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  4. Recombinant Mouse Tuberoinfundibular peptide of 39 residues (Pth2)

Recombinant Mouse Tuberoinfundibular peptide of 39 residues (Pth2)

  • 中文名称：
    小鼠Pth2重组蛋白
  • 货号：
    CSB-YP856297MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Pth2重组蛋白
  • 货号：
    CSB-EP856297MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Pth2重组蛋白
  • 货号：
    CSB-EP856297MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Pth2重组蛋白
  • 货号：
    CSB-BP856297MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Pth2重组蛋白
  • 货号：
    CSB-MP856297MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Pth2
  • Uniprot No.：
  • 别名：
    Pth2; Tip39; Tipf39; Tuberoinfundibular peptide of 39 residues; TIP39; Parathyroid hormone 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Cytoplasmic domain
  • 表达区域：
    62-100
  • 氨基酸序列
    SLALADDAA FRERARLLAA LERRRWLDSY MQKLLLLDAP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action of PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits.
  • 基因功能参考文献：
    1. TIP39-PTH2R system appears to be a previously unrecognized mechanism for regulation of extracellular matrix formation and wound repair. PMID: 28454729
    2. This study demonstrated that TIP39 signaling plays a role in fear incubation and suggest that may serve to ameliorate the long-term negative outcome of traumatic experience via PTH2R-expressing neurons in the Medial Nucleus of the Amygdala. PMID: 26338326
    3. Data indicate that the nociceptive phenotype of TIP39-knockout {KO) mice was similar to the PTH2R-KO. PMID: 23878240
    4. TIP39/PTH2R signaling inhibits proliferation and alters differentiation of chondrocytes by modulating SOX9 expression PMID: 19706789
    5. Mice with PTH2R-null mutation lacking thermoregulation. PMID: 22159128
    6. Involvement of the TIP39/PTH2-R system in the pathways involved in the successful development of the pups. PMID: 21535248
    7. This study demonistrated that suggested that TIP39 modulates long-term fear recall and that mice lacking TIP39 or its receptor are tools for investigating fear-related psychopathologies. PMID: 21382418
    8. these results suggest that the TIP39/PTH2-R system modulates the effects of novelty exposure on memory performance, potentially by acting on noradrenergic signaling PMID: 20796031
    9. Data indicate that the TIP39 ligand/PTH2 receptor system provides facilitatory regulation of the hypothalamic-pituitary-adrenal axis via hypothalamic glutamatergic neurons and that it may regulate other neuroendocrine systems by a similar mechanism. PMID: 20853513
    10. TIP39 signaling modulates nociception, very likely by inhibiting endocannabinoid circuitry at a supraspinal level PMID: 20696160
    11. PTH1 receptor antagonism PMID: 12084532
    12. We propose that TIP39 is an endogenous ligand of the PTH2R and that they form a neuromodulator system, which is optimally positioned to regulate limbic, endocrine, and auditory brain functions. PMID: 17394159
    13. TIP39 is essential for germ cell development and may act as an autocrine or paracrine agent within the gonads. PMID: 18483145
    14. Current data support the hypothesis that TIP39 modulates anxiety-related behaviors following environmental provocation. PMID: 18700839

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Parathyroid hormone family
  • 组织特异性：
    Expressed in testis and, less abundantly, in liver and kidney. Expressed in seminiferous tubuli and several brain regions, including nucleus ruber, caudal paralemniscal nucleus, nucleus centralis pontis, and nucleus subparafascicularis thalami. Expressed
  • 数据库链接：

    KEGG: mmu:114640

    STRING: 10090.ENSMUSP00000041047

    UniGene: Mm.207078