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  4. Recombinant Mouse Vesicular glutamate transporter 3 (Slc17a8), partial

Recombinant Mouse Vesicular glutamate transporter 3 (Slc17a8), partial

  • 货号：
    CSB-YP804773MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP804773MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP804773MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP804773MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP804773MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Slc17a8; Vglut3; Vesicular glutamate transporter 3; VGluT3; Solute carrier family 17 member 8
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.
  • 基因功能参考文献：
    1. VGluT3 KO mice show innate fear without significant influence on fear memory and generalization. PMID: 29310485
    2. VGluT3-expressing amacrine cells provide selective glycinergic input to a retinal ganglion cell type suppressed by contrast and motion PMID: 27160915
    3. Results reveal that VGLUT3 plays an important role in the development of l-DOPA-induced dyskinesia (LID), and should be considered as a potential and promising therapeutic target for prevention of LID PMID: 26711621
    4. Synaptic excitation of W3 ganglion cells is diminished, and responses to object motion are suppressed in mice lacking VGluT3. PMID: 25988808
    5. Measurements of time spent in noisy versus attenuated environments reveal noise-avoidance behavior in mice expressing VGLUT3 whereas Vglut3-/- mice showed no preference. PMID: 25639244
    6. Transient expression of VGLUT3 by a discrete population of neurons in the dorsal horn is required for mechanical pain. PMID: 26291162
    7. Results showed that VGLUT3 expression has little or no effect on vesicular synergy at the immature glycinergic synapse of brainstem PMID: 25505386
    8. The possible contribution of VGLUT3 upregulation in the cochlear degeneration is discussed. PMID: 25450145
    9. Our data demonstrate that VGLUT3 is required for normal cholinergic signaling onto striatal fast-spiking interneurons, as well as for acetylcholine-dependent disynaptic inhibition of medium spiny neurons. PMID: 24966377
    10. This study demonistrated that vglut3 are present in synaptic vesicles in acetylcholinergic nerve terminals in the striatum. PMID: 23633129
    11. VGLUT3 contributes to protection against neonatal hypoxic stress PMID: 22890712
    12. The physiological properties and anatomical features of the VGLUT3+ amacrine cells suggest that this bistratified interneuron may play a role in disinhibitory signaling. PMID: 21864449
    13. These data imply a glutamate cycle in which glutamate is carried into the granules by VGLUT3 and carried out by EAAT2. PMID: 21853059
    14. Our data demonstrate that, in nearly mature mice, the slow component of DSE occurs through vesicular release of Glu that involves VGLUT3. PMID: 21177991
    15. Vesicular glutamate transporter 3 has a role in age-dependent optic neuropathy PMID: 21311743
    16. VGLUT3 accelerates 5-HT transmission at the level of specific 5-HT terminals and can exert an inhibitory control at the raphe level. PMID: 20147547
    17. genetic deletion of Vglut3 disrupted glutamate co-transmission and severely impaired auditory pathway refinement; findings reveal a role for VGLUT3 and glutamate co-transmission in the developmental organization of an inhibitory pathway PMID: 20081852
    18. cloning and functionally characterization; expressed on synaptic vesicles that identifies a distinct glutamatergic system in the brain that is partly and selectively promiscuous with cholinergic and serotoninergic transmission (VGLUT3) PMID: 12384506
    19. Sensorineural deafness and seizures in mice lacking vesicular glutamate transporter 3. PMID: 18215623
    20. Loss of Vglut3 caused a hypocholinergic striatal phenotype. In Vglut3(-/-) mice, acetylcholine release was decreased in striatum slices lacking VGLUT3. PMID: 18278042
    21. SLC17A8 encodes vesicular glutamate transporter-3, VGLUT3 and its impairment has a role in nonsyndromic deafness DFNA25 and inner hair cell dysfunction PMID: 18674745
    22. The loss of VGLUT3 specifically impairs mechanical pain sensation, and in particular the mechanical hypersensitivity to normally innocuous stimuli that accompanies inflammation, nerve injury and trauma PMID: 19915548

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  • 亚细胞定位：
    Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome.
  • 蛋白家族：
    Major facilitator superfamily, Sodium/anion cotransporter family, VGLUT subfamily
  • 组织特异性：
    Expressed in restricted areas of the brain. Highest expression is found in the neurons of the basal forebrain, the hippocampal formation, and the majority of the neurons of the mesencephalic raphe nuclei. Expressed in inner hair cells of the ear.
  • 数据库链接：

    KEGG: mmu:216227

    STRING: 10090.ENSMUSP00000020102

    UniGene: Mm.233921