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  4. Recombinant Mouse Visual system homeobox 1 (Vsx1)

Recombinant Mouse Visual system homeobox 1 (Vsx1)

  • 货号：
    CSB-YP025938MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP025938MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP025938MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP025938MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP025938MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Vsx1
  • Uniprot No.：
  • 别名：
    Vsx1; RinxVisual system homeobox 1; Homeodomain protein RINX; Retinal inner nuclear layer homeobox protein; Transcription factor VSX1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-363
  • 氨基酸序列
    MTGRDGLSDA RSRSRALAPG CPPTGSRLRS FAINDLLGLE ADLPTPAEPG LRSNSGDPAE AIGSGPGPGP GLCGSCPARG ALPLGLGLLC GFGAQPPSAA AAARARCLLL ADLRLLPSAG PEPAVAQGPV HPPPALGSQQ RSESVSTSDG DSPSEEKNDP KMSLILGKRK KRRHRTVFTA HQLEELEKAF GEAHYPDVYA REMLAAKTEL PEDRIQVWFQ NRRAKWRKRE KRWGGSSVMA EYGLYGAMVR HCIPLPDSVL NSADSLQGSC APWLLGMHKK STGMRKPESE DKLAGLWEFD HLKKGANKDE DGPERGPDET TQNPENSLED VAIDLSSSSR QETKKMPPGS STQLPQPPQV GAS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds to the 37-bp core of the locus control region (LCR) of the red/green visual pigment gene cluster. May regulate the activity of the LCR and the cone opsin genes at earlier stages of development. Dispensable in early retinal development.
  • 基因功能参考文献：
    1. These findings reveal a role for Vsx1 in type 3a bipolar cells and suggest that Vsx1 function is required transiently in this cell type during the postnatal period. PMID: 21674500
    2. findings indicate that Vsx1 regulates terminal gene expression in Type 7 bipolar cells and is necessary for proper ON visual signaling within a directionally selective circuit. PMID: 21917795
    3. role in late differentiation and function of OFF-CB cells and is associated with a heritable OFF visual pathway-specific retinal defect PMID: 14745032
    4. Vsx1 is required for cone bipolar cell differentiation and regulates photopic vision perception. PMID: 15043821
    5. Although Vsx1 mRNA is upregulated in Chx10/Vsx2 deficient RPCs, Vsx1 does not genetically compensate for loss of Chx10/Vsx2, demonstrating that Prd-L:CVC genes, although important, are not absolutely required to initiate retinal development. PMID: 17919464
    6. Transcription factor visual system homeobox 1 homolog (Vsx1) controls specific aspects of visual function in the neural circuitry of the mammalian retina. PMID: 18322081

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Paired homeobox family
  • 组织特异性：
    Expressed in the postnatal retina (at protein level). In the adult, expressed exclusively in the cells of the neural retina with expression restricted to postnatal cone bipolar interneurons.
  • 数据库链接：

    KEGG: mmu:114889

    STRING: 10090.ENSMUSP00000039088

    UniGene: Mm.207061