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  4. Recombinant Mouse Urocortin-2 (Ucn2)

Recombinant Mouse Urocortin-2 (Ucn2)

  • 货号：
    CSB-YP858154MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP858154MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP858154MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP858154MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP858154MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ucn2
  • Uniprot No.：
  • 别名：
    Ucn2; Urocortin-2; Urocortin II; Ucn II
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    73-110
  • 氨基酸序列
    VILSLDVP IGLLRILLEQ ARYKAARNQA ATNAQILAHV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.
  • 基因功能参考文献：
    1. Urocortin 2 acts on gonadotrophs expressing the corticotropin-releasing factor type 2 receptor, and inhibits the production of gonadotropins in the pituitary gonadotropic tumor cells. PMID: 28851616
    2. Co-administration of neutralizing interleukin-6 receptor antibodies (0.2 mg kg(-1) ) and corticotrophin-releasing factor receptor 2 agonist. PMID: 28665499
    3. results indicate that long-term UVA eye irradiation led to increased gp91phox-derived ROS in the brain and the increased expression of urocortin 2 and CRHR type 2, resulting in photoaging; however, further studies are needed to confirm these findings PMID: 26648475
    4. increased significantly in placenta approaching birth PMID: 25426872
    5. Urocortin 2 autocrine/paracrine and pharmacologic effects to activate AMP-activated protein kinase in the heart. PMID: 24043794
    6. Description of ucn2 posttranslational processing and peptide sequence. Hypoxia and glycosylation, paradigms that might influence secretion or processing of gene products, did not significantly impact hUcn 2 prohormone cleavage. PMID: 23493376
    7. this study demonistrated that male UCN2 null mice showed more passive social interactions. PMID: 22640813
    8. Ucn2 can modulate GnRH mRNA levels PMID: 22138165
    9. CRF(1) agonists, Ucn 1 and stressin(1) -A, reduced feeding and induced interoceptive stress, whereas Ucn 2 potently suppressed feeding via a CRF(2) -dependent mechanism without eliciting malaise PMID: 21627635
    10. findings suggest an important role for UCN2 in cardiovascular homeostasis PMID: 19914944
    11. Ucn II is expressed in the hypothalamus, brainstem, olfactory bulb, and pituitary. Low levels were also detected in the mouse cortex, hippocampus, and spinal cord, Ucn II gene transcription was stimulated by glucocorticoids PMID: 12764078
    12. significant increase in urocortin II mRNA levels in the skin, but not in skeletal muscle, of both corticotropin-releasing factor receptor 1 and 2-null mice PMID: 14736736
    13. Urocortin 2 induces macrophage apoptosis via Corticotropin-Releasing Factor Receptor-2. PMID: 16054139
    14. The differential phenotype of urocortin 2 deficiency in female and male mice may imply a role for urocortin 2 in these gender differences. PMID: 16707802
    15. Ucn 2 inhibited insulin-induced Akt and ERK1/2 phosphorylation in cultured skeletal muscle cells and C2C12 myotubes PMID: 17050686
    16. The selective CRF2 agonist prevented enhanced defecation. PMID: 17194724
    17. the Ucn-CRH receptor system may be regulated by two major forms of cardiac stresses, i.e. oxidative and inflammatory stress, and may play a critical role in cardiac stress adaptation in heart diseases PMID: 19318426
    18. Urocortin 2 inhibits furosemide-induced activation of renin and enhances renal function and diuretic responsiveness in experimental heart failure. PMID: 19919977

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Sauvagine/corticotropin-releasing factor/urotensin I family
  • 数据库链接：

    KEGG: mmu:171530

    STRING: 10090.ENSMUSP00000060405

    UniGene: Mm.388865