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  4. Recombinant Mouse Vasopressin-neurophysin 2-copeptin (Avp)

Recombinant Mouse Vasopressin-neurophysin 2-copeptin (Avp)

  • 中文名称：
    Recombinant Mouse Vasopressin-neurophysin 2-copeptin(Avp),Yeast
  • 货号：
    CSB-YP002466MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Vasopressin-neurophysin 2-copeptin(Avp),Yeast
  • 货号：
    CSB-EP002466MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Vasopressin-neurophysin 2-copeptin(Avp),Yeast
  • 货号：
    CSB-EP002466MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Vasopressin-neurophysin 2-copeptin(Avp),Yeast
  • 货号：
    CSB-BP002466MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Vasopressin-neurophysin 2-copeptin(Avp),Yeast
  • 货号：
    CSB-MP002466MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    AvpVasopressin-neurophysin 2-copeptin; AVP-NPII) [Cleaved into: Arg-vasopressin; Arginine-vasopressin); Neurophysin 2; Neurophysin-I); Copeptin]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    36-128
  • 氨基酸序列
    AISDM ELRQCLPCGP GGKGRCFGPS ICCADELGCF VGTAEALRCQ EENYLPSPCQ SGQKPCGSGG RCAAVGICCS DESCVAEPEC HDGFFRLT
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Neurophysin 2 specifically binds vasopressin.; Vasopressin has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels. Acts by binding to vasopressin receptors (V1bR/AVPR1B, V1aR/AVPR1A, and V2R/AVPR2).
  • 基因功能参考文献：
    1. The abnormal social behaviors of Dio3-/- mice were associated with sexually dimorphic alterations in the physiology of oxytocin (OXT) and arginine vasopressin (AVP), 2 neuropeptides with important roles in determining social interactions. PMID: 28715127
    2. Data suggested that arginine vasopressin in the brain, not spinal cord and peripheral system of spinocerebellar ataxia type 3 mice related with the change of the spatial learning and memory of Morris water maze test. PMID: 28619276
    3. The suprachiasmatic nucleus (SCN)network consists of multiple clusters of cellular circadian rhythms that are differentially integrated by AVP and VIP signaling, depending on the postnatal period PMID: 27626074
    4. These results identify G9a-induced histone methylation at the OXT and AVP promoters in the Basolateral Amygdala as a mechanism for mediating stress-induced lasting behavioral depression and its reversal by exercise. PMID: 25863961
    5. PDZ domain-containing protein Sipa1l1 (signal-induced proliferation-associated 1 like 1) binds to the cytoplasmic PDZ-ligand motif of aquaporin-2 and accelerates its endocytosis in the absence of vasopressin PMID: 28336531
    6. Spatiotemporal profiles of arginine vasopressin (AVP) expression at the pixel level revealed circadian rhythms in the entire area of AVP-positive cells in the suprachiasmatic nucleus, and at least two clusters that showed different circadian oscillations. PMID: 26342201
    7. Results suggest morphological and functional differences among the paraventricular nucleus' subnuclei and complex interactions among Chronic Unpredictable Stress, gonadal hormones and AVP immunoreactivity PMID: 25218558
    8. Autophagy was induced in the AVP neurons subjected to endoplasmic reticulum stress in familial neurohypophysial diabetes insipidus mice. PMID: 24675466
    9. A new role of PcG proteins in priming early-life stress-responsive DNA methylation at the Avp enhancer prior to epigenetic programming. PMID: 24599304
    10. The noradrenaline-nitric oxide pathway, which stimulates the expression of vasopressin, involves free radicals. PMID: 24681257
    11. AVP, via activation of V1 receptors, is able to modulate positively contractile activity of longitudinal muscle of mouse distal colon. PMID: 24185041
    12. Dehydration increased plasma osmolality and vasopressin levels, and suppressed the increase in blood flow induced by neural activity, by the endothelium-dependent vasodilator acetylcholine and the smooth muscle relaxant adenosine. PMID: 24517977
    13. Vasopressin expression in the suprachiasmatic nucleus is independent of Crx (cone-rod homeobox)-regulated photoreceptor systems. PMID: 23784879
    14. This suggests that increased IL-1beta and NO levels may cause significant bioenergetics changes in magnocellular neurons, affecting copeptin expression and compromising AVP synthesis and secretion in the late phase of sepsis. PMID: 24360909
    15. Folate deficiency decreases the circadian amplitude of vasopressin and the clock protein PER2. PMID: 23273571
    16. medial amygdala likely modulates hostile aggressive behavior associated with immediate early gene expression in oxytocin and vasopressin neurons PMID: 23403283
