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  4. Recombinant Mouse Tubulin-specific chaperone E (Tbce)

Recombinant Mouse Tubulin-specific chaperone E (Tbce)

  • 货号：
    CSB-YP807543MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP807543MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP807543MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP807543MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP807543MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tbce
  • Uniprot No.：
  • 别名：
    Tbce; Tubulin-specific chaperone E; Tubulin-folding cofactor E
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-524
  • 氨基酸序列
    SDILPLDVI GRRVEVNGEY ATVRFCGAVP PVAGLWLGVE WDNPERGKHD GSHEGTMYFK CRHPTGGSFV RPSKVNFGDD FLTALKKRYV LEDGPDDDEN SCSLKVGSKQ VQTIGFEHIT KKQSQLRALQ DISLWNCAVS HAGEQGRIAE ACPNIRVVNL SKNLLSTWDE VVLIAEQLKD LEALDLSENK LQFPSDSPTL TRTFSTLKTL VLNKTGITWT EVLHCAPSWP VLEELYLKSN NISISERPVN VLQKMRLLDL SSNPSIDESQ LSLIADLPRL EHLVLSDIGL SSIHFPDAEI GCKTSMFPAL KYLIVNDNQI SEWSFINELD KLQSLQALSC TRNPLSKADK AEEIIIAKIA QLRTLNRCQI LPEERRGAEL DYRKAFGNEW RKAGGHPDPD KNRPNAAFLS AHPRYQLLCC KYGAPEDEEL KTQQPFMLKK QLLTLKIKCS NQPERQILEK QLPDSMTVQK VKGLLSRLLK VPVSELLLSY ESSKMPGREI ELENDLQPLQ FYSVENGDCL LVRW
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Tubulin-folding protein; involved in the second step of the tubulin folding pathway and in the regulation of tubulin heterodimer dissociation. Required for correct organization of microtubule cytoskeleton and mitotic splindle, and maintenance of the neuronal microtubule network.
  • 基因功能参考文献：
    1. This study reported that reduced expression of the tubulin-specific chaperone TBCE leads to defective microtubule polymerization and impaired microtubule-dependent axonal transport in sensory DRG neurons of pmn mice. PMID: 27488538
    2. ARF1/TBCE-mediated cross-talk that coordinates COPI formation and tubulin polymerization at the Golgi. PMID: 24951541
    3. We conclude from our study that the mutation of the TBCE gene affects the auditory nerve and the cochlear hair cells simultaneously, leading to progressive hearing loss PMID: 24120439
    4. Tbce is critical for the maintenance of microtubules in mouse motor axons PMID: 12389029
  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    TBCE family
  • 组织特异性：
    Ubiquitously expressed.
  • 数据库链接：

    KEGG: mmu:70430

    STRING: 10090.ENSMUSP00000047880

    UniGene: Mm.260209