Recombinant Mouse Type III iodothyronine deiodinase (Dio3), partial

1. Results demonstrate that DIO3 is essential for normal aggression and maternal behaviors, and indicate that abnormal local regulation of thyroid hormone action in the brain may contribute to the social deficits associated with neurodevelopmental disorders. PMID: 28715127
2. Functional analysis revealed that ground-state miRNAs embedded in the Dlk1-Dio3 locus (miR-541-5p, miR-410-3p, and miR-381-3p) promoted pluripotency via inhibition of multi-lineage differentiation and stimulation of self-renewal PMID: 29129685
3. Regulation of the expression and activity of the deiodinases constitutes a cell-autonomous, pre-receptor mechanism that controls crucial steps during the various phases of myogenesis. (Review) PMID: 28630021
4. Cardiac D3 is induced in a mouse model of dilated cardiomyopathy, indicating that D3 induction may be a general response to diverse forms of cardiomyopathy. PMID: 28314380
5. Results indicate that basal cell carcinoma cells constitute an example in which the thyroid hormone signal is finely tuned by the concerted expression of opposite-acting deiodinases. The dual regulation of Dio2 and Dio3 expression plays a critical role in cell cycle progression and cell death by influencing cyclin D1-mediated entry into the G1-S phase. PMID: 28088877
6. A critical role for reduced intracellular TH concentrations in neutrophil function during infection, for which the TH inactivating enzyme D3 appears essential. PMID: 29186449
7. Gene body methylation of noncoding RNA genes was observed and among these microRNA genes were prominent. Of particular note, observed only in hyperphenylalaninemic animals, was hypomethylation of miRNA genes within the imprinted Dlk1-Dio3 locus on chromosome 12. PMID: 26822703
8. Dio3-/- mice display degeneration of retinal cones, the photoreceptors that mediate daylight and color vision. In Dio2-/- mice, cone function was largely normal but deletion of Dio2 in Dio3-/- mice markedly recovered cone numbers and electroretinogram responses, suggesting counterbalancing roles for both enzymes in cone survival. PMID: 28324012
9. The marked phenotypic abnormalities observed in the D3-deficient mouse, including perinatal mortality, growth retardation, and central hypothyroidism in adult animals, require expression of MCT8, confirming the interdependent relationship between the TH transport into cells and the deiodination processes. PMID: 27254003
10. The brain-specific miR-379/miR-410 gene cluster at the imprinted Dlk1-Dio3 domain is implicated in several aspects of brain development and function. PMID: 26744330
11. DNA methylation regulates genomic imprinted DLK1-Dio3 miRNAs in autoimmune lupus PMID: 27070142
12. identify the molecular regulators involved in the recruitment of AFF3 to gDMRs and provide mechanistic insight into the requirement of AFF3 at an enhancer for the expression of an approximately 200-kb polycistronic transcript within the imprinted Dlk1-Dio3 locus PMID: 26728555
13. Gtl2((-/+)) teratomas have decreased expression of 28 miRNAs encoded by the Dlk1-Dio3 domain PMID: 25355544
14. This study provides the spatiotemporal expression and dynamic changes of lncRNAs from Dlk1-Dio3 imprinted region in mouse preimplantation stage embryos and offers insight into the potential mechanisms responsible for Gtl2 activation. PMID: 26005002
15. The existence of unidentified epigenetic determinants of tissue-specific Dio3 imprinting. PMID: 25232934
16. DNA methylation dynamics of a maternally methylated DMR in the mouse Dlk1-Dio3 domain PMID: 25447521
17. Within the supportive environment of a research vivarium, mice lacking all three deiodinases can be bred and survive. PMID: 24949664
18. A novel mutant mouse with hepatocyte-specific D3 deficiency has normal local responses to toxin-induced hepatonecrosis, including normal degrees of tissue necrosis and intact regeneration, but accelerated systemic recovery from non-thyroidal illness. PMID: 25004090
19. Upregulation of Prdm14 results in a highly homogeneous population of authentic pluripotent colonies and prevents the abnormal silencing of the Dlk1-Dio3 locus. PMID: 24552707
20. These results suggest that a cAMP-PKA-mediated pathway participates in Glucagon-like peptide-1 stimulated Dio3 expression in MIN6 cells. PMID: 25241124
21. The crystal structure of the catalytic domain of mouse deiodinase 3 (Dio3) reveals a close structural similarity to atypical 2-Cys peroxiredoxin(s) (Prx). PMID: 25002520
22. Systemic changes in thyroid hormone economy as a result of acute food deprivation are not dependent on the deiodinases D1 or D2 but are mediated in part by sequestration of type 4 and type 3 in tissues and their enhanced metabolism by deiodinase D3. PMID: 24635350
23. Dio3 is preferentially expressed from the maternal allele in pancreatic islets; inactivation of this allele is sufficient to disrupt glucose homeostasis by reducing pancreatic islet area, insulin2 gene expression, and glucose-stimulated insulin secretion PMID: 24885572
24. Data indicate that deiodinase Dio2 was mainly localized in stroma cells before implantation, whereas deiodinase Dio3 was highly expressed in stromal cells after implantation. PMID: 24797630