    17. results support the idea that variation in ovarian hormones could be related to individual differences in social recognition, at least partly through modulation of the OT and/or AVP systems, particularly in the DS, LA and MPOA. PMID: 22079582
    18. The data suggested that vasopressin or oxytocin exert a minimal effect on most GABA neurons in the lateral hypothalamus but exert a robust excitatory effect on presumptive GABA cells that contain melanin-concentrating hormone. PMID: 22262306
    19. Results indicate that Inpp5k 5-phosphatase is important for the control of the arginine vasopressin/aquaporin-2 signalling pathway and water transport in kidney collecting ducts. PMID: 21938401
    20. Hypothalamic COX-2 activity was not necessary for enhanced arginine vasopressin expression and secretion in response to water deprivation. PMID: 21880835
    21. Results suggest that, compared with other species, the mouse has a particularly robust and widespread distribution of AVP-ir fibers, which, as in other species, originates from a number of different cell groups in the telencephalon and diencephalon. PMID: 21456024
    22. We suggest that AVP secretion is critically regulated by tPA-dependent facilitation of AVP release from terminals and plasminogen-dependent increase of AVP permeability across microvessels possibly via laminin degradation. PMID: 20175210
    23. Results suggest that estrogen receptor-beta activation may play a critical role in estrogenic regulation of oxytocin and arginine vasopressin gene expression in the paraventricular nucleus. PMID: 12531518
    24. AVP specifically inhibits expression of the cyclin D1 gene in Y1 adrenocortical tumor cells, leading to cell cycle blockage and halting cell proliferation. PMID: 12590600
    25. Regulatory element in the intergenic region of the Vp gene controls hypothalamus-specific expression. PMID: 12944509
    26. Results suggest ways in which oxytocin may play a cooperative role together with arginine vasopressin in the regulation of sodium balance. PMID: 14962074
    27. The mechanism behind AVP escape in liver cirrhosis seems to involve decreased collecting duct sensitivity to AVP as a result of increased cAMP-phosphodiesterase activity. PMID: 15172884
    28. Reduced hypothalamic vasopressin signaling plays a role in the absence of the proestrous LH surge in Clock mutant mice. PMID: 16870944
    29. provides new evidence for the essential role of the AVP system in embryonic stem cell-derived cardiomyogenesis PMID: 17298949
    30. Changes in plasma and brain vasopressin levels in IRAP(-/-) mice suggest a significant role for IRAP in regulating vasopressin. PMID: 17684103
    31. Neuronal nitric oxide synthase gene inactivation reduces the expression of vasopressin in the hypothalamic paraventricular nucleus and of catecholamine biosynthetic enzymes in the adrenal gland of the mouse. PMID: 17853069
    32. These data indicate that AVP regulates body fluid homeostasis and GFR via the V1aR in macula densa cells by activating RAS and subsequently the V2R-AQP2 system. PMID: 18448596
    33. Even though Bcl-2 overexpression increased VP cell number, it did not affect fiber density. PMID: 18499746
    34. Data demonstrate need for autophagy-mediated degradation of toxic, mutated arginine vasopressin C98X peptides, and suggest that, in the presence of mis-folded proteins, the stimulation of Akt signalling counteracts autophagy and precipitates cell death. PMID: 18673414
    35. Results suggest that exposure to chronic subordinate colony housing enhances anxiety, an effect that seems to be independent of the hypothalamic expression of the neuropeptides oxytocin and arginine vasopressin. PMID: 19120108
    36. Cell death is not the primary cause of polyuria in familial neurohypophysial diabetes insipidus. Aggregates accumulated in the ER might be involved in the dysfunction of arginine vasopressin neurons that lead to the progressive polyuria. PMID: 19297548
    37. Data show that arginine vasopressin mRNA levels in the paraventricular nucleus were found to correlate with anxiety-related and depression-like behaviors in mice. PMID: 19357765
    38. AT(1a) receptor deletion causes polyuria and urine concentration defects by decreasing basal AVP release and impairing AVP-induced receptor signaling in the inner medu PMID: 19387470

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Vasopressin/oxytocin family
  • 数据库链接：

    KEGG: mmu:11998

    STRING: 10090.ENSMUSP00000035551

    UniGene: Mm.6190