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  4. Recombinant Mouse Urotensin-2 (Uts2)

Recombinant Mouse Urotensin-2 (Uts2)

  • 货号：
    CSB-YP886406MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP886406MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP886406MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP886406MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP886406MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Uts2
  • Uniprot No.：
  • 别名：
    Uts2; Ucn2; Urotensin-2; Urotensin II; U-II; UII
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Cytoplasmic domain
  • 表达区域：
    110-123
  • 氨基酸序列
    Q HGAAPECFWK YCI
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Highly potent vasoconstrictor.
  • 基因功能参考文献：
    1. role of urotensin-II and its receptors in sepsis-induced lung injury under diabetic conditions PMID: 29133126
    2. IRF3 expression and activation depend on the signal transduction of the the urotensin II/urotensin receptor (UII/UT) system, and play important roles in UII/UT-mediated immune inflammatory injury in the liver PMID: 27448985
    3. UII/UTR system plays a role in lipopolysaccharide (LPS)/D-galactosamine (GalN)-induced acute liver failure. PMID: 23755157
    4. Data suggest that aortic urotensin II (UII) is increased in diabetes-associated atherosclerosis in humans and mice; diabetes-associated plaque development is attenuated by UII/UII receptor antagonism in in vitro (human) and in vivo (mouse) settings. PMID: 23344731
    5. It is believed that U-II is an important mediator in Systemic sclerosis. PMID: 22886350
    6. role of urotensin II gene deletion in atherosclerosis and suggest that the use of pharmaceutical agents aimed at blocking the urotensin II pathway may provide a novel approach in the treatment of atherosclerosis. PMID: 22723440
    7. 17 amino acid seq and effects on body temperature, water and food consumption, locomotion, exploratory behavior, etc. PMID: 16160878
    8. mouse UII is expressed in a subpopulation of motoneurons in the spinal cord PMID: 16361078
    9. In the CNS UII mRNAs are expressed in brainstem and spinal motoneurons, also expressed in the medial vestibular nucleus, locus coeruleus and the ventral medulla. PMID: 18710417
    10. increased plasma urotensin II level stimulates oxidized low-density lipoprotein and reactive oxygen species production and macrophage foam cell formation PMID: 18806619
    11. Elevated expression of Uts2 in skeletal muscle of diabetic mouse is reported. PMID: 19323985

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Urotensin-2 family
  • 组织特异性：
    Brain specific. Predominantly expressed in motoneurons of the brainstem and spinal cord.
  • 数据库链接：

    KEGG: mmu:24111

    STRING: 10090.ENSMUSP00000030803

    UniGene: Mm.89984