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  4. Recombinant Mouse Tsukushi (Tsku)

Recombinant Mouse Tsukushi (Tsku)

  • 货号：
    CSB-YP025140MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP025140MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP025140MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP025140MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tsku
  • Uniprot No.：
  • 别名：
    Tsku; Lrrc54; Tsk; Tsukushin; Tsukushi; Leucine-rich repeat-containing protein 54
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    18-354
  • 氨基酸序列
    TRP CFPGCQCEEE TFGLFDSFSL IRVDCSSLGP HIVPVPIPLD TAHLDLSSNR LETVNESVLA GPGYTTLAGL DLSYNLLTSI MPSAFSRLRY LESLDLSHNG LAALPAEIFT SSPLSDINLS HNRLREVSIS AFTTHSQGRA LHVDLSHNLI HRLLPHPARA SLPAPTIQSL NLSWNRFRAV PDLRDLPLRY LSLDGNPLAT INPDAFMGLA GLTHLSLASL QGILHLPPHG FRELPGLQVL DLSGNPKLKW AGAEVFSGLG LLQELDLSGS SLVPLPEMLL HHLPALQSVS VGQDVQCRRL VREGAYHRQP GSSPKVVLHC GDTQESAARG PDIL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Contributes to various developmental events and other processes such as wound healing and cholesterol homeostasis through its interactions with multiple signaling pathways. Wnt signaling inhibitor which competes with WNT2B for binding to Wnt receptor FZD4 and represses WNT2B-dependent development of the peripheral eye. Plays a role in regulating the hair cycle by controlling TGFB1 signaling. Required for the development of the anterior commissure in the brain by inhibiting neurite outgrowth. Essential for terminal differentiation of hippocampal neural stem cells. Plays a role in regulating bone elongation and bone mass by modulating growth plate chondrocyte function and overall body size. Required for development of the inner ear through its involvement in stereocilia formation in inner hair cells. Facilitates wound healing by inhibiting secretion of TGFB1 from macrophages which prevents myofibroblast differentiation, maintaining inflammatory cell quiescence. Plays a role in cholesterol homeostasis by reducing circulating high-density lipoprotein cholesterol, lowering cholesterol efflux capacity and decreasing cholesterol-to-bile acid conversion in the liver. In one study, shown to negatively regulate sympathetic innervation in brown fat, leading to reduced energy expenditure. In another study, shown not to affect brown fat thermogenic capacity, body weight gain or glucose homeostasis.
  • 基因功能参考文献：
    1. TSK controls the hair cycle by regulating TGF-beta1 signaling. PMID: 22995554
    2. targeted inactivation of the TSK gene in mice causes expansion of the ciliary body and up-regulation of Wnt2b and Fzd4 expression in the developing peripheral eye PMID: 21856951
    3. a crucial role for TSK for anterior commissure formation in the mouse brain was shown. PMID: 21055390
  • 亚细胞定位：
    Secreted.
  • 组织特异性：
    Expressed in macrophages in inflamed wounds with wound expression starting 2 days post-wounding (dpw) (at protein level). At 7 dpw, expressed from epidermis and extracellular matrix in the wound edge to neoepidermis and granulation tissue and in panniculu
  • 数据库链接：

    KEGG: mmu:244152

    STRING: 10090.ENSMUSP00000091713

    UniGene: Mm.25317