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  4. Recombinant Mouse Unique cartilage matrix-associated protein (Ucma)

Recombinant Mouse Unique cartilage matrix-associated protein (Ucma)

  • 中文名称：
    小鼠Ucma重组蛋白
  • 货号：
    CSB-YP617946MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Ucma重组蛋白
  • 货号：
    CSB-EP617946MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Ucma重组蛋白
  • 货号：
    CSB-EP617946MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Ucma重组蛋白
  • 货号：
    CSB-BP617946MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Ucma重组蛋白
  • 货号：
    CSB-MP617946MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ucma
  • Uniprot No.：
  • 别名：
    UcmaUnique cartilage matrix-associated protein; Upper zone of growth plate and cartilage matrix associated protein) [Cleaved into: Unique cartilage matrix-associated protein C-terminal fragment; Ucma-C; Gla-rich protein; GRP)]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    65-138
  • 氨基酸序列
    SPKSRDEVNAENRQRLRDDELRREYYEEQRNEFENFVEEQRDEQEERTREAVEQWRQWHYDGLYPSYLYNRQNI
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.
  • 基因功能参考文献：
    1. Data suggest that a novel splice variant of GRP is expressed in cartilage and other tissues (i.e. GRP-F7); GRP-F1 is predominant splice variant expressed in adult tissues. PMID: 24867294
    2. Considering that skeletal development in Ucma-deficient mice is not significantly impaired, protein expression in adult cartilage indicates that Ucma might be involved in skeletal homeostasis and in the mechanical properties of the skeleton PMID: 22155508
    3. Four alternative splicing variants derived from the mouse Ucma/GRP gene in chondrocytes were identified and their expression and subcellular localization during chondrogenesis was determined. PMID: 19819238
    4. The present data strongly suggest an important function of Ucma in the early phase of chondrocyte differentiation. PMID: 17707622
    5. Ucma may be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells PMID: 18156182

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  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.; [Isoform 1]: Secreted. Golgi apparatus.; [Isoform 3]: Secreted. Golgi apparatus.; [Isoform 2]: Cytoplasm, cytoskeleton. Note=Colocalizes with aggresomes, which are aggregates of misfolded proteins, at the centrosome.; [Isoform 4]: Cytoplasm, cytoskeleton. Note=Colocalizes with aggresomes, which are aggregates of misfolded proteins, at the centrosome.
  • 蛋白家族：
    UCMA family
  • 组织特异性：
    Predominantly expressed in resting chondrocytes.
  • 数据库链接：

    KEGG: mmu:68527

    STRING: 10090.ENSMUSP00000110662

    UniGene: Mm.27791