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  4. Recombinant Mouse Uridine phosphorylase 1 (Upp1)

Recombinant Mouse Uridine phosphorylase 1 (Upp1)

  • 中文名称：
    小鼠Upp1重组蛋白
  • 货号：
    CSB-YP025659MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Upp1重组蛋白
  • 货号：
    CSB-EP025659MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Upp1重组蛋白
  • 货号：
    CSB-EP025659MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Upp1重组蛋白
  • 货号：
    CSB-BP025659MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Upp1重组蛋白
  • 货号：
    CSB-MP025659MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Upp1
  • Uniprot No.：
  • 别名：
    Upp1; Up; UppUridine phosphorylase 1; UPase 1; UrdPase 1; EC 2.4.2.3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-311
  • 氨基酸序列
    MAATGTEAKD LENHHNDCFI QLSNPNIAAM KEDVLYHFNL STSTHDFPAM FGDVKFVCVG GSSSRMNTFI KYVAAELGLD HPGKEYPNIC AGTDRYAMYK AGPVLSVSHG MGIPSIGIML HELIKMLYHA RCSNITIIRI GTSGGIGLEP GSVVITQQAV NECFKPEFEQ IVLGKRVIRN TNLDAQLVQE LVQCSSDLNE FPMVVGNTMC TLDFYEGQGR LDGALCSYTE KDKQSYLRAA HAAGVRNIEM ESSVFATMCS ACGLKAAVVC VTLLDRLQGD QINTPHDVLV EYQQRPQRLV GHFIKKSLGR A
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
  • 基因功能参考文献：
    1. Importance of UPase in the activation of fluoropyrimidines, the effect of uridine in protecting normal tissues, and the role for tumor-specific modulation of the phosphorolytic activity in 5-FU or capecitabine-based chemotherapy. PMID: 21954436
    2. Data show that enhanced cytotoxicity of 5-FU by bFGF through modulating the expression of UPP1 at the transcription level. PMID: 19714313
    3. Targeted deletion of both thymidine phosphorylase and uridine phosphorylase and consequent disorders in mice. PMID: 12077348
    4. UPase is a critical enzyme in the regulation of uridine homeostasis and pyrimidine nucleotide metabolism, and 5-fluorouracil activity PMID: 15772079
    5. Taken together, the present study provides the first evidence that uridine protects neurons against ischemic insult-induced neuronal death, possibly through the action of UPase. PMID: 18457515
    6. Thymidine phosphorylase and UPP1 double knockout mice showed increased thymidine and deoxyuridine in tissues and developed encephalopathy. PMID: 19028666

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  • 蛋白家族：
    PNP/UDP phosphorylase family
  • 数据库链接：

    KEGG: mmu:22271

    STRING: 10090.ENSMUSP00000020677

    UniGene: Mm.4610