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  4. Recombinant Mouse Urocortin (Ucn)

Recombinant Mouse Urocortin (Ucn)

  • 中文名称：
    小鼠Ucn重组蛋白
  • 货号：
    CSB-YP025551MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Ucn重组蛋白
  • 货号：
    CSB-EP025551MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Ucn重组蛋白
  • 货号：
    CSB-EP025551MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Ucn重组蛋白
  • 货号：
    CSB-BP025551MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Ucn重组蛋白
  • 货号：
    CSB-MP025551MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ucn
  • Uniprot No.：
  • 别名：
    Ucn; Urocortin
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Cytoplasmic domain
  • 表达区域：
    81-120
  • 氨基酸序列
    DDPPLSIDLT FHLLRTLLEL ARTQSQRERA EQNRIIFDSV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta. Plays a role in the establishment of normal hearing thresholds. Reduces food intake and regulates ghrelin levels in gastric body and plasma.
  • 基因功能参考文献：
    1. Genetic deletion of Ucn1 reduced high levels of intake and preference across 2 weeks of continuous access drinking when alcohol concentrations were increased from 10 to 20 to 40%. Ucn1 deletion did not alter low-level drinking when the alcohol concentration remained at 10%. PMID: 28140406
    2. Taken together, our data indicate that sex shows significant interaction with genotype and Ucn1 during colitis. Human duodenal and colonic biopsies revealed that sex-specific differences exist in levels of CRF receptors and Ucn1 expression in patients with CD compared with the matched non-IBD subjects. To conclude, Ucn1 mediates sex-specific immune and cellular signaling responses via CRF2, emphasizing the need for inclus PMID: 27053649
    3. it is shown that CRH and UCN upregulate galectin-1 expression in Ishikawa cell line and macrophages and this effect is mediated through CRHR1. PMID: 25473847
    4. This study aims to investigate the cellular localization of CRF and UCNs in the ileum and to explore whether and how this cellular expression is altered in conditions of intestinal Schistosoma mansoni-induced inflammation. PMID: 25358399
    5. CNTF activates hypothalamic urocortin 1-expressing neurons both in vitro and in vivo. PMID: 23626705
    6. The absence of the CB1 receptor alters the Ucn1 mRNA and peptide levels in Edinger-Westphal nucleus neurones, concomitant with an augmented stress response and increased anxiety-like behaviour. PMID: 22734681
    7. EWcp-Ucn1 neurons play an important role in EtOH intake, preference, and reward. PMID: 22046429
    8. CRF(1) agonists, Ucn 1 and stressin(1) -A, reduced feeding and induced interoceptive stress, whereas Ucn 2 potently suppressed feeding via a CRF(2) -dependent mechanism without eliciting malaise PMID: 21627635
    9. Ucn1 gene was downregulated in 5-HTT KO and upregulated in 5-HTT TG mice which exhibit opposite changes in anxiety-related behavior; findings suggesti this peptide can be involved in behavioral changes observed in 5-HTT mutant mice PMID: 21075611
    10. This study provides provide evidence for leptin actions that go beyond the hypothalamus and proposes that leptin can directly influence the activity of the midbrain Ucn1 neurons. PMID: 21209012
    11. The lack of brain Ucn 1 immunoreactivity at birth and the gradual postnatal increase in Ucn 1 in the perioculomotor area suggests that this peptide plays a greater behavioral role in adulthood than during the early postnatal development of an organism. PMID: 20064491
    12. Ucn1, CART and nesfatin-1/NUCB2 are specifically involved in the response of Edinger-Westphal nucleus neurons to acute stress in the mouse PMID: 20043894
    13. Urocortin-deficient mice show hearing impairment and increased anxiety-like behavior. PMID: 12091910
    14. Edinger-Westphal nucleus urocortin-expressing neurons mount a response to acute challenge in transgenic mice overexpressing corticotropin-releasing factor. PMID: 14706771
    15. Urocortin induces macrophage apoptosis via Corticotropin-Releasing Factor Receptor-2. PMID: 16054139
    16. Dorsal raphe is a neuroanatomical substrate of urocortin 1-induced reductions in feeding. PMID: 16338088
    17. UCN and AM prevent lethal endotoxemia by decreasing the local and systemic levels of a wide spectrum of inflammatory mediators, including cytokines, chemokines, and the acute phase protein serum amyloid A PMID: 16723707
    18. CRF and urocortin promote the survival of cultured cerebellar GABAergic neurons through the type 1 CRF receptor PMID: 16778399
    19. An important role for UCN1 in the HPA axis adaptation to repeated restraint and in the corticosterone response to a cold environment. PMID: 17456638
    20. UCN located in mouse spermatozoa and exerted inhibitory effects on male reproductive functions including motility and acrosome reaction PMID: 17495470
    21. urocortin modulates T-type Ca(2+) channel by interacting with CRF-R1 via the activation of PKC signal pathway in MN9D cells PMID: 17506983
    22. the Ucn-CRH receptor system may be regulated by two major forms of cardiac stresses, i.e. oxidative and inflammatory stress, and may play a critical role in cardiac stress adaptation in heart diseases PMID: 19318426

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Sauvagine/corticotropin-releasing factor/urotensin I family
  • 组织特异性：
    In the organ of Corti, detected in the inner hair cell region (at protein level). Expressed in skin (at protein level).
  • 数据库链接：

    KEGG: mmu:22226

    STRING: 10090.ENSMUSP00000035321

    UniGene: Mm.377116