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  4. Recombinant Mouse Tumor necrosis factor receptor superfamily member 8 (Tnfrsf8), partial

Recombinant Mouse Tumor necrosis factor receptor superfamily member 8 (Tnfrsf8), partial

  • 货号：
    CSB-YP723348MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP723348MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP723348MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP723348MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP723348MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Tnfrsf8; Tumor necrosis factor receptor superfamily member 8; CD30L receptor; Lymphocyte activation antigen CD30; CD antigen CD30
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B.
  • 基因功能参考文献：
    1. This study demonstrated the amelioration of MOG35-55 peptide-induced active EAE in CD30 KO mice. CD30 was expressed limitedly on CD4 T cells at the induction phase of experimental autoimmune encephalomyelitis. PMID: 26857493
    2. Data indicate that CD30L/CD30 axis plays a modulatory role in the pathogenesis of experimental autoimmune encephalomyelitis (EAE). PMID: 25533628
    3. role in the maintenance and activation of IL-17A-producing gammadelta T cells PMID: 23549449
    4. These results suggest that CD30 signaling plays an important role in the activation of IL-17A-producing Vgamma1(-) Vgamma4(-) gammadelta T cells bearing Vgamma6 at an early stage of BCG infection. PMID: 23918785
    5. Interference of the CD30-CD30L pathway reduces atherosclerosis development. PMID: 23087358
    6. CD30L/CD30 pathway acts as an accelerator of enteritis in a murine disease model PMID: 22451116
    7. role of CD30L/CD30 interactions in allergic rhinitis; results suggest that CD30L plays an important role in allergic rhinitis PMID: 21739429
    8. Abrogation of CD30 and OX40 signals prevents autoimmune disease in FoxP3-deficient mice. PMID: 21788408
    9. Studies demonstrate that CD30L/CD30 signaling executed by the T-T cell interaction plays a critical role in Th17 cell differentiation. PMID: 20639486
    10. CD30 can signal in a completely TCR-independent fashion to induce IL-13 production by effector T cells. PMID: 12193714
    11. Immunity to CD30 could play a role in Marek disease lymphoma regression. PMID: 15356338
    12. Deficiencies in OX40 and CD30 signals were additive, secondary Ab responses were ablated.OX40/CD30 double-knockout OTII transgenic T cells fail to survive compared with normal T cells when cocultured with CD4(+)CD3(-) cells in vitro. PMID: 15778343
    13. CD30 plays an important role in the generation of long-lived memory CD8+ T cells, at least partly by triggering homing receptors for T(central memory) cells. PMID: 16177108
    14. early CD30 signaling is critical for regulatory T cells-mediated acute graft-versus-host disease protection after major MHC-mismatch bone marrow transplantation PMID: 17068147
    15. These results indicate that CD30 is a regulator of T(h)2 responses in the effector-memory phase and a regulator of IL-13 production in memory cells in the lung. PMID: 18089617
    16. CD30L/CD30 signaling is involved in development of both OXA- and TNBS-induced colitis. Modulation of CD30L/CD30 signaling by mAb could be a novel biologic therapy for inflammatory bowel diseases. PMID: 18242212
    17. CD30 and OX40 signals are both required for the survival but not commitment of CD4 T helper type 1 (Th1) cells. PMID: 18292503
    18. Signaling executed by CD30positive T cell interaction with CD30Lpositive T cells plays a critical role in amplification of T helper type (Th)1 responses that able to produce interferon-gamma against Mycobacterium bovis bacillus Calmette-Guerin infection. PMID: 18941223
    19. ko mice exhibite delayed structuring of pulmonary granulomas and reduced recruitment of lymphocytes after infection with erogenic Mycobacterium avium PMID: 19250702
    20. CD30 signals from lymphoid tissue inducer cells were a primitive mechanism to recruit and prime CD4 T cells PMID: 19342654
    21. Data demonstrate that the crucial role of CD30 signaling in the development of acute asthma may be taken over by other costimulatory molecules like OX40 after long-term exposure to the antigen. PMID: 19544310
    22. Following infection with murine cytomegalovirus, CD30 is necessary for preserving the lymphoid microenvironment by enhancing the protective function of NK cells. PMID: 19731363
    23. signals through CD30 and OX40 are required for the survival of CD4(+) T cells within the small intestine lamina propria. PMID: 19786532

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Detected in thymus and in activated splenocytes.
  • 数据库链接：

    KEGG: mmu:21941

    STRING: 10090.ENSMUSP00000030339

    UniGene: Mm.12810