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  4. Recombinant Mouse Undifferentiated embryonic cell transcription factor 1 (Utf1)

Recombinant Mouse Undifferentiated embryonic cell transcription factor 1 (Utf1)

  • 货号：
    CSB-YP025760MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP025760MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP025760MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP025760MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP025760MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Utf1
  • Uniprot No.：
  • 别名：
    Utf1; Undifferentiated embryonic cell transcription factor 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-339
  • 氨基酸序列
    MLLRPRRLPA FSPPSPASPD AELRSAGDVP VTTSDAFATS GGMAEPGSPK APVSPDSAQR TPWSARETEL LLGTLLQPAM WRSLLLDRRQ TLPTYRRVSA ALARQQVRRT PAQCRRRYKF LKDKLRDSQG QPSGPFDNQI RQLMGLLGDD GPPRVRRRST GPGRPQRRGR SSLSALAPAP APVEQEAELP LAAENDEPAP ALRFSSSTTK SAGAHRITSS PPLTSTDTLP PEPGHTFESS PTPTPDHDVE TPNEPPGLSQ GRASSPQVAP QSLNTALLQT LTHLGDISTV LGPLRDQLST LNQHVEHLRG SFDQTVSLAV GFILGSAASE RGILGDLRQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a transcriptional coactivator of ATF2.
  • 基因功能参考文献：
    1. LncRNA Gm2044 was identified to inhibit Utf1 mRNA translation and play important roles in spermatogenesis. PMID: 29934815
    2. IPS cells derived from UTF1-selection give rise to functional CMs in vitro. PMID: 25277677
    3. A large region of Utf1 was found to be necessary for direct interaction with N-Myc. PMID: 23665319
    4. Suppression of UTF1 expression in P19 cells by RNA interference enhanced retinoic acid (RA)-induced neuronal differentiation. PMID: 22107969
    5. Data show that UTF1 is a key chromatin component in ES cells, preventing ES cell chromatin decondensation, and aberrant gene expression; both essential for proper initiation of lineage-specific differentiation of ES cells. PMID: 20715181
    6. These results suggest a molecular pathway by which Oct-3/4 induces rapid proliferation and tumorigenic properties of ES cells through activation of the UTF1 gene. PMID: 15923625
    7. UTF1 is a strongly chromatin-associated protein involved in the initiation of ES cell differentiation. PMID: 17785516

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed mainly in pluripotent cells with expression rapidly down-regulated upon cell differentiation.
  • 数据库链接：

    KEGG: mmu:22286

    STRING: 10090.ENSMUSP00000128848

    UniGene: Mm.10205