25. The sonic hedgehog-induced type 3 deiodinase facilitates tumorigenesis of basal cell carcinoma by reducing Gli2 inactivation. PMID: 24693967
26. assays showed that hippocampal gene expression of deiodinases 2 and 3, enzymes involved in thyroid hormone regulation, is increased in resilience to stress-induced depressive syndrome PMID: 24386638
27. Study characterized in detail AK044800, a transcript from the Dlk1-Dio3 imprinted region. PMID: 23515577
28. data identify Dlk1-Dio3 ncRNAs as novel candidate early biomarkers for mouse liver tumor promotion and provide new opportunities for assessing the carcinogenic potential of novel compounds PMID: 23091169
29. Data indicate a set of 29 up-regulated miRNAs originating from the Dlk1-Dio3 genomic imprinted region, which has been identified as a hallmark of pluripotency and proliferation. PMID: 23554452
30. Cerebellar abnormalities in mice lacking type 3 deiodinase and partial reversal of phenotype by deletion of thyroid hormone receptor alpha1. PMID: 23161871
31. Gtl2-Dio3-encoded miRNAs are downregulated in regenerating Mef2a knockout muscle, resulting in upregulated secreted Frizzled-related protein expression and attenuated WNT protein activity. PMID: 23154418
32. Several lines of evidence including Dio3 knockout mice suggest that Dio3 plays crucial roles in heart function/dysfunction, ventricular remodeling, and pathogenesis of restrictive cardiomyopathy. PMID: 22403173
33. Data indicate that, in normal physiological conditions, types 2 and 3 deiodinases (D2 and D3) play critical roles in maintaining local T(3) concentrations within a very narrow range. PMID: 22523155
34. the imprinted delta-like homolog 1/preadipocyte factor (Dlk1/Pref1) and iodothyronine deiodinase type 3 (Dio3) functions converge on the development of brown fat at the transition to independent life. PMID: 22326222
35. these data support the developing recognition that the primary role of thyroid hormone deiodinases in some tissues may be the degradation of thyroid hormone to protect the tissue against thyrotoxicosis. PMID: 21936673
36. D3 expression in perinatal pancreatic beta-cells prevents untimely exposure to thyroid hormone, the absence of which leads to impaired beta-cell function and subsequently insulin secretion and glucose homeostasis PMID: 21828183
37. T3 significantly enhances insulin-induced phosphorylation of Akt, cytoplasm to cell membrane translocations of vesicle-associated membrane protein 2 (VAMP2) and glucose transporter 4 (GLUT4), and glucose uptake in adipocytes. PMID: 21792921
38. conclude that the absence of thyroid hormone receptor alpha results in decreased clearance of thyroid hormone(TH)by type 3 deiodinase and contributes to the TH hypersensitivity PMID: 21292823
39. Pathological ventricular remodeling after myocardial infarction in the mouse leads to high and stable induction of deiodinase iodothyronine type III activity in cardiomyocytes and a local hypothyroid condition. PMID: 21159857
40. activation of the imprinted Dlk1-Dio3 region correlates with pluripotency levels of mouse stem cells PMID: 20382743
41. The results suggest that type 3 deiodinase limits hormonal exposure of the cone to levels that safeguard both cone survival and the patterning of opsins that is required for cone function. PMID: 20203194
42. the Dio3 gene is subject to genomic imprinting and preferentially expressed from the paternal allele in the mouse fetus; also identified a gene that is transcribed antisense from the Dio3 locus PMID: 12399446
43. findings show dramatic age and thyroid state-dependent changes in the expression of iodothyronine deiodinase D1, D2 and D3 in central and peripheral tissues of mice during the first 3 wk of life PMID: 12586753
44. identified a conserved enhancer located 3' of the DIO3 gene containing putative AP-1 and serum response elements, that further increases the serum responsiveness of the Dio3 promoter in a cell-specific manner PMID: 12943987
45. Local inflammation strongly induces type 3 deiodinase activity in inflammatory cells, especially in invading polymorphonuclear granulocytes, suggesting enhanced local degradation of triiodothyronine. PMID: 16150911
46. Results demonstrate that the lack of iodothyronine deiodinase type III function results in neonatal thyrotoxicosis followed later by central hypothyroidism that persists throughout life. PMID: 16410833
47. cross-talk between Sonic hedgehog (Shh)/Gli2 and thyroid hormone in keratinocytes is a pathway by which Shh produces its proliferative effects and offers a potential therapeutic approach to basal cell carcinomas PMID: 17720805
48. Results show that the absence of D3 activity results in impaired clearance of T(3) and significant defects in the mechanisms regulating the thyroid axis at all levels: hypothalamus, pituitary, and thyroid. PMID: 17823249
49. Results suggest that coordinated reciprocal expression of iodothyronine deiodinase types II and III keeps thyroid hormone signaling in bone to very low levels at early stages of bone development. PMID: 18682303
50. Dio3 is important in the modulation of thyroid hormone levels in the regenerating liver, in which decrease in cellular T3 permits an increase in proliferation. PMID: 18787028

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KEGG: mmu:107585

STRING: 10090.ENSMUSP00000133920

UniGene: Mm.154427