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  4. Recombinant Mouse Tripartite motif-containing protein 14 (Trim14)

Recombinant Mouse Tripartite motif-containing protein 14 (Trim14)

  • 货号：
    CSB-YP803945MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP803945MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP803945MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP803945MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP803945MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Trim14
  • Uniprot No.：
  • 别名：
    Trim14; Kiaa0129; Pub; Tripartite motif-containing protein 14; PU.1-binding protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-440
  • 氨基酸序列
    MASETTEARA PFQPDGAYGW RCPEHSERPA ELFCRRCGRC VCALCPVLGA HRGHPVGLAE EEAVRVQKLI QDCLECLATK KRQHADNIAH LEDAGERLKV YADSSKAWLT QKFTELRLLL DEEEVLAKKF IDKSTQLTLQ VYREQAETCG KQIEVMDDFS TRVWGIGQEP NPVQLLQAYI ATKTEMGQQM SPSELSHPVP LSFEPVKNFF KEFVEAIGNT LQTPMDTRLK ENINCQLSNS SSTKPGALLK TSPSPERALF LKYARTPTLD PDTMHARLRL SPDGLTVRCS LLGRLGPRPA PRFDALRQVL GRDGFAAGRH YWEVDVQEAG VGWWVGAAYP SLRRRGASAA ARLGCNRESW CVKRYDLEYW AFHDGQRSRL RPRRDPHRLG VFLDYEAGIL AFYDVAGGMS HLHTFHAAFQ EPLYPALRLW EGPISIPRLP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a role in the innate immune defense against viruses. Facilitates the type I IFN response by interacting with MAVS at the outer mitochondria membrane and thereby recruiting NF-kappa-B essential modulator IKBKG/NEMO to the MAVS signalosome, leading to the activation of both the IFN regulatory factor 3/IRF3 and NF-kappa-B pathways. Positively regulates the CGAS-induced type I interferon signaling pathway by stabilizing CGAS and inhibiting its autophagic degradation. Inhibits the transcriptional activity of SPI1 in a dose-dependent manner.; Plays an essential role in the innate immune defense against viruses and bacteria. Facilitates the type I IFN response by interacting with MAVS at the outer mitochondria membrane and thereby recruiting NF-kappa-B essential modulator IKBKG/NEMO to the MAVS signalosome, leading to the activation of both the IFN regulatory factor 3/IRF3 and NF-kappa-B pathways. Positively regulates the CGAS-induced type I interferon signaling pathway by stabilizing CGAS and inhibiting its autophagic degradation. Acts as a scaffold between TBK1 and STAT3 to promote phosphorylation of STAT3 and resolve interferon-stimulated gene (ISG) expression. Inhibits the transcriptional activity of SPI1 in a dose-dependent manner.
  • 基因功能参考文献：
    1. study identifies new gene-type zinc finger protein 125 (RNF125) as a negative regulator of TRIM14 in the innate antiviral immune response PMID: 28476934
    2. TRIM14 inhibits cGAS degradation mediated by selective autophagy receptor p62 to promote innate immune responses. PMID: 27666593
    3. These results demonstrate the presence of the similar mechanism of trim14 gene action in different types of mammalian cells. PMID: 24092016
    4. Pub gene participates in early stages of differentiation of embryonic stem cells leading to the formation of embryoid bodies. PMID: 16254642
  • 亚细胞定位：
    Mitochondrion outer membrane. Cytoplasmic vesicle, phagosome.
  • 蛋白家族：
    TRIM/RBCC family
  • 组织特异性：
    Expressed with high level in spleen, thymus, liver and testis. Expressed with low level in the brain, kidney, and skeletal muscle. Expressed in various differentiation stages of B-lymphocytes.
  • 数据库链接：

    KEGG: mmu:74735

    STRING: 10090.ENSMUSP00000038719

    UniGene: Mm.240252