999
    16. the activity of this channel is necessary for normal cardiac function PMID: 24322617
    17. TRPV2 is functionally expressed in astrocytes in addition to neurons. PMID: 24161738
    18. angiotensin-receptor-associated-protein and TRPV2 channel have roles in Angiotensin-2-mediated Ca2+ signaling in the retinal pigment epithelium PMID: 23185387
    19. Mechanosensitive TRPV2 was expressed in inhibitory motor neurons in the mouse stomach and contributed to gastric adaptive relaxation and gastric emptying PMID: 23203157
    20. TRPV2 may play an important role in several central nervous system networks that regulate body fluid homeostasis, autonomic function, and metabolism. PMID: 22750329
    21. Klotho enhances glucose-induced insulin secretion by up-regulating plasma membrane levels of TRPV2 in MIN6 beta-cells PMID: 22597535
    22. TRPV2 is localized abundantly in the podosome and increases [Ca(2+)](pm) by the podosome. PMID: 22226146
    23. TRPV2 is important for perinatal viability but is not essential for heat or mechanical nociception or hypersensitivity in the adult mouse. PMID: 21832173
    24. Ca(2+) oscillations in preosteoclasts are triggered by RANKL-dependent TRPV2 PMID: 20980052
    25. Insulin treatment induces the acceleration of the exocytotic response by insertion of TrpV2 into the plasma membrane in beta cells. PMID: 20854263
    26. TRPV2 is involved in LPS-induced Ca2+ mobilization and induction of cytokines in RAW264 macrophages. PMID: 20599720
    27. TRPV2 is an important regulator for axon outgrowth through its activation by membrane stretch during development. PMID: 20357111
    28. Demonstrate functional expression of TRPV4, TRPV2, and TRPM7 in mouse urothelial cells. PMID: 20015940
    29. TRPV2-deficient mice show accelerated mortality and greater organ bacterial load when challenged ti Listeri monocytogenes PMID: 20118928
    30. Study points out the role of TRPV2 channel in the physiopathology of Duchenne muscular dystrophy. PMID: 19840792
    31. analysis of glycosylation and localization in comparison to the endogenously expressed protein in F-11 cells PMID: 14622291
    32. Normal heat responses are present in IB4-positive neurons in the absence of TRPV2. PMID: 15254097
    33. TRPV2 is expressed predominantly in the NT-3-dependent subpopulation of DRG neurons throughout development and in adult mice. PMID: 15561438
    34. These results suggest that TRPV2 is specifically activated by probenecid and that this chemical might be useful for investigation of pain-related TRPV2 function. PMID: 17850966
    35. expressed in hair cells and supporting cells of the organ of Corti, in spiral ganglion cells, sensory cells in vestibular end organs, vestibular ganglion cells, sensory nerve fibers, the stria vascularis, dark cells, and endolymphatic sac PMID: 18607942
    36. TRPV2 is regulated by insulin and is involved in the autocrine action of this hormone on beta-cells. PMID: 18984736
    37. Dominant-negative TRPV2 ameliorates muscle pathology in mdx mice and hamsters by preventing abnormal Ca2+ influx. PMID: 19050039
    38. TRPV-2 was found to be localized in the mouse olfactory and respiratory epithelium.It may have a role in peripheral and central olfactory/trigeminal interaction in nasal chemoreception. PMID: 19839244

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Cytoplasm. Melanosome. Note=Translocates from the cytoplasm to the plasma membrane upon ligand stimulation.
  • 蛋白家族：
    Transient receptor (TC 1.A.4) family, TrpV subfamily, TRPV2 sub-subfamily
  • 组织特异性：
    Abundantly expressed in spleen, placenta, skeleton muscle, lung and brain.
  • 数据库链接：

    KEGG: mmu:22368

    STRING: 10090.ENSMUSP00000018651

    UniGene: Mm.288064