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  4. Recombinant Mouse Tripartite motif-containing protein 6 (Trim6)

Recombinant Mouse Tripartite motif-containing protein 6 (Trim6)

  • 货号：
    CSB-YP803854MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP803854MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP803854MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP803854MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP803854MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Trim6
  • Uniprot No.：
  • 别名：
    Trim6; Tripartite motif-containing protein 6; EC 2.3.2.27; RING-type E3 ubiquitin transferase TRIM6
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-488
  • 氨基酸序列
    MTSTVLVDIR DEVTCPICLE LLTEPLSIDC GHSFCQVCII GNSNNSVFGQ GGRSSCPVCR TSYQPGNLRP NRHLAAIVKR LREVALCPGK QLEVIFCALH GEKLQLFCKE DGKLICWLCE RSQEHRGHHT FLMEEVAQEY QDMFQESLKK LRREQQEAEK LKALIQEKRE SWKSQVEPEK RRIQTEFKQL RSILDREEQR ELKKLEVEER KGLSIIEKAE GDLIHQSQSL KDLISDLEHR CQGSTVELLQ DVGDVTKRSE FWTLRKPQAL PTKLKSLFRA PDLRKMLKVF RELTDVQSYW VDVTLNPQTA NLNLVLSKNR RQVRFVGAQL SEPSSLEEHY DCSVLGSQHF SSGKYYWEVD VSKKTAWILG VCSTPVDPMF SFSQYSSKQG AYSRYQPQCG YWVIGLQCKH EYRAYEDSSP SLLLSMTVPP RRIGIFLDCE AGTVSFYNVT NHGLPIYTFS KYYFPSALCP YFNPCSCIVP MTLRRPTS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    E3 ubiquitin ligase that plays a crucial role in the activation of the IKBKE-dependent branch of the type I interferon signaling pathway. In concert with the ubiquitin-conjugating E2 enzyme UBE2K, synthesizes unanchored 'Lys-48'-linked polyubiquitin chains that promote the oligomerization and autophosphorylation of IKBKE leading to stimulation of an antiviral response. Ubiquitinates also MYC and inhibits its transcription activation activity, maintaining the pluripotency of embryonic stem cells.
  • 基因功能参考文献：
    1. TRIM6 regulates the transcriptional activity of Myc during the maintenance of cell pluripotency, suggesting that TRIM6 functions as a novel regulator for Myc-mediated transcription in embryonic stem cells. PMID: 22328504
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    TRIM/RBCC family
  • 数据库链接：

    KEGG: mmu:94088

    STRING: 10090.ENSMUSP00000095782

    UniGene: Mm.274843