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  4. Recombinant Mouse Tubulin polyglutamylase TTLL11 (Ttll11)

Recombinant Mouse Tubulin polyglutamylase TTLL11 (Ttll11)

  • 货号：
    CSB-YP025255MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP025255MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP025255MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP025255MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP025255MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ttll11
  • Uniprot No.：
  • 别名：
    Ttll11; Tubulin polyglutamylase TTLL11; EC 6.-.-.-; Tubulin--tyrosine ligase-like protein 11
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-727
  • 氨基酸序列
    MRRSSPEKKP EAEWEADAAA AAAATAAATE SLPAETEKQQ GVDAGAAGDP ERLELEEQPK DVGRIPTPTR RHAPEEGEAR VVRRLPPALP LAQPRPAARA LSQLVKARGR SRSRVYRRSA GSMRPVTVDS SKARTSLDAL KISLRQLRWK EFPFGRRLPC DIYWHGVSFR DSDILSGQVN KFPGMTEMVR KVTLSRALRI MQNLFPEEYN FYPRSWILPE EFQLFVSQVQ TVKEGDPSWK PTFIVKPDSG CQGDGIYLIK DPCDGRLTGT LHNRPAVVQE YIRKPLLIDK LKFDIRLYVL LKSLDPLEIY IAKDGLSRFC TEPYQEPNPQ NLHHVFMHLT NYSLNIHSGK FVHSDSASTG SKRTFSSILC RLSSKGVDIK KVWSDIISLV IKTVIALTPE LKVFYQSDIP TGRPGPTCFQ ILGFDILLMK NLKPMLLEVN ANPSMRIEHE YELSPGVFEN IPSLVDEEVK VAVIRDTLRL MDPLKKKKEI HFPDIYMDRK HRIPPVSDRM SSWKHKGSSL SIVRSQQMEK SFTSKEDLNC DPTGGDSEPN PEAHLPSICL KQVFPKYAKQ FNYLRLVDRM ANLFIRFLGI KGTMKLGPTG FRTFIRNCKL SSSSLSMAAV DILYIDITRR WNSVTVDQRD SGMCLQAFVE AFFFLAQRKF KLQPLHEQVA SLIDLCEYHL SVLDEKRLLC HRGRPLQRNP PQMNRPEHSA TGSSAPRVIG ASKLSQS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Polyglutamylase which modifies tubulin, generating polyglutamate side chains of variable lengths on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin. Preferentially mediates ATP-dependent polyglutamate long side-chain elongation over the initiation step of the polyglutamylation reaction. Preferentially modifies the alpha-tubulin tail over a beta-tail. Required for CCSAP localization to both spindle and cilia microtubules. Promotes tubulin polyglutamylation which stimulates spastin/SPAST-mediated microtubule severing, thereby regulating microtubule functions.
  • 亚细胞定位：
    Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Tubulin--tyrosine ligase family
  • 组织特异性：
    Highly expressed in brain, kidney, liver, lung, muscle and testis. Expressed in heart, spleen and trachea. In the brain, expressed in ependymal cilia, cortex, corpus callosum and striatum.
  • 数据库链接：

    KEGG: mmu:74410

    STRING: 10090.ENSMUSP00000028248

    UniGene: Mm.21591